CABG Based on CT-FFR Versus Conventional Coronary Angiography
Study Details
Study Description
Brief Summary
The aims of study are (1) to compare early and 1-year graft patency rates in patients who underwent coronary artery bypass grafting (CABG) based on conventional coronary angiography(CAG) versus cardiac computed tomography(CT)-derived fractional flow reserve(FFR), and (2) to demonstrate difference in clinical outcomes between the 2 groups.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The CABG-COREA trial is designed as a randomized, controlled trial to recruit 80 patients who undergo coronary artery bypass grafting. Patients were randomized by use of a randomization table. Coronary arteries are revascularized based on conventional coronary angiography or cardiac computed tomography-derived fractional flow reserve according to the randomization result.
The primary end point is to evaluate early and 1-year postoperative graft patency. The secondary end points are overall survival, freedom from cardiac death and freedom from MACCE(major adverse cardiac or cerebrovascular events).
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: CAG group Patients who underwent coronary artery bypass grafting based on conventional coronary angiography |
Procedure: Coronary artery bypass grafting based on conventional coronary angiography
Revascularized coronary arteries are decided based on conventional coronary angiography.
|
| Active Comparator: CT-FFR group Patients who underwent coronary artery bypass grafting based on cardiac computed tomography-derived fractional flow reserve |
Procedure: Coronary artery bypass grafting based on cardiac computed tomography-derived fractional flow reserve.
Revascularized coronary arteries are decided based on cardiac computed tomography-derived fractional flow reserve.
|
Outcome Measures
Primary Outcome Measures
- 1-Year graft patency rates [1 year]
postoperative graft patency measured by 1 year postoperative coronary angiography
Secondary Outcome Measures
- Overall survival [4 years]
Overall survival rate at 4 years
- Freedom from Cardiac Death [4 years]
Freedom from cardiac death at 4 years
- Freedom From MACCE(Major Adverse Cardiac and Cerebrovascular Events) [4 years]
freedom from MACCE(major adverse cardiac and cerebrovascular events)at 4 years
- Early Angiographic Patency Rates [1.5 days]
The patency rate of the grafts evaluated with coronary angiograms early after coronary artery bypass grafting
Eligibility Criteria
Criteria
Inclusion Criteria:
-
age equal or more than 40
-
age equal or less than 75
-
patients who undergo coronary artery bypass grafting due to multi-vessel coronary artery disease
-
patients who agree to the enrollment
Exclusion Criteria:
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Patients with heart failure (left ventricular ejection fraction < 25%)
-
patients who have intractable ventricular arrhythmia
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patients who has been treated for cancer
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patients who has infectious disease
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patients who are planned to undergo combined cardiac surgery
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patients who has medical co-morbidity with expected survival less than 1 year
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patients with a history of previous cardiac surgery
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Patients with chronic renal failure requiring dialysis
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patients who undergo emergency operation
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Myongji Hospital
Investigators
- Study Chair: Min-Seok Kim, MD, PhD, MSc, Cardiovascular Center, Myongji Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MyongjiH