Construction of Gynecological Tumor Organoids
Study Details
Study Description
Brief Summary
This study focuses on the construction of a biological sample library for organoids and tumor tissues in gynecological tumors.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Explore the construction and maintenance of a large-scale queue of gynecological tumor organoids. Beijing Daxiang Technology Co., Ltd. provides corresponding technical support and chip design. Gynecological oncology center provides tumor samples, clinical information, and pathological support, and biological sample library provides technical support, storage space, and quality management.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| cohort of cervical cancer organoids organoids derived from cervical cancer |
Other: construction of organoids from gynecological tumor
organoids construction
|
| cohort of endometrial cancer organoids organoids derived from endometrial cancer |
Other: construction of organoids from gynecological tumor
organoids construction
|
| cohort of ovarian cancer organoids organoids derived from ovarian cancer |
Other: construction of organoids from gynecological tumor
organoids construction
|
| cohort of vulva cancer organoids organoids derived from vulva cancer |
Other: construction of organoids from gynecological tumor
organoids construction
|
| cohort of vaginal cancer organoids organoids derived from vaginal cancer |
Other: construction of organoids from gynecological tumor
organoids construction
|
| cohort of gestational trophoblastic tumor organoids organoids derived from gestational trophoblastic tumor |
Other: construction of organoids from gynecological tumor
organoids construction
|
Outcome Measures
Primary Outcome Measures
- Construction of BioBank [one year]
BioBank including organoids banks, tissue banks, PDX banks, immune cell banks, and primary banks from other tissue sources
Secondary Outcome Measures
- Drug sensitivity detection based on organoids banks [one year]
Exploring drug sensitivity detection in gynecological tumors based on organoid libraries
- Exploring the molecular mechanism based on organoids banks [one year]
Exploring the molecular mechanism of gynecological tumor pathogenesis based on organoid banks
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age of 18 or older, an informed consent form is provided;
-
The preoperative tumor burden assessment and intraoperative researcher team believe that sampling is feasible;
-
Having relevant requirements for sample library storage;
-
Surgical treatment at Peking Union Medical College Hospital.
Exclusion Criteria:
-
Unable to meet all inclusion criteria;
-
The research team considers any situations or considerations that may hinder normal pathological assessment.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Peking Union Medical College Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- K4903 G&O organoids