COPD Co-infection With Tuberculosis on Th17 Cell Differentiation
Study Details
Study Description
Brief Summary
This project will observe and follow up the changes of pulmonary function and CT in patients with smoking combined with pulmonary tuberculosis, and measure the ratio of Th1 cells, Th17 cells, macrophages and neutrophils and the secretion of factors such as TNF-α, IFN-γ and IL-17 in pulmonary blood and alveolar lavage fluid.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Chronic obstructive pulmonary disease (COPD) and tuberculosis are major global health problems, and acquired and acquired immunity play an important role in COPD and tuberculosis, and there is an interaction between COPD and tuberculosis, but the exact mechanism is not clear. Pre-existing TB infection is an independent risk factor for COPD and can aggravate pulmonary function and increase hospitalization and mortality in COPD patients. In COPD patients, Th1 and Th17 cells are involved in the development of COPD and emphysema through activation of macrophages and recruitment of neutrophils, while matrix metalloproteinases (MMPs) of macrophage and neutrophil origin are involved in the formation of tuberculosis cavities, and cytokines such as TNF-α, IFN-γ, IL-17 are involved in the mechanism of their destruction, IL-17 restricts the expression of HIF-1α to inhibit the development of TB granulomas, and CT analysis revealed that combined TB exacerbates emphysema in COPD patients. The above evidence suggests that tuberculosis plays an important role in the formation of emphysema in COPD. In this project, we will observe and follow up the changes of pulmonary function and CT in patients with smoking combined with pulmonary tuberculosis, and examine the ratio of Th1 cells, Th17 cells, macrophages and neutrophils and the secretion of TNF-α, IFN-γ, and IL-17 in pulmonary blood and alveolar lavage fluid.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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COPD combined with TB group COPD combined with pulmonary TB infection |
Other: No intervention
No intervention
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COPD non-TB control group COPD combined without pulmonary TB infection |
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TB non-COPD control group pulmonary TB infection without COPD |
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Non-smoking non-TB control group Non-smoking without pulmonary TB infection |
Outcome Measures
Primary Outcome Measures
- Differentiation of Th17 cells [Day 1]
Distribution of T cell subtypes, including CD4+, CD8+ T cells and Th17 cells, in blood specimens and alveolar lavage fluid by flow cytometry
Eligibility Criteria
Criteria
Inclusion Criteria:
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Clinical diagnosis of COPD
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age ≧ 40
Exclusion Criteria:
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Presence of other chronic respiratory diseases other than COPD, such as asthma, bronchiectasis, interstitial lung disease, etc.
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History of chest and lung surgery.
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History of malignancy.
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Autoimmune disease.
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Long-term oral glucocorticoids, immunosuppressants and inhaled glucocorticoids.
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Mental abnormalities, cognitive impairment, inability to cooperate with pulmonary function and other tests.
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Acute stage of infection, such as lung infection, urinary tract infection and gastrointestinal tract infection, etc.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Peking University Third Hospital | Beijing | Beijing | China | 100191 |
Sponsors and Collaborators
- Peking University Third Hospital
- Beijing Geriatric Hospital
Investigators
- Principal Investigator: Yongchang Sun, MD, Peking University 3rd Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- M2017390