Comparison of Myocardial Infarction Patients Who Were Prescribed a Novel Antiplatelet Agent or Clopidogrel
Study Details
Study Description
Brief Summary
Myocardial infarction is defined according to icd-10 using the data base of South korea National Health Insurance Corporation, where personal identification information has already been removed, and detailed results are derived for each drug category.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
The purpose of this study is to compare the prognosis of patients with clopidogrel after early discontinuation of ticagrelor/prasugrel with patients who maintained aspirin and ticagrelor/prasugrel as standard therapy in patients with acute myocardial infarction who underwent percutaneous coronary intervention.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| ticagrelor/prasugrel Group Patients with acute myocardial infarction who underwent percutaneous coronary intervention and maintained aspirin and ticagrelor/prasugrel as standard therapy. |
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| clopidogrel Group In patients with acute myocardial infarction who underwent percutaneous coronary intervention, discontinued ticagrelor/prasugrel and switched to clopidogrel |
Outcome Measures
Primary Outcome Measures
- Composite of all-cause death, recurrent myocardial infarction, stroke, (ischemic and hemorrhagic ) and bleeding within one year. [Percutaneous coronary intervention after 1 Year]
compared patients who maintained ticagrelor/Prasugrel with those who switched from ticagrelor/prasugrel to clopidogrel. All cause death Myocardial infarction Stroke Bleeding Categorical data is indicated by number (%) and analyzed by X2 statistics. Continuous variables are expressed as mean standard deviation (±SD) , and in the case of skewed distribution, comparison is made by Mann-Whitney test or Student t test. To balance differences in baseline characteristics, stabilized inverse probability of treatment weighting (sIPTW) is used. For further analysis, consider propensity score matching (PSM) with nearest neighbor method and standardized mortality ratio weighting (SMRW) estimation. Propensity score uses a generalized additive logistic model and considers demographic data (age, gender, hypertension, diabetes mellitus, heart failure hemodialysis).
Eligibility Criteria
Criteria
Inclusion Criteria:
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Patients who have a diagnosis code for acute myocardial infarction indicated in the National Health Insurance data and data for drugs that have used ticagrelor/prasugrel for 30-90 days when hospitalized for the relevant disease.
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Patients who switched to clopidogrel after 30-90 days.
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Patients with a diagnosis code for Venus myocardial infarction and a prescription code for percutaneous cardiovascular intervention in the National Health Insurance data.
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Adults 18 years of age or older
Exclusion Criteria:
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A person who has data for requesting blood transfusion during the period of hospitalization in the National Health Insurance data
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Those who have data for oral anticoagulants (warfarin, Coumadin, apixaban, edoxaban, dabigatran, rivaroxaban) in the National Health Insurance data
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Those who have a diagnosis code for malignant tumor in the National Health Insurance data
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Those who have end-stage renal failure code in the National Health Insurance data or those who have data for hemo/peritoneal dialysis
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A person who has a request for blood transfusion during the period of using Ticagrelor/prasugrel
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | The Catholic University of Korea, Uijeongbu ST. Mary's Hospital | Uijeongbu | Korea, Republic of | 11765 |
Sponsors and Collaborators
- Chan Joon Kim
- Chong Kun Dang Pharmaceutical
Investigators
- Principal Investigator: Chan Joon Kim, The Catholic University of Korea, Uijeongbu ST. Mary's Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CKD-HIRA-Data-Review