Vascular Response to Isoproterenol and β2 Adrenergic Receptor Polymorphisms

• Sponsor: Hadassah Medical Organization (Other)
• Overall Status: Completed
• CT.gov ID: NCT00226551
• Collaborator: (none)
• Enrollment: 100
• Location: 1

Study Details

Study Description

Brief Summary

Single nucleotide polymorphisms at codon 46 and 79 of the gene encoding for the ß2 adrenergic receptor (ß2AR) modify its pharmacological properties and may alter the response to ß2AR agonists. The goal of the present study was to evaluate the role played by the Arg16Gly and Gln27Glu polymorphisms on isoproterenol induced relaxation of internal mammary arteries segments ex-vivo.

Internal mammary leftover segments were collected from 96 patients undergoing coronary artery bypass graft operation. Four rings that were prepared from each specimen were allowed to reach equilibrium with physiological Krebs solution prior to precontraction with U46619. Using the organ bath technique, cumulative dose response curve of isoproterenol was constructed and mean EC50 calculated for each patient.

Condition or Disease	Intervention/Treatment	Phase
Coronary Disease	Drug: Isoproterenol	N/A

Study Design

• Study Type: Interventional
• Allocation: Non-Randomized
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Official Title: ß2 Adrenergic Receptor Polymorphisms and Vasodilation of Internal Mammary Artery Induced by Isoproterenol
• Study Start Date: Aug 1, 1999

Outcome Measures

Primary Outcome Measures

1. Mean Ec50% in response to rising concentration of isoproterenol []

Eligibility Criteria

Criteria

• Ages Eligible for Study: 20 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• patients scheduled to undergo coronary artery bypass graft operation

Exclusion Criteria:

• Chronic treatment with corticosteroids

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Hadassah Medical Organization	Jerusalem		Israel

Sponsors and Collaborators

• Hadassah Medical Organization

Investigators

• Principal Investigator: Yoseph Caraco, MD, Hadassah Medical Organization

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT00226551
• Other Study ID Numbers: yc19558-HMO-CTIL
• First Posted: Sep 27, 2005
• Last Update Posted: Oct 29, 2008
• Last Verified: Oct 1, 2008

• Additional relevant MeSH terms: Coronary Disease; Isoproterenol

Study Results

No Results Posted as of Oct 29, 2008