Complement Activation and Central Nervous System Injury After Coronary Artery Surgery
Study Details
Study Description
Brief Summary
The impact of the postoperative inflammatory response on the central nervous system after cardiac surgery is uncertain.
The goal of this study was to evaluate the role of complement activation on cellular brain injury and neurological functioning in patients undergoing coronary artery surgery. In addition, the effect of complement activation on the cerebral vasomotricity was assessed.
Because receptors to activated complement are present on astrocytes, the heparin-coated cardiopulmonary bypass that reduces complement activation should minimize these postoperative neurological adverse events. Heparin-coating might also influence blood flow velocity in cerebral arteries postoperatively if complement activation mediates cardiopulmonary bypass induced cerebral vasomotor dysfunction.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Closed cardiopulmonary bypass and controlled suctions of pericardial shed blood were standardized in all patients.
Bedside transcranial Doppler examination served to evaluate the development of cerebral vasomotor dysfunction in a subgroup of patients.
Study Design
Outcome Measures
Primary Outcome Measures
- sC5b-9 release []
- s100beta release []
Secondary Outcome Measures
- changes in neuropsychological functioning (z scores of cognitive domains) []
- blood flow velocity in the middle cerebral artery (subgroup) []
Eligibility Criteria
Criteria
Inclusion Criteria:
- men undergoing coronary artery bypass surgery using cardiopulmonary bypass
Exclusion Criteria:
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clinical conditions expected to potentially influence the magnitude of the systemic inflammatory response after surgery such as open heart surgery, women because they show higher complement activation after surgery, redo cases, organ dysfunction as defined by the Euroscore such as chronic airway disease or renal dysfunction with creatinine level above 200 µmol/L, patients with left ventricular ejection fraction below 35%, diabetes mellitus under insulin therapy prior to the operation, presence of active inflammatory disease or patients taking anti-inflammatory drugs (except acetylsalicylic acid).
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significant carotid artery stenoses (>70%) at the preoperative echo-doppler examination, evidence of preexisting neurologic or psychiatric disease, existence of preoperative neuropsychological impairment as defined by preoperative Mini-Mental State Examination (MMSE) below 27, and alcohol addiction.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- University Hospital, Angers
Investigators
- Principal Investigator: Christophe BAUFRETON, MD PhD, University Hospital of Angers, France
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- PL 97-01