NSpectroCovid: Study of Morphological, Spectral and Metabolic Manifestations of Neurological Complications in Covid-19 Patients

Sponsor

Centre Hospitalier Universitaire, Amiens (Other)

Overall Status

Active, not recruiting

CT.gov ID

NCT04546737

Collaborator

(none)

Enrollment

Location

19.7

Anticipated Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Viral pandemics, such as HIV and SARS-Cov-V1, have shown that they can lead to acute and / or delayed neurological complications. At the actual context of the pandemic Coronavirus disease 2019 (COVID-19), neurological manifestations seem to be confirmed since in 85% of COVID-19 patients, present neurological symptoms, including anosmia, ageusia, periorbital pain, dizziness, fatigue, even moderate headache, moderate memory and/or behavioral disorders.

However, these neurological manifestations are not well studied and their radiological features are not well described. It is therefore important to assess these potential neurological complications in COVID-19 patients. To the investigator knowledge, there is no previous study in the literature describing spectral brain changes in COVID + patients. Thus, the goal of this work is to describe the radiological semiology using MRI and particularly Magnetic Resonance Spectroscopic (MRS) biomarkers in the evaluation of acute and / or delayed brain damage in COVID + patients presenting a neurological manifestations that are initially related to the cranial nerves damage.

Condition or Disease	Intervention/Treatment	Phase
Covid19 Neurological Manifestations Brain Damage	Other: Magnetic Resonance Spectroscopy (MRS).	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

20 participants

Allocation:

Non-Randomized

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Other

Official Title:

Study of Morphological, Spectral and Metabolic Manifestations of Neurological Complications in Covid-19 Patients

Actual Study Start Date :

Sep 8, 2020

Actual Primary Completion Date :

Jul 1, 2021

Anticipated Study Completion Date :

May 1, 2022

Outcome Measures

Primary Outcome Measures

Variation from baseline of MRI radiological semiology in COVID-19 patients [9 months after patient inclusion]
The radiological semiology as described by MRI and particularly Magnetic Resonance Spectroscopic (MRS) biomarkers in the COVID-19 patients presenting neurological manifestations related initially to the cranial nerves damage.