Comparison of Extra Vascular Lung Water Index in Covid-19 ARDS and "Typical"ARDS Patients
Study Details
Study Description
Brief Summary
Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from "typical" Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation. Thus, pathophysiology of Covid-19 ARDS is different, which requires different interventions than typical ARDS. The investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ARDS with transpulmonary thermodilution (TPTD) technique. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) will be compared.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Typical ARDS ARDS due to non Covid19 causes |
Device: Extravascular Lung Water Index
Measurement of the EVLWI
Device: Pulmonary Vascular Permeability Index
Measurement of the PVPI
|
C-ARDS ARDS due to Covid19 |
Device: Extravascular Lung Water Index
Measurement of the EVLWI
Device: Pulmonary Vascular Permeability Index
Measurement of the PVPI
|
Outcome Measures
Primary Outcome Measures
- Extravascular Lung Water Index [1 day]
The amount of fluid accumulated in the lung measured by transpulmonary thermodilution (ml/kg)
- Pulmonary vascular permeability index [1 day]
Integrity of the alveolocapillary barrier measured by transpulmonary thermodilution
Eligibility Criteria
Criteria
Inclusion Criteria:
-
ARDS defined by Berlin Criteria longer than 24 hours
-
Undergoing mechanical ventilation
-
Noradrenaline demand >0.1 mcg/kg/min
Exclusion Criteria:
-
Not meeting ARDS criteria
-
Noninvasive mechanical ventilation
-
ARDS resolved shorter than 24 hours
-
Shock resolved
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Istanbul University-Cerrahpaşa | Istanbul | Turkey |
Sponsors and Collaborators
- Istanbul University-Cerrahpasa
Investigators
- Study Director: Yalım Dikmen, Prof, Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 0308202247