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Correlation Between NAFLD, Epicardial Adipose Tissue and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)

Sponsor
Korea University (Other)
Overall Status
Completed
CT.gov ID
NCT01958411
Collaborator
(none)
340
Enrollment
1
Location

Study Details

Study Description

Brief Summary

  • Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.

  • Non-alcoholic fatty liver disease (NAFLD) is closely associated with many cardiometabolic risk factors. NAFLD can be detected by measuring liver fat accumulation using computed tomography (CT).

  • Also epicardial adipose tissue (EAT) volume as determined by computed tomography (CT) is an independent marker of cardiovascular events in the general population.

  • Therefore, the purpose of this investigators study is to compare the NAFLD severity and EAT volume with FDG uptake measured by PET/CT.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    340 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Cross-Sectional
    Study Start Date :
    Dec 1, 2008
    Actual Primary Completion Date :
    Mar 1, 2011

    Arms and Interventions

    Arm Intervention/Treatment
    18FDG-PET/CT

    Outcome Measures

    Primary Outcome Measures

    1. Correlation between vascular inflammatory status measured by 18FDG PET and NAFLD measured by un-enhanced CT [12 weeks]

    2. Correlation between vascular inflammatory status measured by 18FDG PET and epicardial adipose tissue measured by CT [12 weeks]

    Secondary Outcome Measures

    1. The relationship of NAFLD with carotid intima media thickness [12 weeks]

    2. The relationship of epicardial adipose tissue volume with carotid intima media thickness [12 weeks]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years to 80 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • Healthy patients for visiting routine medical check in our clinic
    Exclusion Criteria:

    • History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)

    • Diabetes

    • Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg)

    • Malignancy

    • Severe renal or hepatic disease

    • Subjects taking medications that might affect inflammation such as nonsteroidal antiinflammatory drug and statin

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Korea University Guro Hospital Seoul Korea, Republic of

    Sponsors and Collaborators

    • Korea University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    K. M. Choi, Professor, Korea University
    ClinicalTrials.gov Identifier:
    NCT01958411
    Other Study ID Numbers:
    • PET(NAFLD, EAT)
    First Posted:
    Oct 9, 2013
    Last Update Posted:
    Oct 9, 2013
    Last Verified:
    Oct 1, 2013
    Additional relevant MeSH terms:
    Liver Diseases
    Fatty Liver
    Non-alcoholic Fatty Liver Disease
    Atherosclerosis

    Study Results

    No Results Posted as of Oct 9, 2013