COVOICE: COVID-19: Early Detection of Worsening by Voice and Respiratory Pattern Characteristics
Study Details
Study Description
Brief Summary
In some clinical forms of COVID-19, an uncontrolled hyper-inflammatory reaction known as a "cytokine storm" appears abruptly, around day 7, and is associated with rapid respiratory deterioration, requiring hospitalization in an intensive care unit (ICU).
At present, although risk factors for this severe form have been described, there are no validated criteria for determining which individual patients will develop this aggravation.
The study of respiratory sounds (amplitude, frequency, ...) has made it possible in other respiratory pathologies (e.g., chronic obstructive pulmonary disease) to predict exacerbations several days in advance.
Having a predictive respiratory pattern for worsening in COVID-19 would make it possible to anticipate the need for intensive care hospital beds, by means of a tool easily available on a mobile phone.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| COVID
|
Device: COVOICE application use - follow-up
Daily recording of sound related to respiratory movements, coughing and voice using a mobile phone application. Duration: up to 30 days
|
| Other respiratory diseases
|
Device: COVOICE application use - follow-up
Daily recording of sound related to respiratory movements, coughing and voice using a mobile phone application. Duration: up to 30 days
|
| Healthy
|
Device: COVOICE application use - initial
Recording (only once) of sound related to respiratory movements, coughing and voice using a mobile phone application
|
Outcome Measures
Primary Outcome Measures
- Sensitivity of the respiratory pattern demonstrated in the COVID patients who experienced respiratory worsening [Through study completion (36 months)]
- Specificity of the respiratory pattern demonstrated in the COVID patients who experienced respiratory worsening [Through study completion (36 months)]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
French speaking
-
Affiliated to a social security system
-
Owning a mobile phone capable of accessing the COVOICE application
Exclusion Criteria:
-
Incapable adults
-
People deprived of their liberty
-
People under administrative or judicial supervision
-
Patients intubated or hospitalized in intensive care unit
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hôpital d'Instruction des Armées Bégin | Saint-Mandé | France | 94160 |
Sponsors and Collaborators
- Direction Centrale du Service de Santé des Armées
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2020-COVID19-21
- 2020-A03182-37