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Correlation of Lung Biopsy, BAL, and High Resolution CT Scan in Lung Transplantation

Sponsor
University of Chicago (Other)
Overall Status
Completed
CT.gov ID
NCT00528853
Collaborator
(none)
10
Enrollment
1
Location
28
Duration (Months)
0.4
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

A major source of graft failure and dysfunction in lung transplantation is known to be bronchiolitis obliterans (BO)and its clinical correlate called bronchiolitis obliterans syndrome(BOS). In fact, BOS is the leading cause of death in lung recipients beyond one year post transplant. Currently, our ability to assess lung injury after transplant is less than ideal.

The purpose of this study is to use new computerized tomography(CT) technology, specifically , 64 bit acquisition, to detect and predict the onset of lung injuries, with the hope of finding better therapies that currently exist.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Total enrollment : 10

    Lung transplant patients will undergo CT Scans before scheduled bronchoscopies which are routinely performed at 1, 3, 6, 9, and 12 months post transplant. Imaging will be done with the newest generation scanner, with intent to analyze all pertinent areas of the lung for pathology, but especially the bronchial anastomoses, the lung parenchyma with focus on gas exchanging lobules of the lung, and any suspected abnormalities from physical exam, laboratory tests, or prior chest xray.

    CT imaging will precede bronchoscopy and biopsy so that CT interpretation will be unencumbered by changes due to the bronchoscopic procedure.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    10 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Prospective
    Official Title:
    Correlation of Lung Biopsy, BAL, and High Resolution CT Scan in Lung Transplantation. Can We Help Diagnose Acute Rejection and Better Predict Bronchiolitis Obliterans?
    Study Start Date :
    Aug 1, 2007
    Actual Primary Completion Date :
    Dec 1, 2009
    Actual Study Completion Date :
    Dec 1, 2009

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years to 65 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:

      • Lung transplant patients who are at least 18 years of age.

      • All patients must be able to give written informed consent.

      Exclusion Criteria:

      • Lung transplant patients who are unable to undergo a CT Scan.

      • Lung transplant patients who are unable to give informed consent.

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 The University of Chicago Medical Center Chicago Illinois United States 60637

      Sponsors and Collaborators

      • University of Chicago

      Investigators

      • Principal Investigator: Edward Garrity, MD, University of Chicago

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      University of Chicago
      ClinicalTrials.gov Identifier:
      NCT00528853
      Other Study ID Numbers:
      • 15660A
      First Posted:
      Sep 12, 2007
      Last Update Posted:
      Aug 19, 2016
      Last Verified:
      Aug 1, 2016
      Keywords provided by University of Chicago
      Bronchiolitis Obliterans Syndrome
      Additional relevant MeSH terms:
      Bronchiolitis
      Bronchiolitis Obliterans

      Study Results

      No Results Posted as of Aug 19, 2016