Comparison of COVID-19 and H1N1 Influenza Pneumonia

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University (Other)

Overall Status

Completed

CT.gov ID

NCT04933994

Collaborator

Yueqing People's Hospital of Zhejiang Province (Other), Taizhou Hospital of Zhejiang Province (Other), Ruian People's Hospital of Zhejiang Province (Other), The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University (Other), The First Hospital of Jiaxing, Zhejiang Province (Other), Kecheng People's Hospital of Quzhou city, Zhejiang Province (Other), Pingyang People's Hospital of Zhejiang Province (Other), The First People's Hospital of Yuhang District, Hangzhou, Zhejiang Province (Other)

483

Enrollment

44.5

Actual Duration (Months)

Study Details

Study Description

Brief Summary

To explore the different clinical and CT features distinguishing COVID-19 from H1N1 influenza pneumonia.

Condition or Disease	Intervention/Treatment	Phase
COVID-19 H1N1 Influenza	Device: computed Tomography

Detailed Description

COVID-19 pneumonia patients showed less proportions of underlying diseases, fever and respiratory symptoms than those of H1N1 pneumonia patients (p<0.01). White blood cell count, neutrophilic granulocyte percentage, C-reactive protein, procalcitonin, D-Dimer and lactate dehydrogenase in H1N1 pneumonia patients were higher than those of COVID-19 pneumonia patients (p<0.05). H1N1 pneumonia were often symmetrically located in the dorsal part of lung inferior lobes, while COVID-19 pneumonia were unsually showed a peripheral but non-specific lobe distributions. Ground glass opacity was more common in COVID-19 pneumonia and consolidation lesions was more common in H1N1 pneumonia (p<0.01). COVID-19 pneumonia lesions showed a relative clear margin compared with H1N1 pneumonia. Crazy-paving pattern, thickening vessels, reversed halo sign and early fibrotic leisions were more common in COVID-19 pneumonia than H1N1 pneumonia (p<0.05). Pleural effusion in COVID-19 pneumonia was significantly less common than H1N1 pneumonia (p<0.01).

Compared with H1N1 pneumonia in Zhejiang, China, the clinical manifestations of COVID-19 pneumonia was more concealed with less underlying diseases and slighter respiratory symptoms. The more common CT manifestations of COVID-19 pneumonia included ground glass opacity with a relative clear margin, crazy-paving pattern, thickening vessels, reversed halo sign and early fibrotic leisions, while the less common CT manifestations of COVID-19 pneumonia included consolidation and pleural effusion.

Study Design

Study Type:

Observational [Patient Registry]

Actual Enrollment :

483 participants

Observational Model:

Cohort

Time Perspective:

Other

Official Title:

Comparison of the Clinical and CT Features Between COVID-19 Pneumonia and H1N1 Influenza Pneumonia in Zhejiang, China

Actual Study Start Date :

Jan 1, 2017

Actual Primary Completion Date :

Feb 28, 2020

Actual Study Completion Date :

Sep 15, 2020

Arms and Interventions

Arm	Intervention/Treatment
Coronavirus disease; Influenza A(H1N1) two independent cohorts of COVID-19 pneumonia (n=405) and H1N1 influenza pneumonia (n=78) retrospectively, all patients were confirmed by RT-PCR. Four hundred and five cases of COVID-19 pneumonia were confirmed in nine hospitals of Zhejiang province, China from January 21 to February 20, 2020. Seventy-eight cases of H1N1 influenza pneumonia were confirmed in our hospital from January 1, 2017 to February 29, 2020.	Device: computed Tomography All cases were detected with computed Tomography

Arm

Intervention/Treatment

Coronavirus disease; Influenza A(H1N1)

two independent cohorts of COVID-19 pneumonia (n=405) and H1N1 influenza pneumonia (n=78) retrospectively, all patients were confirmed by RT-PCR. Four hundred and five cases of COVID-19 pneumonia were confirmed in nine hospitals of Zhejiang province, China from January 21 to February 20, 2020. Seventy-eight cases of H1N1 influenza pneumonia were confirmed in our hospital from January 1, 2017 to February 29, 2020.

Device: computed Tomography

All cases were detected with computed Tomography

Outcome Measures

Primary Outcome Measures

Comparison of the clinical and CT features between COVID-19 pneumonia and H1N1 influenza pneumonia in Zhejiang, China [1 year]
one paper

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 80 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

pneumonia

Exclusion Criteria:

no pneumonia

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

Second Affiliated Hospital, School of Medicine, Zhejiang University
Yueqing People's Hospital of Zhejiang Province
Taizhou Hospital of Zhejiang Province
Ruian People's Hospital of Zhejiang Province
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
The First Hospital of Jiaxing, Zhejiang Province
Kecheng People's Hospital of Quzhou city, Zhejiang Province
Pingyang People's Hospital of Zhejiang Province
The First People's Hospital of Yuhang District, Hangzhou, Zhejiang Province

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Second Affiliated Hospital, School of Medicine, Zhejiang University

ClinicalTrials.gov Identifier:

NCT04933994

Other Study ID Numbers:

2021-0187

First Posted:

Jun 22, 2021

Last Update Posted:

Jul 16, 2021

Last Verified:

Oct 1, 2020

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Yes

Product Manufactured in and Exported from the U.S.:

Keywords provided by Second Affiliated Hospital, School of Medicine, Zhejiang University

COVID-19, H1N1, Tomography, X-ray computed

Additional relevant MeSH terms:

COVID-19

Influenza, Human

Pneumonia

Study Results

No Results Posted as of Jul 16, 2021