Confusion in the Elderly After Colon Surgery
Study Details
Study Description
Brief Summary
A study will be conducted to determine if there is any cognitive benefit in elderly patients having open versus minimally invasive colon cancer surgery.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Detailed Description
Cognitive changes in the elderly are common after surgery. It is not known if minimally invasive or laparoscopic surgery can prevent these changes. A study will be conducted on patients scheduled to have abdominal surgery. The patients will have cognitive evaluations before and after surgery. A small amount of blood, about 2 tablespoons, will be collected no more than 5 times in 6 months. The results will be analyzed to determine if there are changes between those having open surgery versus patients having laparoscopic or minimally invasive surgery, and if these changes coincide with cognitive changes.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Laparoscopic colon surgery Patients over age 65 having laparoscopic colon resection for colonic adenocarcinoma |
|
| Open colon surgery Patients over age 65 having open colon resection for colonic adenocarcinoma |
Outcome Measures
Primary Outcome Measures
- Confusion [6 Months]
Confusion assessed by questionaires and cognitive testing
Secondary Outcome Measures
- degree of inflammation [6 Months]
5 separate blood draws
- presence of electrolyte imbalance [6 months]
5 separate blood draws
- pituitary-thyroid axis disruption [6 months]
5 separate blood draws
- liver function tests [6 months]
5 separate blood draws
- nutritional status [6 months]
5 separate blood draws
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patients over age 65.0 years and in need of elective colon resection for adenocarcinoma
Exclusion Criteria:
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Inability to complete preoperative cognitive screening
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Inability to complete study in English since CANTAB is timed and not validated with interpreters
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Emergency surgery
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Depression or psychiatric comorbidity
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Pre-existing dementia
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Previous cerebrovascular accident or "stroke"
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Previous myocardial infarction
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Cardiac ejection fraction below 55%
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Propranolol, metoprolol or other betablocker use
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Digoxin, procainamide, or amiodarone use
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Calcium channel blocker use
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History of vascular surgery or arterial vascular disease
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History of alcohol dependence
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Lovastatin or other HMG-CoA reductase inhibitor use
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Ace inhibitor use
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Neuroendocrine or catecholamine associated tumors
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Hypertension
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Diabetes
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Benzodiazepine use
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Dimenhydrinate or other medications to treat motion sickness
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Metaclopramide use
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | New York Hospital Queens | Flushing | New York | United States | 11355 |
Sponsors and Collaborators
- New York Hospital Queens
- New York State Department of Health
Investigators
- Principal Investigator: Mitchell I Chorost, MD, New York Hospital Queens
Study Documents (Full-Text)
None provided.More Information
Publications
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