Comparison of Scalp Microbiota of the Psoriasis and Seborrheic Dermatitis Patients

Sponsor

Istanbul Medeniyet University (Other)

Overall Status

Completed

CT.gov ID

NCT03807453

Collaborator

Turkish Dermatology Association (Other)

Enrollment

Location

1.8

Actual Duration (Months)

16.9

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

A sterile swap specimen taken from the scalp of the patients with psoriasis vulgaris or seborrheic dermatitis and the volunteer control group will be examined in our study. The examples of the microbiota of the patients will be taken both the lesional scalp and the lesion-free part of the scalp. Then, the microbiota differences between the lesioned scalp and the lesion-free scalp of both groups, and the microbiome differences between the two groups and the control group will be evaluated.

Condition or Disease	Intervention/Treatment	Phase
Psoriasis Vulgaris Seborrheic Dermatitis Microbial Colonization	Other: Microbiota

Study Design

Study Type:

Observational

Actual Enrollment :

30 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Official Title:

Comparison of Scalp Microbiota of the Patients With Psoriasis Vulgaris and Seborrheic Dermatitis

Actual Study Start Date :

Apr 25, 2019

Actual Primary Completion Date :

Jun 18, 2019

Actual Study Completion Date :

Jun 18, 2019

Arms and Interventions

Arm	Intervention/Treatment
Psoriasis Vulgaris patients-Lesion	Other: Microbiota The scalp microbiota
Psoriasis Vulgaris patients-Lesion free	Other: Microbiota The scalp microbiota
Seborrheic Dermatitis-Lesion	Other: Microbiota The scalp microbiota
Seborrheic Dermatitis-Lesion free	Other: Microbiota The scalp microbiota
Control Group	Other: Microbiota The scalp microbiota

Outcome Measures

Primary Outcome Measures

The scalp microbiota of the patients with psoriasis and seborrheic dermatitis [6 months]
The aim of this study is to compare the scalp microbiota of psoriasis vulgaris and seborrheic dermatitis both the lesion and lesion-free parts and also the control group and to assess their role on etiopathogenesis. Determining the microbiota of this region which is frequently involved and resistant to treatment may change the treatment approach. In addition, scalp microbiome of seborrheic dermatitis may be a causal factor of rapid relapse after treatment. The similarities between the microbiota of the psoriasis vulgaris and seborrheic dermatitis cases with only scalp involvement can guide us not only for the diagnosis but also the treatment. There are a few reports about the role of Malassezia subgroups in the pathogenesis, but it is known that there are many different flora members on the scalp. Exposing these can change both our diagnosis and treatment options.

Secondary Outcome Measures

The differences between the scalp microbiota of different countries [6 months]
Does the microbiota of the patients change between the countries? To our knowledge, there is no similar studies in present. Presenting the scalp microbiome of Turkish population can be a start to understand whether there is a difference in terms of the countries.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 80 Years

Sexes Eligible for Study:

All

Inclusion Criteria:

Patients with scalp psoriasis
Patients with seborrheic dermatitis
Agree to participate in research 4 - Do not use any drugs for their disease topically or systemically for two months

Exclusion Criteria:

Patients who do not want to participate in the study
Patients with psoriasis vulgaris or seborrheic dermatitis that does not effect scalp.
Those with chronic diseases that may affect skin microbiome
Patients using antibiotics, antifungal or antiviral therapy for any reason for the last one month.
Patients who are using topical or systemic drugs for their illness