Half-Dose Intracoronary Abciximab Bolus Improves the Mortality Outcome Compared to Standard Intravenous Regimen
Study Details
Study Description
Brief Summary
The aim of our study was to demonstrate that, during a percutaneous coronary intervention, even smaller amounts of abciximab than standard dose, injected locally, could achieve a rapid thrombus resolution and clinical improvement without concomitant differences in hemorrhagic complications
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
Phase 4 |
Detailed Description
Patients both with acute myocardial infarction and unstable angina are prone to extensive intracoronary thrombosis, leading to acute deterioration during percutaneous coronary intervention or thrombosis of the device despite therapy. Intracoronary use of abciximab has reported favourable results. We randomly assigned 84 patients to intracoronary half abciximab bolus (group A) and to standard regimen (group B).
Study Design
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Inclusion Criteria:
-
presenting with unstable angina
-
presenting with acute myocardial infarction
-
eligibility for percutaneous coronary intervention
Exclusion Criteria:
- presenting with cardiogenic shock
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Cardiologia 2 - Emodinamica - Ospedale Maggiore | Novara | Italy | 28100 |
Sponsors and Collaborators
- Azienda Sanitaria Ospedaliera
- Cardiologia 2 - Emodinamica - Ospedale Maggiore, Novara, Italy
Investigators
- Principal Investigator: Mara Sansa, Chief Interventional Cardiology - Ospedale Maggiore - Novara - Italy
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- ABCX-LD