Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) (18FDG-PET)

• Sponsor: Korea University (Other)
• Overall Status: Completed
• CT.gov ID: NCT01150019
• Collaborator: (none)
• Enrollment: 120
• Location: 1
• Duration (Months): 2
• Patients Per Site Per Month: 59.9

Study Details

Study Description

Brief Summary

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis.Resistin was shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between circulating resistin and vascular inflammation detected by 18FDG-PET in obese persons.

Condition or Disease	Intervention/Treatment	Phase
Atherosclerosis	Other: Cross sectional study

Study Design

• Study Type: Observational
• Actual Enrollment: 120 participants
• Observational Model: Case-Control
• Time Perspective: Cross-Sectional
• Official Title: Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18FDG-PET in Obese Person
• Study Start Date: Apr 1, 2010
• Actual Primary Completion Date: Jun 1, 2010
• Actual Study Completion Date: Jun 1, 2010

Arms and Interventions

Arm	Intervention/Treatment
Obese Group	Other: Cross sectional study; This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting
Non Obese Group	Other: Cross sectional study; This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting

Outcome Measures

Primary Outcome Measures

1. Vascular inflammation in carotid arterial wall represented as the target-to-background ratio (TBR) using FDG-PET [12 weeks]

Secondary Outcome Measures

1. Circulating serum adiponectin levels [12 weeks]

2. carotid intima-media thickness levels measured using ultrasonography [12 weeks]

3. Circulating serum resistin levels [12 weeks]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 20 Years to 80 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Healthy volunteers for visiting routine medical check in our clinic

Exclusion Criteria:

• History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)

• Diabetes

• Hypertension

• Malignancy

• Severe renal or hepatic disease

• Subjects taking medications that might affect inflammation such as non-steroidal anti-inflammatory drugs (NSAIDs) and statin

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Hae Yoon Choi	Seoul		Korea, Republic of	152-703

Sponsors and Collaborators

• Korea University

Investigators

• Principal Investigator: Kyung Mook Choi, MD.PhD, Korea University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT01150019
• Other Study ID Numbers: PET_Resistin
• First Posted: Jun 24, 2010
• Last Update Posted: Jul 8, 2010
• Last Verified: Apr 1, 2010

• Keywords provided by , ,: atherosclerosis; vascular inflammation; resistin; adiponectin; 18FDG-PET
• Additional relevant MeSH terms: Atherosclerosis; Inflammation

Study Results

No Results Posted as of Jul 8, 2010