Correlation of Biochemical Indexes and Retinal Hemodynamic in Patients With Different Degrees of Diabetic Retinopathy
Study Details
Study Description
Brief Summary
All OCTA data and biochemical indexes of diabetic patients were acquired. A prediction model of diabetic retinopathy was built, and the random forest method was used to identify sensitive indicators.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Detailed Description
Diabetic patients at the Department of Ophthalmology of the Seventh Affiliated Hospital of Sun Yat-sen University were selected as research participants. All OCTA data and biochemical indexes were acquired. A prediction model of diabetic retinopathy was built, and the random forest method was used to identify sensitive indicators.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Group 1 diabetic patients with no diabetic retinopathy |
Diagnostic Test: imaging
imaging
|
Group 2 diabetic patients with mild nonproliferative diabetic retinopathy |
Diagnostic Test: imaging
imaging
|
Group 3 diabetic patients with moderate and severe nonproliferative diabetic retinopathy |
Diagnostic Test: imaging
imaging
|
Group 4 diabetic patients with proliferative diabetic retinopathy |
Diagnostic Test: imaging
imaging
|
Outcome Measures
Primary Outcome Measures
- fasting blood glucose (FBG) [the time of the patient's first 1 day visit]
biochemical indexes
- glycosylated hemoglobin (HbAlc) [the time of the patient's first 1 day visit]
biochemical indexes
- OCTA data [the time of the patient's first 1 day visit]
An image of the 3mm×3mm and 6 mm×6 mm macular areas detected by OCTA were captured. Quantitative analysis of vascular density and perfusion density of superficial capillary plexus in the macular area were automatically calculated using built-in software on the device.
Eligibility Criteria
Criteria
Inclusion Criteria:
- Clinical diagnosis of diabetes
Exclusion Criteria:
-
various other types of retinal and choroidal disease;
-
history of any intraocular surgery or treatment (including intravitreal injection, retinal photocoagulation etc.
-
with severe refractive medium opacity that could affect fundus examination.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | The Seventh Affiliated Hospital, Sun Yat-sen University | Shenzhen | Guangdong | China | 518000 |
Sponsors and Collaborators
- Mingzhe Cao
Investigators
- Principal Investigator: Mingzhe Cao, The Seventh Affiliated Hospital of Sun Yat-sen University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MCao