Human Vasodilatory Effect of GLP-1
Sponsor
Papworth Hospital NHS Foundation Trust (Other)
Overall Status
Completed
CT.gov ID
NCT03502083
Collaborator
(none)
11
15
Study Details
Study Description
Brief Summary
Comprehensive assessment of human vasodilatory effect of GLP-1 in forearm and coronary arteries
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Study Type:
Interventional
Actual Enrollment
:
11 participants
Allocation:
Non-Randomized
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Basic Science
Official Title:
Vasodilatory Effect of GLP-1
Actual Study Start Date
:
Dec 1, 2015
Actual Primary Completion Date
:
Mar 1, 2017
Actual Study Completion Date
:
Mar 1, 2017
Outcome Measures
Primary Outcome Measures
- Change in IMR (index of microcirculatory resistance) with GLP-1 compared with baseline [Change from baseline]
Change in coronary microcirculatory resistance from baseline
- Forearm bloodflow ratio with GLP-1 [Change from baseline]
Peripheral vasodilatory response of GLP-1
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
- Waiting list for elective PCI to LAD Able to give informed consent Over 18
Exclusion Criteria:
- GLP-1 based therapy Insulin Calcium channel blockers Nicorandil Nitrates
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Papworth Hospital NHS Foundation Trust
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Papworth Hospital NHS Foundation Trust
ClinicalTrials.gov Identifier:
NCT03502083
Other Study ID Numbers:
- 14/EE/0018
First Posted:
Apr 18, 2018
Last Update Posted:
Apr 18, 2018
Last Verified:
Apr 1, 2018
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms: