Multi Detector-Row Computed Tomography (MDCT) Calcium Score of Heart Transplanted Patients

Sponsor

Oslo University Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT00294853

Collaborator

(none)

240

Enrollment

Location

Duration (Months)

13.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of the study is to determine if calcium score can be used as a predictor of coronary artery disease in heart transplanted patients, as it is used in non-transplanted persons.

Condition or Disease	Intervention/Treatment	Phase
Coronary Artery Disease	Procedure: MDCT calcium score	N/A

Detailed Description

Several studies have shown that a negative calcium score is a strong independent negative predictor of coronary artery disease (CAD). CAD in heart transplants (HTx) differs from CAD lesions in native hearts. The aim of this study is to see if there is a similar relation between coronary artery calcium and CAD in transplanted hearts as in native hearts.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

240 participants

Allocation:

Non-Randomized

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Diagnostic

Official Title:

MDCT Calcium Score of Heart Transplanted Patients

Study Start Date :

Dec 1, 2005

Study Completion Date :

Jun 1, 2007

Outcome Measures

Primary Outcome Measures

Calcium score [at the date of examination]

Secondary Outcome Measures

Coronary stenoses found on coronary angiography [at the date of examination]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Heart transplanted patient
Aged 18 or above.

Exclusion Criteria:

Pregnancy
Atrial fibrillation
Severe heart failure New York Heart Association (NYHA) class IV
Severe pulmonary disease making the patient unable to hold his/her breath for more than 10 seconds.