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Effects of St. John's Wort on the Effectiveness of Oral Contraceptives

Sponsor
National Center for Complementary and Integrative Health (NCCIH) (NIH)
Overall Status
Completed
CT.gov ID
NCT00026013
Collaborator
(none)
25
Enrollment
1
Location
24
Duration (Months)
1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to evaluate the effects of a common herbal remedy, St. John's Wort, on the effectiveness of birth control pills. St. John's Wort has recently been shown to increase metabolism of some drugs. If it could increase metabolism of oral contraceptives as well, it may increase the risk of contraceptive failure and unintended pregnancy. Study participants will be evaluated for risk of ovulation on oral contraceptives before and during simultaneous therapy with St. John's Wort.

Condition or Disease Intervention/Treatment Phase
  • Drug: hypericum perforatum
 N/A

Detailed Description

See Brief Summary

Study Design

Study Type:
Interventional
Allocation:
Non-Randomized
Intervention Model:
Single Group Assignment
Masking:
Single
Primary Purpose:
Treatment
Official Title:
Effects of Hypericum Perforatum on Effectiveness of Oral Contraceptives
Study Start Date :
Jan 1, 2002
Study Completion Date :
Jan 1, 2004

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 40 Years
    Sexes Eligible for Study:
    Female
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Women taking or willing to take low dose oral contraceptives for 5 months

    • No contraindications to hormonal contraception

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Columbia University Department of Obstetrics & Gynecology New York New York United States 10032

    Sponsors and Collaborators

    • National Center for Complementary and Integrative Health (NCCIH)

    Investigators

    • Principal Investigator: Patricia Murphy, DrPh, Columbia University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00026013
    Other Study ID Numbers:
    • R21AT000836-01
    First Posted:
    Nov 6, 2001
    Last Update Posted:
    Aug 18, 2006
    Last Verified:
    Jul 1, 2006
    Keywords provided by , ,
    contraception
    hormonal contraception
    herbal remedies
    hypericum perforatum
    contraceptive effectiveness

    Study Results

    No Results Posted as of Aug 18, 2006