RedNeumon: Convolutional Neural Network Model to Detect COVID-19 Infection

Sponsor
Fundacion Clinica Valle del Lili (Other)
Overall Status
Completed
CT.gov ID
NCT05722665
Collaborator
Universidad Autonoma de Occidente (Other)
3,599
1
15.1
237.6

Study Details

Study Description

Brief Summary

The purpose of this study is to design a Convolutional Neural Network (CNN) and apply an attention model to help differentiate pneumonia due to SARS-CoV-2, pneumonia due to other causes and normal chest radiographs in clinical practice using a bank of digital chest images from a high complexity health facility in Cali, Colombia.

Condition or Disease Intervention/Treatment Phase
  • Other: Categorization of chest xrays images

Detailed Description

This work focuses on developing an optimized transformer model to classify x-ray images into normal, abnormal with pneumonia caused by SARS-CoV-2, and abnormal with pneumonia due to other sources. Using a private dataset, the developed model can detect all three cases with high accuracy. Other datasets were used to confirm the model's accuracy, which provided positive results. The model is based on self-attention mechanisms and convolutional layers, which have been shown to improve performance when combined. The proposed model was tested on various datasets and reached satisfactory results in terms of accuracy and speed.

Moreover, the model can easily apply to different tasks, as it can quickly be retrained with new datasets. The proposed model combines Convolutional Neural Networks (CNNs) and optimized Attention Mechanisms. Modifications to the attention mechanisms were made to accelerate the algorithm by implementing a CNN for the linear projection. We obtained an accuracy of 80.1% for the model and a precision of 88%, 79.2%, and 72% for pneumonia caused by SARS-CoV-2, pneumonia due to other sources, and normal x-ray, respectively.

Study Design

Study Type:
Observational
Actual Enrollment :
3599 participants
Observational Model:
Other
Time Perspective:
Retrospective
Official Title:
The Predictive Capacity of a Convolutional Neural Network Model to Detect Viral Pneumonia in Adult Patients With SARS-CoV-2 Infection (COVID-19) in Cali, Colombia
Actual Study Start Date :
Aug 26, 2021
Actual Primary Completion Date :
Nov 30, 2022
Actual Study Completion Date :
Nov 30, 2022

Arms and Interventions

Arm Intervention/Treatment
Normar chest radiographs

X-rays without alterations in the lung parenchyma

Other: Categorization of chest xrays images
Use of Convolutional Neural Network Model to categorize chest xrays images in each group.

COVID-19 chest radiographs

X-rays belonging to patients with a diagnosis of COVID-19 confirmed by positive Reverse Transcriptase polymerase chain reaction (RT-PCR) and/or presence of antibodies to COVID-19 and/or positive COVID-19 viral antigen.

Other: Categorization of chest xrays images
Use of Convolutional Neural Network Model to categorize chest xrays images in each group.

Other pneumonia chest radiographs

X-rays belonging to patients with a diagnosis of pneumonia other than COVID-19

Other: Categorization of chest xrays images
Use of Convolutional Neural Network Model to categorize chest xrays images in each group.

Outcome Measures

Primary Outcome Measures

  1. COVID19 pneumonia chest radiograph identifyed [month 8]

    Development and determination of the predictive capacity of a Convolutional Neural Network model to detect viral pneumonia in chest radiographs of adult patients with acute respiratory disease secondary to SARS-COV-2 infection.

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • Chest radiographs from patients without COVID-19 or other pneumonia took before the pandemic start date (January 2020)

  • Chest radiographs from patients with COVID-19 confirmed by positive Reverse Transcriptase polymerase chain reaction (RT-PCR) and/or presence of antibodies to COVID-19 and/or positive COVID-19 viral antigen.

  • Chest radiographs from patients without COVID-19 confirmed by a negative Reverse Transcriptase polymerase chain reaction (RT-PCR) and other pneumonia diagnoses taken before the pandemic start date (January 2020)

Exclusion Criteria:
  • N/A

Contacts and Locations

Locations

Site City State Country Postal Code
1 Fundacion Valle del Lili Cali Valle Del Cauca Colombia 760001

Sponsors and Collaborators

  • Fundacion Clinica Valle del Lili
  • Universidad Autonoma de Occidente

Investigators

  • Principal Investigator: Liliana Fernandez, M.D, Fundacion Clinica Valle del Lili

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Fundacion Clinica Valle del Lili
ClinicalTrials.gov Identifier:
NCT05722665
Other Study ID Numbers:
  • 1805
First Posted:
Feb 10, 2023
Last Update Posted:
Feb 10, 2023
Last Verified:
Feb 1, 2023
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Fundacion Clinica Valle del Lili
Additional relevant MeSH terms:

Study Results

No Results Posted as of Feb 10, 2023