THERMO-CROHN: Assessment of Intestinal Inflammation by Infrared Thermography in Pediatric Crohn Disease

Centre Hospitalier Universitaire, Amiens (Other)
Overall Status
Recruiting ID

Study Details

Study Description

Brief Summary

The assessment of digestive inflammation and disease activity in paediatrics Crohn's disease (CD) is currently based on anamnestic, clinical and paraclinical elements such as the paediatric CD activity index (wPCDAI) , faecal calprotectin measuring or digestive endoscopy. Infrared thermal imaging is based on capturing electromagnetic waves, on a specific Wavelength, emitted by the human body surface and representing local thermic-metabolic activity. It concern metabolic activity in digestive inflammations. Infrared imaging is a non-invasive, contactless, stressless technique that assess the variations in skin surface temperature of the patient's entire abdomen or more targeted areas in a single photography. This technique would be useful for determination of Crohn's disease activity, inflammation's degree and partial mapping of inflammatory lesions.

In a specific room with a patient lying, the investigators will determine the abdominal infrared radiation with a FLIR® thermal camera. This will be correlated with the measurement of the faecal calprotectin concentration and the composite CD activity index wPCDAI.

All measurements will be performed during the standard follow-up of Crohn disease. No additional follow will be necessary.

Condition or Disease Intervention/Treatment Phase
  • Other: abdominal infrared radiation

Study Design

Study Type:
Anticipated Enrollment :
43 participants
Intervention Model:
Single Group Assignment
Single (Participant)
Primary Purpose:
Official Title:
Assessment of Intestinal Inflammation by Infrared Thermography in Pediatric Crohn Disease
Actual Study Start Date :
Jan 24, 2023
Anticipated Primary Completion Date :
Jan 1, 2024
Anticipated Study Completion Date :
Jan 1, 2024

Outcome Measures

Primary Outcome Measures

  1. correlation between the quantification of abdominal infrared radiation and faecal calprotectin concentration [one year]

    correlation between the quantification of abdominal infrared radiation determined by the FLIR® thermal camera and quantified by the spectral analysis of the thermal signal (in degrees Celsius) and the determination of faecal calprotectin concentration (µg/g of faeces). This concentration will be determined by ELISA method at Biochemistry in Amiens Picardie Faculty hospital.

Eligibility Criteria


Ages Eligible for Study:
4 Years to 17 Years
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Inclusion Criteria:
  • Patients diagnosed with CD according to the Porto criteria [6]

  • Aged from 4 years to 17 years-old

  • Follow-up at the Amiens Picardie University Hospital (CHU Amiens Picardie)

  • Child's affirmative agreement and assent and permission of their parents to participate in research

Exclusion Criteria:
  • Recent abdominal surgery

  • Other Inflammatory bowel disease

Contacts and Locations


Site City State Country Postal Code
1 CHU Amiens Amiens France 80054

Sponsors and Collaborators

  • Centre Hospitalier Universitaire, Amiens


None specified.

Study Documents (Full-Text)

None provided.

More Information


None provided.
Responsible Party:
Centre Hospitalier Universitaire, Amiens Identifier:
Other Study ID Numbers:
  • PI2022_843_0001
First Posted:
Feb 2, 2023
Last Update Posted:
Feb 6, 2023
Last Verified:
Jan 1, 2023
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD:
Studies a U.S. FDA-regulated Drug Product:
Studies a U.S. FDA-regulated Device Product:
Keywords provided by Centre Hospitalier Universitaire, Amiens
Additional relevant MeSH terms:

Study Results

No Results Posted as of Feb 6, 2023