Correlation Between the Changes of Retinal Structure and Function and Ischemic Stroke

Sponsor

Guangdong Provincial People's Hospital (Other)

Overall Status

Recruiting

CT.gov ID

NCT05281887

Collaborator

(none)

120

Enrollment

Location

121

Anticipated Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Ischemic stroke is the most common type of stroke, accounting for 60%-80% of all types of strokes, and is one of the leading global causes of death and severe disability. In the risk factors of stroke, carotid atherosclerosis have higher incidence.As the only visible microvessels in vivo, retinal can provides an accurate window into cerebrovascular and systemic vascular conditions. Optical coherence tomography angiography (OCTA) and electroretinogram (ERG) can be used to quantitatively analyze the retinal structure and function in patients with ischemic stroke, and find out the valuable parameters. Electroencephalogram(EEG) can collect the electrical activity of cerebral cortex in patients with ischemic stroke and find the correlation between EEG and ERG. Finally, it is of great significance to establish a non-invasive, more objective, convenient and safe risk prediction model for stroke in combination with carotid atherosclerosis, retinal structural and functional parameters and EEG.

Condition or Disease	Intervention/Treatment	Phase
Ischemic Stroke

Detailed Description

Firstly, this study will cross sectional analyze the retinal structure and function of patients with ischemic stroke to find the closely related parameters. Secondly, based on the results of cross section analysis, a cohort study will be established to build a risk prediction model for stroke combining carotid atherosclerosis, retinal structure and function parameters and EEG.

Study Design

Study Type:

Observational

Anticipated Enrollment :

120 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Correlation Between the Changes of Retinal Structure and Function and Ischemic Stroke

Actual Study Start Date :

Dec 1, 2021

Anticipated Primary Completion Date :

Dec 31, 2022

Anticipated Study Completion Date :

Jan 1, 2032

Arms and Interventions

Arm	Intervention/Treatment
ischemic stroke According to diagnostic criteria
healthy control without any retinal diseases

Outcome Measures

Primary Outcome Measures

Optical coherence tomography angiography (OCTA) [1year]
Quantitatively analyzing the retinal microcirculation and structure in patients with ischemic stroke by using OCTA.
Electroretinogram (ERG) [1year]
The amplitude(μV) and implicit time(ms) of a-wave, b-wave and oscillatory potentials in dark-adapted and light-adapted.

Other Outcome Measures

Electroencephalogram(EEG) [1year]
Collecting the electrical activity of cerebral cortex in patients with ischemic stroke, including the electroencephalogram frequency(Hz) and amplitude(μV) of δ-wave, θ-wave, α-wave and β-wave. In addition, the pattern of these waves will be observed to find the signatures of ischemic stroke.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Patients with ischemic stroke

Exclusion Criteria:

Refractive interstitial turbidity affect the examination results
Any retinal diseases
Other causes of ischemic stroke (cardiogenic embolism, dissection aneurysm, hemagglutination disorder, polycythemia, vasculitis, vascular malformation, etc.)
Fails to complete an ophthalmic examination or the follow-up