Correlation Between Various Inflammatory Markers and Vascular Inflammation Measured by 18FDG-PET

• Sponsor: Korea University (Other)
• Overall Status: Completed
• CT.gov ID: NCT01022684
• Collaborator: (none)
• Enrollment: 150
• Location: 1
• Duration (Months): 1
• Patients Per Site Per Month: 147.3

Study Details

Study Description

Brief Summary

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. Various inflammatory markers such as LpPLA2,MCP-2 and hsCRP are well-known prognostic factors for the cardiovascular event.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between various inflammatory markers and vascular inflammation detected by 18FDG-PET.

Condition or Disease	Intervention/Treatment	Phase
Atherosclerosis	Other: Cross section study

Study Design

• Study Type: Observational
• Actual Enrollment: 150 participants
• Observational Model: Cohort
• Time Perspective: Cross-Sectional
• Official Title: Correlation of Inflammatory Markers Such as LpPLA2,MCP-1 and hsCRP for Predicting Vascular Inflammation; Analysis With 18F-Fluorodeoxyglucose Positron Emission Tomography
• Study Start Date: Dec 1, 2009
• Actual Primary Completion Date: Jan 1, 2010
• Actual Study Completion Date: Jan 1, 2010

Arms and Interventions

Arm	Intervention/Treatment
Healthy patients	Other: Cross section study; This is not intervention study. The purpose of the study is to examine the relationship between various inflammatory markers and PET imaging at the cross section setting

Outcome Measures

Primary Outcome Measures

1. Correlation between various inflammatory markers including LpPLA2,MCP-1 and hsCRP and vascular inflammation analyzed by 18FDG-PET [12 weeks]

Secondary Outcome Measures

1. Correlation between various inflammatory markers and atherosclerosis measured by carotid intima media thickness [12 weeks]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 20 Years to 88 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Healthy patients for visiting routine medical check in our clinic

Exclusion Criteria:

• History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)

• Diabetes

• Stage 2 hypertension (resting blood pressure, ≥160/100 mmHg)

• Malignancy

• Severe renal or hepatic disease

• Subjects taking medications that might affect inflammation such as NSIAD and statin

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Hye Jin Yoo	Seoul		Korea, Republic of

Sponsors and Collaborators

• Korea University

Investigators

• Principal Investigator: Kyung Mook Choi, MD.PhD, Korea University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT01022684
• Other Study ID Numbers: KOSEF20546
• First Posted: Dec 1, 2009
• Last Update Posted: Feb 22, 2010
• Last Verified: Nov 1, 2009

• Keywords provided by , ,: atherosclerosis; vascular inflammation; LpPLA2; hsCRP; MCP-1; 18FDG-PET
• Additional relevant MeSH terms: Atherosclerosis; Inflammation

Study Results

No Results Posted as of Feb 22, 2010