Radial Artery Versus No-touch Vein Graft
Study Details
Study Description
Brief Summary
This study evaluates the short-term and long-term patency of the radial artery and the No-touch vein in patients undergoing isolated on-pump/off-pump coronary artery bypass graft (CABG) surgery. A total of at least 774 patients undergoing isolated on-pump/off-pump CABG will be consecutively recruited from Fuwai Hospital and randomly assigned to receive radial artery or No-touch saphenous vein as their second graft. All participants will be invited for clinical follow-up and 64-slice multislice computed tomography angiography (MSCTA) analysis at 3 months and 12 months post-operatively.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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N/A |
Detailed Description
CABG is still the treatment of choice for ischemic heart disease. However, restenosis or occlusion may occur to graft vessels, leading to postoperative myocardial ischemia and subsequent clinical events. Long-term angiographic follow-up demonstrated that vein graft restenosis and occlusion are common among those receiving CABG, with a vein graft patency of less than 50% at 15 years postoperatively.
A novel approach to harvesting the vein is called "No-touch" technique (NT), which can avoid mechanical damage to the vein wall. Previous studies showed that No-touch saphenous vein grafts (NT-SVG) has a 96.3% postoperative graft patency rate at 12 months, compared to 93.5% of conventional saphenous vein grafts (con-SVGs). Thus, the No-touch technique can significantly reduce postoperative graft occlusion. Radial artery as an arterial material for CABG surgery has a better long-term patency than con-SVG, up to 83% at 10 years. Using radial artery as the second graft for CABG may provide additional clinical benefit. However, the risk of perioperative vasospasm and graft occlusion due to competitive blood flow limit the using of radial artery. Therefore, only the No-touch vein and the radial artery can improve the graft patency. Only one RCT compared the RA and NT-vein, and this study is limited by irregular post-operative management and small sample size from single center.
This prospective single-center study aims to compare the short-term and long-term graft patency between the No-touch vein and the radial artery. This study will consecutively enroll at least 774 patients undergoing isolated on-pump/off-pump CABG. After obtaining informed written consent, participants will be randomly allocated to either the No-touch or the radial artery group. At baseline, participants will be interviewed to collect detailed information about on demographics, socioeconomic status, cardiovascular risk factors, clinical characteristics, treatments, in-hospital outcomes, general and disease-specific quality of life, function and mental status. During the follow-ups, the investigators will collect information about clinical outcomes events, long-term treatments, function, quality of life, symptoms, and medical care during the recovery period. All participants will be invited for 64-slice multi-slice computed tomography angiography (MSCTA) analysis at 3 months and 12 months post-operatively for graft patency evaluation.
The data adjudicators and CT reviewers will be blinded to the study. Due to the nature of this study, the operating surgeons, anesthetists and other operative room staff will not be blind in this study. Owing to the use of radial artery need approved by the participant, so participants will also not be blind in this study,
By comparing the short-term and long-term graft patency between the No-touch vein and radial artery groups, this study will contribute major evidence of the possible superiority between two different grafts, so as to improve patient outcomes after CABG surgery.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: No-Touch vein No-touch vein group has two No-touch saphenous vein grafts, anastomose to the right coronary or left coronary system. All patients also acquired LITA-LAD anastomosis to complete the revascularization. |
Procedure: No-touch vein graft
Two No-touch saphenous vein grafts anastomose to the right coronary and left coronary system. All participants also acquired Left intrathoracic artery(LITA)-left anterior decending artery(LAD) anastomosis to complete the revascularization.
|
| Active Comparator: Radial artery Radial artery group has one radial artery graft and one conventional saphenous vein graft, anastomose to the right coronary or left coronary system basing on surgeons' decision. All patients also acquired LITA-LAD anastomosis to complete the revascularization. |
Procedure: Radial artery graft
One radial artery graft and one conventional saphenous vein graft anastomose to the right coronary or left coronary system basing on surgeons' decision. All participants also acquired Left intrathoracic artery(LITA)-left anterior decending artery(LAD) anastomosis to complete the revascularization.
|
Outcome Measures
Primary Outcome Measures
- Prevalence of graft patency [12 months after procedure]
All participants will be invited to return to their operating hospitals for 64-slice multi-slice computed tomography angiography to determine patencies of the graft vessels.
Secondary Outcome Measures
- Prevalence of graft patency [3 months, 3 years and 5 years after procedure]
All participants will be invited to return to their operating hospitals for 64-slice multi-slice computed tomography angiography to determine patencies of the graft vessels.
- Overall major adverse cardiac or cerebrovascular events (MACCE) rate [3 months, 12 months, 3 years and 5 years after procedure]
MACCE includes death, myocardial infarction, stroke and/or repeat revascularization
- Cardiac death [3 months, 12 months, 3 years and 5 years after procedure]
Death from any heart disease
- Documented non-lethal myocardial infarction [3 months, 12 months, 3 years and 5 years after procedure]
Myocardial infarction is defined according to the most recent guideline
- Stroke [3 months, 12 months, 3 years and 5 years after procedure]
An acute symptomatic episode of focal or global neurological dysfunction caused by brain, spinal, or retinal vascular injury as a result of hemorrhage or infarction
- Target lesion revascularization [3 months, 12 months, 3 years and 5 years after procedure]
CABG or percutaneous coronary intervention
- Recurrence of Angina [3 months, 12 months, 3 years and 5 years after procedure]
Recurrence of Angina
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age more than 18 years old
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First time undergo isolated CABG surgery
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Severe three-vessel disease (LAD, LCX, RCA lesion with more than 75% stenosis)
Exclusion Criteria:
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Urgent or Redo CABG surgery
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Concomitant cardiac or vascular procedures (i.e. valve repair or replacement, Morrow procedure)
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A positive Allen test, radial artery plaque on ultrasound or a history of vasculitis or Raynaud's syndrome
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Varicose great saphenous vein or venous tortuosity and judged as can not be used in operation by surgeons
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Known allergy to radiographic contrast media
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Planed endarterectomy of coronary artery before surgery
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Malignant tumor or other severe systemic diseases
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Combined with other irreversible organ failures
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Contraindications for dual antiplatelet therapy, such as active gastroduodenal ulcer
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Participant of other ongoing clinical trials in 30 days.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Fuwai Hospital Chinese Academay of Medical Science and National Center for Cardiovascular Diseases | Beijing | Beijing | China | 100037 |
Sponsors and Collaborators
- China National Center for Cardiovascular Diseases
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2023-2109