Formulation and Efficacy of Exercise Prescription for Patients With Coronary Heart Disease
Study Details
Study Description
Brief Summary
The purposes of this study is to standardize the process of formulating exercise prescriptions for coronary heart disease（CHD）, verify the safety and effectiveness of exercise prescriptions, and establish a database of exercise prescriptions for CHD, with a view to providing new solutions for cardiac rehabilitation.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
This study conducted a comparative study on the therapeutic effect and safety of exercise prescriptions for patients with coronary heart disease with different risk stratifications. The purposes of this study is to standardize the process of formulating exercise prescriptions for coronary heart disease（CHD）, verify the safety and effectiveness of exercise prescriptions, and establish a database of exercise prescriptions for CHD, with a view to providing new solutions for cardiac rehabilitation.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Moderate Intensity Group Group received a moderate exercise prescription of moderate intensity |
Behavioral: Moderate intensity exercise prescription
Exercise Intensity： Low-risk patients: the lower of 60-69% reserve heart rate or the heart rate at the anaerobic threshold.
Moderate-risk or high-risk patients: the lower of 50-59% reserve heart rate or the heart rate at the anaerobic threshold.
|
| Experimental: High Intensity Group Group received a moderate exercise prescription of high intensity |
Behavioral: High intensity exercise prescription
Exercise Intensity： Low-risk patients: the lower of 70-85% reserve heart rate or the heart rate at the anaerobic threshold.
Moderate-risk or high-risk patients: the lower of 60-70% reserve heart rate or the heart rate at the anaerobic threshold.
|
Outcome Measures
Primary Outcome Measures
- Incidence of MACE [6 month]
any incidence of the following: death, cardiac death, AMI, revascularization, stroke
- The score of Seattle Angina Questionnaire increased [6 month]
The score of Seattle Angina Questionnaire (SAQ, 0-100 each dimension, higher means greater condition）increased.
- Routine color Doppler echocardiography changed. [6 month]
Routine color Doppler echocardiography changed.
- Improvement of Cardiopulmonary exercise test [6 month]
the improvement of maximum oxygen uptake
- Improvement of 6-minute walk test [6 month]
the improvement of 6 minute walking distance
- Improvement of grip strength test [6 month]
the improvement of grip strength
Secondary Outcome Measures
- The score of Medical Outcomes Study Questionnaire Short Form 36 Health Survey (36-Item Short Form Survey) increased [6 month]
The score of Medical Outcomes Study Questionnaire Short Form 36 Health Survey (abbreviation form is 36-Item Short Form Survey) increased. The SF-36 has eight scaled scores; the scores are weighted sums of the questions in each section. Scores range from 0 - 100 Lower scores = more disability, higher scores = less disability, The sections consists of Vitality, Physical functioning, Bodily pain, General health perceptions, Physical role functioning, Emotional role functioning, Social role functioning, and Mental health. The total score of SF 36 Health survey is higher, the quality of life is higher.
- The score of Patient Health Questionnaire decreased [6 month]
The score of patient health questionnaire (PHQ9, normal range 0-27，indicating the profile of depression with the higher score) decreased
- The score of Generalized Anxiexy Disorde-7 decreased [6 month]
The score of Generalized Anxiexy Disorde-7 (GAD7, normal range 0-21，indicating the profile of anxiety with the higher score) decreased
- The score of Chinese perceived stress scale decreased. [6 month]
The score of Chinese perceived stress scale (CPSS, 0-56, higher means more stress) decreased.
- The score of Pittsburgh Sleep Quality Index Scale decreased. [6 month]
The score of Pittsburgh Sleep Quality Index Scale (PSQI, 0-21, higher means poorer sleep quality）decreased.
- The score of Fagerstrom Test for Nicotine Dependence decreased. [6 month]
The score of Fagerstrom Test for Nicotine Dependence (FTND, 0-10, higher means more dependence on nicotine）decreased.
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patients aged 18-80 years old with a diagnosis of coronary heart disease，NYHA class I-III HF patients.
Exclusion Criteria:
-
acute myocardial infarction within 2 weeks
-
Uncontrolled tachycardia (heart rate at rest >120bpm
-
Uncontrolled polypnea（breath rate at rest >30 breath per minute
-
Uncontrolled respiratory failure （SPO2 ≤90%）
-
Uncontrolled hyperglycemia (Random blood glucose>18mmol/L)
-
Uncontrolled malignant arrhythmia with hemodynamic instability
-
Uncontrolled septic shock and septicopyemia
-
Uncooperation of the patients
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Chinese PLA General Hospital | Beijing | China |
Sponsors and Collaborators
- Jing Ma
Investigators
- Principal Investigator: Jing Ma, Department of Cardiology in Chinese PLA General Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2021-249