Computerized Neuropsychology in Idiopathic Normal Pressure Hydrocephalus (INPH)

Sponsor

Umeå University (Other)

Overall Status

Completed

CT.gov ID

NCT01265251

Collaborator

(none)

Enrollment

Location

Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

A computerised neuropsychological test battery to be used as a standardised tool assessing the cognitive domains affected by idiopathic normal pressure hydrocephalus INPH was developed. The aim of this study is to investigate the reliability, validity and feasibility of the battery.

Condition or Disease	Intervention/Treatment	Phase
Normal Pressure Hydrocephalus	Device: Computerized neuropsychological test Other: Conventional neuropsychological test

Study Design

Study Type:

Observational

Actual Enrollment :

97 participants

Time Perspective:

Cross-Sectional

Official Title:

Evaluation of a Computerised Neuropsychological Test Battery for Idiopathic Normal Pressure Hydrocephalus (INPH)

Study Start Date :

Aug 1, 2007

Actual Primary Completion Date :

Apr 1, 2010

Actual Study Completion Date :

Apr 1, 2010

Arms and Interventions

Arm	Intervention/Treatment
Test-retest Forty-four healthy elderly 60-82 years old	Device: Computerized neuropsychological test Computerized neuropsychological test battery.
Validity Twenty six patients with various diseases and various ages	Device: Computerized neuropsychological test Computerized neuropsychological test battery. Other: Conventional neuropsychological test Conventional neuropsychological test (paper and pen)
Feasibility Twenty seven patients under the preoperative investigation for INPH	Device: Computerized neuropsychological test Computerized neuropsychological test battery.

Arm

Intervention/Treatment

Test-retest

Forty-four healthy elderly 60-82 years old

Device: Computerized neuropsychological test

Computerized neuropsychological test battery.

Validity

Twenty six patients with various diseases and various ages

Device: Computerized neuropsychological test

Computerized neuropsychological test battery.

Other: Conventional neuropsychological test

Conventional neuropsychological test (paper and pen)

Feasibility

Twenty seven patients under the preoperative investigation for INPH

Device: Computerized neuropsychological test

Computerized neuropsychological test battery.

Outcome Measures

Primary Outcome Measures

Validity [Within 24 h]
Computerized test battery and equivalent standard neuropsychological test battery is given to the same subject. Correlation between paper and pen and equivalent computerized test is calculated as a validity measure.
Reliability [More than 7 days, within 2 months]
The computerized test battery is given to the same subject twice. Correlation between the two tests is calculated as a test-retest reliability measure.
Feasibility [Within 24 h]
Patients under the investigation for INPH are given the computerized test battery. Number of patients who manage to complete the test is the feasibility measure.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Probable INPH under investigation
Healthy elderly
Various diseases

Exclusion Criteria:

(Healthy elderly) medications affecting nervous system
(Healthy elderly)heart disease
(Healthy elderly)diabetes
(Healthy elderly)disease of the nervous system
(Healthy elderly)MMSE < 28
(Healthy elderly)vascular risk factors (Two of: 1 hypertension, 2 smoking or 3 hyperlipidemia)
(Healthy elderly)serious disease that may shorten life expectancy
(Various diseases) Affected motor functions