Prospective Randomized Comparison of Zymar(Gatifloxacin) and Vigamox (Moxifloxacin) in Killing Conjunctival Bacterial Flora Following a One-hour Application
Sponsor
Stanford University (Other)
Overall Status
Withdrawn
CT.gov ID
NCT00466570
Collaborator
(none)
0
Study Details
Study Description
Brief Summary
Topical ophthalmic antibiotics are common prescribed just prior to eye surgery to lower the risk of infection. Previous studies have suggested that antibiotics containing a preservative (Zymar) kill bacteria much quicker than those without a preservative (Vigamox). The purpose of this research is to compare how quickly to the two commonly prescribed antibiotics eliminate bacteria from the eye surface.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Study Type:
Interventional
Actual Enrollment
:
0 participants
Allocation:
Randomized
Intervention Model:
Factorial Assignment
Masking:
Single
Primary Purpose:
Prevention
Official Title:
Prospective Randomized Comparison of Zymar(Gatifloxacin) and Vigamox (Moxifloxacin) in Killing Conjunctival Bacterial Flora Following a One-hour
Study Start Date
:
Apr 1, 2007
Outcome Measures
Primary Outcome Measures
- Antibiotic killing of conjunctival bacterial flora 1 hour after application []
Eligibility Criteria
Criteria
Ages Eligible for Study:
50 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Age- older than 50 years of age
-
Diagnosis- Cataract or had cataract surgery
Exclusion Criteria:
-
Systemic or topical antibiotic treatment within 30 days
-
Use of systemic or topical steroids
-
Active ocular infection
-
Ocular surgery in the past 6 months
-
Allergy to fluoroquinolones
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Stanford University
Investigators
- Principal Investigator: Christopher Ta, MD, Stanford University
Study Documents (Full-Text)
None provided.More Information
Publications
- de Kaspar HM, Kreidl KO, Singh K, Ta CN. Comparison of preoperative conjunctival bacterial flora in patients undergoing glaucoma or cataract surgery. J Glaucoma. 2004 Dec;13(6):507-9.
- Miño de Kaspar H, Koss MJ, He L, Blumenkranz MS, Ta CN. Antibiotic susceptibility of preoperative normal conjunctival bacteria. Am J Ophthalmol. 2005 Apr;139(4):730-3.
- Ta CN, Chang RT, Singh K, Egbert PR, Shriver EM, Blumenkranz MS, Miño de Kaspar H. Antibiotic resistance patterns of ocular bacterial flora: a prospective study of patients undergoing anterior segment surgery. Ophthalmology. 2003 Oct;110(10):1946-51.
- Ta CN, Egbert PR, Singh K, Shriver EM, Blumenkranz MS, Miño De Kaspar H. Prospective randomized comparison of 3-day versus 1-hour preoperative ofloxacin prophylaxis for cataract surgery. Ophthalmology. 2002 Nov;109(11):2036-40; discussion 2040-1.
- Ta CN, He L, Nguyen E, De Kaspar HM. Prospective randomized study determining whether a 3-day application of ofloxacin results in the selection of fluoroquinolone-resistant coagulase-negative Staphylococcus. Eur J Ophthalmol. 2006 May-Jun;16(3):359-64.
Responsible Party:
Christopher Ta,
Principal Investigator,
Stanford University
ClinicalTrials.gov Identifier:
NCT00466570
Other Study ID Numbers:
- 8924
First Posted:
Apr 27, 2007
Last Update Posted:
Jun 13, 2013
Last Verified:
Jun 1, 2013