Connect™ CLL: The Chronic Lymphocytic Leukemia Disease Registry
Sponsor
Celgene (Industry)
Overall Status
Completed
CT.gov ID
NCT01081015
Collaborator
(none)
1,494
165
93.4
9.1
0.1
Study Details
Study Description
Brief Summary
The purpose of the Connect™ Chronic Lymphocytic Leukemia (CLL) Disease Registry is to explore the history and real world management of patients diagnosed with CLL, provide insight into the management of CLL, and evaluate the effectiveness of first, second and subsequent therapeutic strategies employed in both the community and academic settings.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Study Design
Study Type:
Observational
Actual Enrollment
:
1494 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
Connect™ CLL: The Chronic Lymphocytic Leukemia Disease Registry
Actual Study Start Date
:
Mar 19, 2010
Actual Primary Completion Date
:
Dec 31, 2017
Actual Study Completion Date
:
Dec 31, 2017
Outcome Measures
Primary Outcome Measures
- Identify and summarize patterns in therapeutic regimens and patient outcomes [up to 8 years]
The primary objective is to 1) describe practice patterns of first line therapy regimens and subsequent therapeutic strategies in patients initiated on therapy for CLL, as well as initiated on second line and subsequent therapies, in the community and academic setting (2) Provide insight into therapeutic regimens and therapy sequence in clinical practice as they relate to clinical outcomes in patients initiated on first-line, second-line or subsequent therapies for CLL.
Secondary Outcome Measures
- Summarize Effectiveness of Treatment Regimens [up to 8 years]
Describe any differences in effectiveness associated with treatment regimens, including first-line regimens and subsequent therapeutic strategies in patients actively treated for CLL
- Health Related Quality of Life Measures Related to Therapeutic Regimens [up to 8 years]
Describe the health-related quality of life of patients actively treated for CLL, and to explore the association of HRQoL with therapeutic regimens, sequences and clinical outcomes.
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Clinical diagnosis with CLL
-
Clinical decision made to initiate first-line therapy, second-line therapy or subsequent line of therapy prior to enrollment into the ConnectTM CLL registry, but within 2 months of enrollment
-
Age≥18 years
-
Willing and able to provide signed informed consent
-
Willing and able to complete patient assessment questionnaires either alone or with minimal assistance from caregivers and/or trained site personnel
Exclusion Criteria:
-
Participation in a clinical study in which study treatment is blinded
-
Patient condition is considered terminal (i.e.<6 months to live)
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | New Hope Cancer & Research Institute | Pomona | California | United States | 91767 |
| 2 | Medical Specialists of the Palm Beaches | Atlantis | Florida | United States | 33462 |
| 3 | University Cancer Institute | Boynton Beach | Florida | United States | 33426 |
| 4 | Thomas Niederman, MD | Boynton Beach | Florida | United States | 33435 |
| 5 | Pasco Hernando Oncology Associates (Kumar) | New Port Richey | Florida | United States | 34652 |
| 6 | Phoebe Putney Memorial Hospital | Albany | Georgia | United States | 31701 |
| 7 | Peachtree Hematology-Oncology Consultants | Atlanta | Georgia | United States | 30318 |
| 8 | Georgia Cancer Specialists | Atlanta | Georgia | United States | 30331 |
| 9 | US Oncology - Dublin Hematology & Oncology | Dublin | Georgia | United States | 31021 |
| 10 | Straub Clinic and Hospital | Honolulu | Hawaii | United States | 96816 |
| 11 | US Oncology - Cancer Care & Hematology Specialists of Chicagoland - Arlington | Arlington Heights | Illinois | United States | 60005 |
| 12 | John H. Stroger, Jr., Hospital of Cook County | Chicago | Illinois | United States | 60612 |
| 13 | Rush University Medical Center | Chicago | Illinois | United States | 60612 |
| 14 | Ingalls Cancer Research Center | Harvey | Illinois | United States | 60426 |
| 15 | Elmhurst Memorial Hospital | Lombard | Illinois | United States | 60148 |
| 16 | Oncology Specialists, S.C. | Niles | Illinois | United States | 60714 |
| 17 | US Oncology - Cancer Care & Hematology Specialists of Chicagoland - Niles | Niles | Illinois | United States | 60714 |
| 18 | Illinois Cancer Care | Peoria | Illinois | United States | 61615 |
| 19 | Orchard Research | Skokie | Illinois | United States | 60076 |
| 20 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 21 | US Oncology - Cancer Care & Hematology Specialists of Chicagoland - Winfield | Winfield | Illinois | United States | 60190 |
| 22 | St. Francis Cancer Research | Beech Grove | Indiana | United States | 46107 |
| 23 | Center for Cancer Care @ Goshen Health Systems | Goshen | Indiana | United States | 46526 |
| 24 | Indiana University Cancer Center Clinical Research Office | Indianapolis | Indiana | United States | 46202 |
| 25 | Cancer Care Partners, LLC | Mishawaka | Indiana | United States | 46545 |
| 26 | Cancer Care Center, Inc. | New Albany | Indiana | United States | 47150 |
| 27 | McFarland Clinic | Ames | Iowa | United States | 50010 |
| 28 | Hematology Oncology Associates of the Quad Cities | Bettendorf | Iowa | United States | 52722 |
| 29 | Iowa Blood and Cancer Care of PCI | Cedar Rapids | Iowa | United States | 52402 |
| 30 | Covenant Clinic | Waterloo | Iowa | United States | 50702 |
| 31 | Cancer Center of Kansas, PA | Wichita | Kansas | United States | 67214 |
| 32 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 33 | Western Maryland Health System, Inc. | Cumberland | Maryland | United States | 21502 |
| 34 | Alliance Hematology Oncology, PA | Westminster | Maryland | United States | 21157 |
| 35 | Capecod Hospital / Davenport Mugar Cancer Center | Hyannis | Massachusetts | United States | 02601 |
| 36 | Fallon Clinic | Worcester | Massachusetts | United States | 01608 |
| 37 | Michigan State University / McLaren Regional Medical Center | Flint | Michigan | United States | 48532 |
| 38 | Cancer and Hematology Centers of Western Michigan | Grand Rapids | Michigan | United States | 49503 |
| 39 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 40 | Duluth Clinic Cancer Center | Duluth | Minnesota | United States | 55805 |
| 41 | Park Nicollet Institute Metro - MN CCOP | Saint Louis Park | Minnesota | United States | 55416 |
| 42 | Park Nicollet Institute - Louisiana Ave. | Saint Louis Park | Minnesota | United States | 55426 |
| 43 | US Oncology - University of Tennessee Cancer Institute - Southaven | Southaven | Mississippi | United States | 38671 |
| 44 | US Oncology - Missouri Cancer Associates | Columbia | Missouri | United States | 65201 |
| 45 | Capitol Comprehensive Cancer Care Clinic | Jefferson City | Missouri | United States | 65109 |
| 46 | St. Joseph Oncology, Inc. | Saint Joseph | Missouri | United States | 64507 |
| 47 | Hematology Oncology Consultants, Inc. | Saint Louis | Missouri | United States | 63136 |
| 48 | St. John's Medical Research Institute | Springfield | Missouri | United States | 65807 |
| 49 | Montana Cancer Institute Foundation | Missoula | Montana | United States | 59802 |
| 50 | Nebraska Hematology Oncology, PC | Lincoln | Nebraska | United States | 68506 |
| 51 | Southeast Nebraska Hematology & Oncology Consultants, PC | Lincoln | Nebraska | United States | 68510 |
| 52 | Southern Nevada Cancer Research Foundation | Las Vegas | Nevada | United States | 89106 |
| 53 | VA Sierra Nevada Healthcare System | Reno | Nevada | United States | 89502 |
| 54 | The Center for Cancer and Hematologic Disease | Cherry Hill | New Jersey | United States | 08003 |
| 55 | Drs. Forte, Schleider, Attas & Condemi, PA | Englewood | New Jersey | United States | 07432 |
| 56 | Charles Farber, MD | Morristown | New Jersey | United States | 07962 |
| 57 | Hematology Oncology of Northern New Jersey | Morristown | New Jersey | United States | 07962 |
| 58 | Steeplechase Cancer Center | Somerville | New Jersey | United States | 08876 |
| 59 | Samuel S Stratton VAMC | Albany | New York | United States | 12208 |
| 60 | Hematology Oncology Associates of Western Suffolk | Bay Shore | New York | United States | 11706 |
| 61 | Eduardo Saponara, MD | Bronxville | New York | United States | 10708 |
| 62 | Bronx River Medical Associates | Bronx | New York | United States | 10467 |
| 63 | Eastchester Center for Cancer Care | Bronx | New York | United States | 10469 |
| 64 | Jonah Cancer Care Center & ECMC | Buffalo | New York | United States | 14215 |
| 65 | Broome Oncology | Johnson City | New York | United States | 13790 |
| 66 | SUNY Upstate Medical University - Adult Program | Syracuse | New York | United States | 14222 |
| 67 | US Oncology - Cancer Centers of North Carolina - Cary | Cary | North Carolina | United States | 27518 |
| 68 | US Oncology - Cancer Centers of North Carolina - Macon | Raleigh | North Carolina | United States | 27607 |
| 69 | US Oncology - Cancer Centers of North Carolina - Falls | Raleigh | North Carolina | United States | 27614 |
| 70 | Legacy Pharma Research | Bismarck | North Dakota | United States | 58501 |
| 71 | Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
| 72 | Summa Health System - Cancer Research Office | Akron | Ohio | United States | 44304 |
| 73 | Gabrail Cancer Center Research | Canton | Ohio | United States | 44718 |
| 74 | Mid Ohio Oncology / Hematology, Inc. | Columbus | Ohio | United States | 43219 |
| 75 | Hematology Oncology Center, Inc. | Elyria | Ohio | United States | 44035 |
| 76 | US Oncology - Willamette Valley Cancer Institute - Eugene | Eugene | Oregon | United States | 97401-8122 |
| 77 | US Oncology - Northwest Cancer Specialists, PC - Portland - Hoyt | Portland | Oregon | United States | 97213-2996 |
| 78 | US Oncology - Northwest Cancer Specialists, PC - Portland - Barnes | Portland | Oregon | United States | 97225 |
| 79 | US Oncology - Northwest Cancer Specialists, PC - Portland - Broadway | Portland | Oregon | United States | 97227 |
| 80 | US Oncology - Willamette Valley Cancer Institute - Springfield | Springfield | Oregon | United States | 97477 |
| 81 | US Oncology - Northwest Cancer Specialists, PC - Tualatin | Tualatin | Oregon | United States | 97062 |
| 82 | Oncology Hematology of Lehigh Valley | Bethlehem | Pennsylvania | United States | 18015 |
| 83 | Consultants in Medical Oncology and Hematology, PC | Drexel Hill | Pennsylvania | United States | 19026 |
| 84 | Gettysburg Cancer Center | Gettysburg | Pennsylvania | United States | 17325 |
| 85 | Andrews and Patel Associates | Harrisburg | Pennsylvania | United States | 17111 |
| 86 | US Oncology - Medical Oncology Associates (Nahar) | Kingston | Pennsylvania | United States | 18704 |
| 87 | Lancaster Cancer Center | Lancaster | Pennsylvania | United States | 17605 |
| 88 | Berks Hematology Oncology Associates | Reading | Pennsylvania | United States | 19612 |
| 89 | Hematology & Oncology Associates of Rhode Island | Cranston | Rhode Island | United States | 02920 |
| 90 | Charleston Hematology Oncology Associates, PA | Charleston | South Carolina | United States | 29403 |
| 91 | South Carolina Oncololgy Associates, PA | Columbia | South Carolina | United States | 29210 |
| 92 | US Oncology - Cancer Centers of the Carolinas - Easley | Easley | South Carolina | United States | 29640 |
| 93 | US Oncology - Cancer Centers of the Carolinas - Butternut | Greenville | South Carolina | United States | 29605 |
| 94 | US Oncology - Cancer Centers of the Carolinas - West Faris | Greenville | South Carolina | United States | 29605 |
| 95 | US Oncology - Cancer Centers of the Carlinas - Eastside | Greenville | South Carolina | United States | 29615 |
| 96 | US Oncology - Cancer Centers of the Carolinas - Seneca | Seneca | South Carolina | United States | 29672 |
| 97 | US Oncology - Cancer Centers of the Carolinas - Spartanburg | Spartanburg | South Carolina | United States | 29307 |
| 98 | Sanford Clinic | Sioux Falls | South Dakota | United States | 57104 |
| 99 | US Oncology - University of Tennessee Cancer Institute - Bartlett | Bartlett | Tennessee | United States | 38133 |
| 100 | Family Cancer Center, PLLC | Collierville | Tennessee | United States | 38017 |
| 101 | US Oncology - University of Tennessee Cancer Institute - Germantown | Germantown | Tennessee | United States | 38138 |
| 102 | US Oncology - University of Tennessee Cancer Institute - Memphis | Memphis | Tennessee | United States | 38104 |
| 103 | SCRI | Nashville | Tennessee | United States | 37203 |
| 104 | US Oncology - Texas Cancer Center - Abilene (South) | Abilene | Texas | United States | 79606 |
| 105 | US Oncology - Texas Oncology, PA - Amarillo | Amarillo | Texas | United States | 79106 |
| 106 | US Oncology - Texas Oncology - Arlington South | Arlington | Texas | United States | 76014 |
| 107 | US Oncology - Texas Oncology, PA - Bedford | Bedford | Texas | United States | 76022 |
| 108 | St. Joseph Regional Cancer Center | Bryan | Texas | United States | 77802 |
| 109 | Scott & White Clinic | College Station | Texas | United States | 77802 |
| 110 | South Texas Institute of Cancer | Corpus Christi | Texas | United States | 78405 |
| 111 | Coastal Bend Cancer Center | Corpus Christi | Texas | United States | 78463 |
| 112 | US Oncology - Texas Oncology, PA - Dallas | Dallas | Texas | United States | 75231 |
| 113 | US Oncology - El Paso Cancer Treatment Center - West | El Paso | Texas | United States | 79902 |
| 114 | US Oncology - El Paso Cancer Treatment Center | El Paso | Texas | United States | 79902 |
| 115 | US Oncology - Texas Oncology, PA - Fort Worth | Fort Worth | Texas | United States | 76104 |
| 116 | US Oncology - Southwest Fort Worth Cancer Center | Fort Worth | Texas | United States | 76132 |
| 117 | US Oncology - Texas Oncology - Grapevine | Grapevine | Texas | United States | 76051 |
| 118 | Oncology Consultants | Houston | Texas | United States | 77024 |
| 119 | MD Anderson Cancer Center | Houston | Texas | United States | 77030 |
| 120 | US Oncology - San Antonio Tumor & Blood Clinic - Kerrville | Kerrville | Texas | United States | 78028 |
| 121 | Wilford Hall Medical Center | Lackland Air Force Base | Texas | United States | 78236 |
| 122 | US Oncology - Longview Cancer Center | Longview | Texas | United States | 75601 |
| 123 | Joe Arrington Cancer Research and Treatment Center | Lubbock | Texas | United States | 79410 |
| 124 | US Oncology - Texas Oncology - McAllen | McAllen | Texas | United States | 78503 |
| 125 | US Oncology - Texas Oncology - Mesquite | Mesquite | Texas | United States | 75150 |
| 126 | US Oncology - Allison Cancer Center | Midland | Texas | United States | 79701 |
| 127 | US Oncology - Texas Oncology - Paris | Paris | Texas | United States | 75460-5004 |
| 128 | US Oncology - Cancer Care Centers of South Texas | San Antonio | Texas | United States | 78217 |
| 129 | US Oncology - San Antonio Tumor & Blood Clinic - M. Oak | San Antonio | Texas | United States | 78258-3912 |
| 130 | US Oncology - Texas Oncology - Sherman | Sherman | Texas | United States | 75090-0504 |
| 131 | Scott & White Healthcare Department of Research | Temple | Texas | United States | 76508 |
| 132 | ETMC dba Blood and Cancer Center - East Texas | Tyler | Texas | United States | 75701 |
| 133 | ETMC dba Tyler Hematology Oncology | Tyler | Texas | United States | 75701 |
| 134 | US Oncology - Texas Oncology - Tyler | Tyler | Texas | United States | 75702 |
| 135 | US Oncology - Texas Oncology Cancer Care and Research Center | Waco | Texas | United States | 76712 |
| 136 | US Oncology - Texas Oncology - Weslaco | Weslaco | Texas | United States | 78596 |
| 137 | US Oncology - Texoma Cancer Center | Wichita Falls | Texas | United States | 76310 |
| 138 | Central Utah Clinic | American Fork | Utah | United States | 84003 |
| 139 | Northern Utah Associates | Ogden | Utah | United States | 84403 |
| 140 | US Oncology - Arlington Fairfax Hematology Oncology | Arlington | Virginia | United States | 22205 |
| 141 | US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Christiansburg | Christiansburg | Virginia | United States | 24073 |
| 142 | US Oncology - Fairfax Northern VA Hem-Onc PC | Fairfax | Virginia | United States | 22031 |
| 143 | US Oncology - Fairfax - Northern Virginia Hematology-Oncology, PC - Gainesville | Gainesville | Virginia | United States | 20155 |
| 144 | US Oncology - Fairfax - Northern Virginia Hem-Onc, PC - Leesburg | Leesburg | Virginia | United States | 20176 |
| 145 | US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Low Moor | Low Moor | Virginia | United States | 24457 |
| 146 | US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Roanoke | Roanoke | Virginia | United States | 24014 |
| 147 | US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Salem | Salem | Virginia | United States | 24153 |
| 148 | US Oncology - Shenandoah Oncology - Winchester | Winchester | Virginia | United States | 22601 |
| 149 | US Oncology - Fairfax - Northern Virginia Hem-Onc, PC - Woodbridge | Woodbridge | Virginia | United States | 22191 |
| 150 | US Oncology - Onc and Hem Assoc of Southwest VA, Inc - Wytheville | Wytheville | Virginia | United States | 24382 |
| 151 | Peace Health Medical Group | Bellingham | Washington | United States | 98226 |
| 152 | US Oncology - Puget Sound Cancer Center - Edmonds | Edmonds | Washington | United States | 98133 |
| 153 | Providence Everett Medical Center | Everett | Washington | United States | 98201 |
| 154 | Columbia Basin Hematology and Oncology | Kennewick | Washington | United States | 99337 |
| 155 | US Oncology - Puget Sound Cancer Center - Seattle | Seattle | Washington | United States | 98133 |
| 156 | US Oncology - Cancer Care Northwest - Sherman | Spokane | Washington | United States | 99202 |
| 157 | Medical Oncology Associates PS | Spokane | Washington | United States | 99208 |
| 158 | US Oncology - Cancer Care Northwest - Holland | Spokane | Washington | United States | 99218 |
| 159 | US Oncology - Cancer Care Northwest - Mission | Spokane | Washington | United States | 99218 |
| 160 | US Oncology - Northwest Cancer Specialists, PC - Vancouver - 136th St. | Vancouver | Washington | United States | 98684 |
| 161 | US Oncology - Northwest Cancer Specialists, PC - Vancouver - 134th St | Vancouver | Washington | United States | 98686 |
| 162 | Providence St. Mary Regional Cancer Center | Walla Walla | Washington | United States | 99362 |
| 163 | US Oncology - Yakima Valley Memorial Hospital/North Star Lodge (Boyd) | Yakima | Washington | United States | 98902 |
| 164 | St. Vincent Hospital/Green Bay Oncology | Green Bay | Wisconsin | United States | 54301 |
| 165 | Waukesha Memorial Hospital | Waukesha | Wisconsin | United States | 53188 |
Sponsors and Collaborators
- Celgene
Investigators
- Study Director: Kenneth Foon, MD, Celgene Corporation
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.Responsible Party:
Celgene
ClinicalTrials.gov Identifier:
NCT01081015
Other Study ID Numbers:
- Connect™ CLL
First Posted:
Mar 5, 2010
Last Update Posted:
May 12, 2020
Last Verified:
May 1, 2020
Keywords provided by Celgene
Additional relevant MeSH terms: