SPIRIT 48: Abbott Next Generation Drug Eluting Stent 48mm Study

Sponsor

Abbott Medical Devices (Industry)

Overall Status

Active, not recruiting

CT.gov ID

NCT04282148

Collaborator

(none)

107

Enrollment

Locations

Arm

47.5

Anticipated Duration (Months)

3.7

Patients Per Site

0.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this SPIRIT 48 study is to evaluate the safety and effectiveness of the ABT NG DES 48 in improving coronary artery luminal diameter in subjects with coronary artery disease (CAD) due to de novo native coronary artery long lesions.

Condition or Disease	Intervention/Treatment	Phase
Coronary Artery Disease	Device: ABT NG DES 48 EECSS	N/A

Detailed Description

The SPIRIT 48 mm study is a prospective, single arm, open-label, multi-center global (US and outside of US) clinical investigation to evaluate the safety and effectiveness of the ABT Next Generation Drug Eluting Stent 48 mm everolimus-eluting coronary stent system (EECSS) (called "ABT NG DES 48") in up to 107 subjects at up to 33 sites globally. The clinical outcomes from the SPIRIT 48 study will be compared to a performance goal (PG) established using historical control data from the SPIRIT Prime Long Lesion Registry. This clinical investigation will be conducted under an investigational device exemption (IDE) and is intended to support market approval of the ABT NG DES 48 in the United States.

Study Design

Study Type:

Interventional

Actual Enrollment :

107 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Intervention Model Description:

Prospective, multi-center, global (US and OUS)Prospective, multi-center, global (US and OUS)

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Clinical Investigation to Assess the Abbott Next Generation Drug Eluting Stent 48mm Everolimus Eluting Coronary Stent System (EECSS) in Treatment of de Novo Native Coronary Artery Disease

Actual Study Start Date :

Jun 17, 2020

Anticipated Primary Completion Date :

Sep 1, 2022

Anticipated Study Completion Date :

Jun 1, 2024

Arms and Interventions

Arm	Intervention/Treatment
Experimental: ABT NG DES 48 EECSS Participants will receive ABT NG DES 48 EECSS device	Device: ABT NG DES 48 EECSS Each participant will receive ABT NG DES 48 EECSS with appropriate diameter

Arm

Intervention/Treatment

Experimental: ABT NG DES 48 EECSS

Participants will receive ABT NG DES 48 EECSS device

Device: ABT NG DES 48 EECSS

Each participant will receive ABT NG DES 48 EECSS with appropriate diameter

Outcome Measures

Primary Outcome Measures

Number of Participants with Target Lesion Failure (TLF) [1 year]
Target Lesion Failure (TLF) is defined as the composite rate of cardiac death (CD), target vessel myocardial infarction [TV-MI] (per SCAI MI definition), and clinically indicated target lesion revascularization [CI-TLR])

Secondary Outcome Measures

Number of Participants with Target Lesion Failure (TLF) [In-hospital 6 to 12 hours post procedure]
Target Lesion Failure (TLF) is defined as the composite rate of cardiac death (CD), target vessel myocardial infarction [TV-MI] (per SCAI MI definition), and clinically indicated target lesion revascularization [CI-TLR])
Number of Participants with Target Lesion Failure (TLF) [30 days]
Target Lesion Failure (TLF) is defined as the composite rate of cardiac death (CD), target vessel myocardial infarction [TV-MI] (per SCAI MI definition), and clinically indicated target lesion revascularization [CI-TLR])
Number of Participants with Target Lesion Failure (TLF) [180 days]
Target Lesion Failure (TLF) is defined as the composite rate of cardiac death (CD), target vessel myocardial infarction [TV-MI] (per SCAI MI definition), and clinically indicated target lesion revascularization [CI-TLR])
Number of Participants with Target Lesion Failure (TLF) [2 years]
Target Lesion Failure (TLF) is defined as the composite rate of cardiac death (CD), target vessel myocardial infarction [TV-MI] (per SCAI MI definition), and clinically indicated target lesion revascularization [CI-TLR])

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

General Inclusion Criteria:

Subject must be at least 18 years of age.
Subject or a legally authorized representative must provide written informed consent prior to any study related procedure, per site requirements.
Subject must have evidence of myocardial ischemia (e.g., unstable angina, post-infarct angina, stable angina or silent ischemia) suitable for non-emergent PCI. Subject with stable angina or silent ischemia must have objective sign of ischemia as suggested by one of the following,

Abnormal stress or imaging stress test
Abnormal computed tomography-fractional flow reserve (CT-FFR)
Stenosis by visual estimation ≥ 70%
Abnormal pressure-derived indexes (FFR, instantaneous wave-free ratio [iFR], or relative flow reserve [RFR])

Subject must be an acceptable candidate for coronary artery bypass graft (CABG) surgery.
Subject must agree not to participate in any other clinical study for a period of one year following the index procedure.

Angiographic Inclusion Criteria:

Only one de novo target lesion in native coronary artery is allowed to be treated with the investigational stent.

• One additional non-target lesion can be treated if it is located in a different epicardial coronary vessel and NOT in left main coronary artery. The non-target lesion must be treated first and must be deemed an angiographic success.

The target lesion must be located in a native coronary artery with:

Visually estimated reference vessel diameter (RVD) of ≥ 2.5 mm and ≤ 4.25 mm.
Visually estimated lesion length of > 32 mm and ≤ 44 mm, and able to be covered by a single ABT NG DES 48.

Multiple focal de novo lesions in an epicardial coronary vessel are allowed if the lesions can be covered by one stent. Multiple focal de novo lesions will be counted as a single lesion.

Visually estimated diameter stenosis of > 50% and < 100% with a Thrombolysis in Myocardial Infarction (TIMI) flow of ≥ 1

Stable angina or silent ischemia subjects must have stenosis ≥ 70%, or abnormal pressure-derived physiological indices (FFR, iFR, or RFR), unless abnormal stress or imaging stress test is evidenced.

General Exclusion Criteria:

Subject has known hypersensitivity or contraindication to device material and its degradants (everolimus, cobalt, chromium, nickel, tungsten, acrylic and fluoropolymers, etc.), or has known contrast sensitivity.
Subject has known hypersensitivity or contraindication to aspirin, heparin/bivalirudin, P2Y12 inhibitors (clopidogrel /prasugrel /ticagrelor), and therefore cannot be adequately pre-medicated.
Subject has a planned surgery or procedure necessitating discontinuation of aspirin or P2Y12 inhibitor within 12 months following index procedure.
Subject is receiving or will require chronic anticoagulation therapy (e.g., coumadin, dabigatran, apixaban, rivaroxaban or any other agent for any reason).
Pregnant or nursing subjects and those who plan pregnancy in the period up to 1 year following index procedure. Female subjects of child-bearing potential must have a negative pregnancy test done within 7 days prior to the index procedure per site standard test.
Subject had an acute myocardial infarction (AMI) within 48 hours of the index procedure with either of the situations below:

The subject is currently experiencing clinical symptoms consistent with new onset AMI, such as nitrate-unresponsive prolonged chest pain with ischemic electrocardiogram (ECG) changes
Elevated cardiac biomarker values have not returned to within normal limits at the time of index procedure.

Subject has a left ventricular ejection fraction (LVEF) < 30% within 3 months prior to the index procedure, that was documented by any method.
Subject is expected to require percutaneous mechanical cardiac support at the index procedure.
Prior PCI within the target vessel during the last 12 months prior to consent.
Prior PCI within the non-target vessel or any peripheral intervention during the last 30 days prior to consent.
At the index procedure, subject is identified to require planned stenting procedure (including staged procedures) or CABG after the index procedure.
Subject has received a solid organ transplant which is functioning or is active on a waiting list for any solid organ transplants with expected transplantation within 24 months.
Subject has a malignancy that is not in remission.
Subject is receiving immunosuppressant therapy or has known life-threatening immunosuppressive or severe autoimmune disease (e.g., human immunodeficiency virus, systemic lupus erythematosus, etc.). Note: corticosteroids are not included as immunosuppressant therapy, diabetes mellitus is not regarded as autoimmune disease
Subject has previously received or is scheduled to receive radiotherapy to a coronary artery (vascular brachytherapy), or the chest/mediastinum.
Subject has a platelet count < 100,000 cells/mm^{3 or > 700,000 cells/mm}3.
Subject has renal insufficiency as defined as an estimated glomerular filtration rate (GFR) < 30 ml/min/1.73m^2 or dialysis at the time of consent.
Subject is high risk of bleeding for any reason; has a history of bleeding diathesis or coagulopathy; has had a significant gastro-intestinal or significant urinary bleed within the past six months.
Subject has had a cerebrovascular accident or transient ischemic neurological attack (TIA) within the past 6 months, or any prior intracranial bleed, or any permanent neurologic defect, or any known intracranial pathology (e.g. aneurysm, arteriovenous malformation, etc.).
Subject has extensive peripheral vascular disease that precludes safe 6 French sheath insertion. Note: femoral arterial disease does not exclude the subject if radial access may be used.
Subject has life expectancy < 2 years.
Subject is, in the opinion of the Investigator or designee, unable to comply with the requirements of the study protocol or is unsuitable for the study for any reason. This includes completion of Subject Reported Outcome instruments.
Subject is currently participating in another clinical investigation (except for non-invasive observational studies) that has not yet completed its primary endpoint.
Subject intends to participate in another investigational drug or device clinical investigation (except for non-invasive observational studies) within 12 months after the index procedure.
Subject has other medical illness (e.g., cancer or congestive heart failure) or known history of substance abuse (alcohol, cocaine, heroin etc.) that may cause non-compliance with the protocol, confound the data interpretation or is associated with a limited life expectancy less than 2 years.
Presence of other anatomic or comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements, or impact the scientific soundness of the clinical investigation results.
Subject has active symptoms and/or a positive test result of COVID-19 or other rapidly spreading novel infectious agent within the prior 2 months.

Angiographic Exclusion Criteria:

Target lesion/vessel meets any of the following criteria:

Prevents complete angioplasty balloon (plain old balloon angioplasty [POBA], scoring balloon, or cutting balloon) inflation, such as:
Heavy calcified lesion
Requires additional device for lesion preparation (e.g. rotablator or laser).
Anatomy proximal to or within the lesion that prevents proper placement of delivery system:
Extreme angulation (≥ 90°) proximal to or within the target lesion.
Excessive tortuosity (≥ two 45° angles) proximal to or within the target lesion.
Involves a bifurcation of which the side branch will be jailed by the struts and requiring side branch pre-dilatation by Kissing Balloon Technique, and/or stenting
Is located:
In left main or there is a ≥30% diameter stenosis in the left main (unless the left main lesion is a protected left main (i.e. a patent bypass graft to the left anterior descending coronary artery [LAD] and/or left circumflex coronary artery [LCX] arteries is present), and there is no intention to treat the protected left main lesion.
Within 3 mm of the origin of the LAD or LCX.
Within 3 mm of aorto-ostial right coronary artery (RCA).
In a bypass graft or distal to anastomotic site of bypass graft.
With total occlusion (TIMI flow 0), prior to crossing with the wire.
Contains thrombus
The subject has been previously treated with a stent within 1-year prior to the index procedure such that the ABT NG DES 48 would need to cross the stent to reach the target lesion.

Unsuccessful target lesion pre-dilatation, defined as the presence of one or more of the following:

Failed for a full inflation of the pre-dilatation balloon.
TIMI flow grade <3 (per visual estimation).
Any angiographic complication (e.g. distal embolization, no-reflow)
Any dissection National Heart, Lung, and Blood Institute (NHLBI) grade D-F.
Any chest pain lasting > 5 minutes.
Any ST-segment depression or elevation lasting > 5 minutes.
Side branch requires additional dilatation/stenting caused by plaque shift, carina shift or may require additional dilatation/stenting after stent implantation, per the operator's assessment.

Non-target lesion meets any of the following criteria:

Is located in the target vessel
Is located in the left main location
Is restenotic from a previous stent implantation
Is located within a saphenous vein graft or an arterial graft
Is with a TIMI flow 0 (total occlusion) prior to guide wire crossing
Involves a complex bifurcation that needs two-stent strategy.

Treatment of non-target lesion is not deemed successful.

Note: A successful treatment is defined as a treatment resulted in a mean lesion diameter stenosis < 30% in 2 near-orthogonal projections with TIMI 3 flow, as visually assessed by the physician, without the occurrence of prolonged chest pain or ECG changes consistent with MI.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	HonorHealth	Scottsdale	Arizona	United States	85258
2	Scripps Memorial Hospital - La Jolla	La Jolla	California	United States	92037
3	UCLA Medical Center Santa Monica	Santa Monica	California	United States	90404
4	The Cardiac & Vascular Institute Research Foundation, LLC	Gainesville	Florida	United States	32605
5	Shands at the University of Florida	Gainesville	Florida	United States	32610
6	Via Christi Regional Medical Center - St. Francis Campus	Wichita	Kansas	United States	67214
7	Cardiovascular Research Institute of Kansas	Wichita	Kansas	United States	67226
8	Massachusetts General Hospital	Boston	Massachusetts	United States	02114
9	Minneapolis Heart Institute	Minneapolis	Minnesota	United States	55407
10	North Mississippi Medical Center	Tupelo	Mississippi	United States	38801
11	St. Patrick Hospital	Missoula	Montana	United States	59802
12	Mount Sinai Hospital	New York	New York	United States	10019
13	NC Heart & Vascular Research	Raleigh	North Carolina	United States	27607
14	Wake Forest University Medical Center Clinical Sciences	Winston-Salem	North Carolina	United States	27157
15	The Lindner Center	Cincinnati	Ohio	United States	45219
16	St. Vincent Mercy Medical Center	Toledo	Ohio	United States	43608
17	Providence Heart & Vascular Institute	Portland	Oregon	United States	97225
18	Pinnacle Health System	Harrisburg	Pennsylvania	United States	17105
19	Greenville Health System	Greenville	South Carolina	United States	29605
20	Baylor Scott & White Heart & Vascular Hospital	Dallas	Texas	United States	75226
21	The Heart Hospital Baylor Plano	Plano	Texas	United States	75093
22	Wheeling Hospital	Wheeling	West Virginia	United States	26003
23	Liverpool Hospital	Liverpool	New South Wales	Australia	2170
24	The Prince Charles Hospital	Chermside	Queensland	Australia	4032
25	Royal North Shore Hospital	St Leonards		Australia	2065
26	Chang Gung Memorial Hospital	Linkou	North Taiwan	Taiwan	333
27	National Taiwan University Hospital	Taipei	North Taiwan	Taiwan	10002
28	Cheng Hsin General Hospital	Taipei	North Taiwan	Taiwan	112
29	Kaohsiung Chang Gung Memorial Hospital	Kaohsiung	South Taiwan	Taiwan	83301

Sponsors and Collaborators

Abbott Medical Devices

Investigators

Study Director: Jessie Coe, Abbott
Principal Investigator: Ki E Park, MD, University of Florida/Malcom Randall VAMC
Principal Investigator: Chi-Jen Chang, MD, Chang Gung Memorial Hospital