BERGAMOT: A Study to Assess Whether Etrolizumab is a Safe and Efficacious Treatment for Participants With Moderately to Severely Active Crohn's Disease
Study Details
Study Description
Brief Summary
This is a multicenter, Phase 3, double-blind, placebo-controlled study evaluating the efficacy, safety, and tolerability of etrolizumab compared with placebo during induction and maintenance treatment of moderately to severely active Crohn's Disease (CD). The target population includes participants with CD who are refractory or intolerant to corticosteroids (CS) and/or immunosuppressant (IS) therapy and who have either not received prior anti-tumor necrosis factor (anti-TNF) therapy (TNF-naive) or who have had prior exposure to anti-TNF therapies and demonstrated inadequate responses or intolerance to anti-TNFs.
The study period will consist of a Screening Phase (up to 35 days) plus (+) a 14-week Induction Phase + a 52-week Maintenance Phase + a 12-week Safety Follow-up Phase. At Week 14 (end of Induction Phase), participants achieving a decrease from baseline of at least 70 points in the Crohn's Disease Activity Index (CDAI) score (CDAI-70 response) without the use of rescue therapy will continue to the Maintenance Phase.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Induction Phase - Cohort 1 (Exploratory): Etrolizumab 210 mg Cohort 1 enrolled participants first before Cohorts 2 and 3 in order to conduct an exploratory analysis on induction data. Participants randomized to this arm will receive one subcutaneous (SC) injection of etrolizumab (210 mg) at Weeks 0, 2, 4, 8, and 12 during the 14-week Induction Phase. In order to preserve the masking, participants will also receive one SC injection of etrolizumab-matching placebo at Weeks 0, 4, 8, and 12. |
Drug: Etrolizumab
Etrolizumab will be administered as per regimen specified in individual arms.
Other Names:
Drug: Placebo
Etrolizumab-matching placebo will be administered as per regimen specified in individual arms.
|
| Experimental: Induction Phase - Cohort 1 (Exploratory): Etrolizumab 105 mg Cohort 1 enrolled participants first before Cohorts 2 and 3 in order to conduct an exploratory analysis on induction data. Participants randomized to this arm will receive one SC injection of etrolizumab (105 mg) at Weeks 0, 4, 8, 12 and one SC injection of etrolizumab-matching placebo at Week 2 during the 14-week Induction Phase. In order to preserve the masking, participants will also receive one SC injection of etrolizumab-matching placebo at Weeks 0, 4, 8, and 12. |
Drug: Etrolizumab
Etrolizumab will be administered as per regimen specified in individual arms.
Other Names:
Drug: Placebo
Etrolizumab-matching placebo will be administered as per regimen specified in individual arms.
|
| Placebo Comparator: Induction Phase - Cohort 1 (Exploratory): Placebo Cohort 1 enrolled participants first before Cohorts 2 and 3 in order to conduct an exploratory analysis on induction data. Participants randomized to this arm will receive two SC injections of etrolizumab-matching placebo at Weeks 0, 4, 8, and 12 (and one SC injection of etrolizumab-matching placebo at Week 2) during the 14-week Induction Phase, in order to preserve the masking. |
Drug: Placebo
Etrolizumab-matching placebo will be administered as per regimen specified in individual arms.
|
| Experimental: Induction Phase - Cohort 2 (Open-Label): Etrolizumab 210 mg Cohort 2 is enrolling participants after Cohort 1 and is considered a "feeder" cohort to help achieve the necessary sample size for the Maintenance Phase. Participants randomized to this arm will receive one SC injection of open-label etrolizumab (210 mg) at Weeks 0, 2, 4, 8, and 12 during the 14-week Induction Phase. In order to preserve the masking for the dose of etrolizumab, participants will also receive one SC injection of etrolizumab-matching placebo at Weeks 0, 4, 8, and 12. |
Drug: Etrolizumab
Etrolizumab will be administered as per regimen specified in individual arms.
Other Names:
Drug: Placebo
Etrolizumab-matching placebo will be administered as per regimen specified in individual arms.
|
| Experimental: Induction Phase - Cohort 2 (Open-Label): Etrolizumab 105 mg Cohort 2 is enrolling participants after Cohort 1 and is considered a "feeder" cohort to help achieve the necessary sample size for the Maintenance Phase. Participants randomized to this arm will receive one SC injection of open-label etrolizumab (105 mg) at Weeks 0, 4, 8, 12 and one SC injection of etrolizumab-matching placebo at Week 2 during the 14-week Induction Phase. In order to preserve the masking of the dose of etrolizumab, participants will also receive one SC injection of etrolizumab-matching placebo at Weeks 0, 4, 8, and 12. |
Drug: Etrolizumab
Etrolizumab will be administered as per regimen specified in individual arms.
Other Names:
Drug: Placebo
Etrolizumab-matching placebo will be administered as per regimen specified in individual arms.
|
| Experimental: Induction Phase - Cohort 3 (Pivotal): Etrolizumab 210 mg Cohort 3 is the last to enroll participants (after Cohort 2) and will be the pivotal cohort for the Induction Phase. Participants randomized to this arm will receive one SC injection of etrolizumab (210 mg) at Weeks 0, 2, 4, 8, and 12 during the 14-week Induction Phase. In order to preserve the masking, participants will also receive one SC injection of etrolizumab-matching placebo at Weeks 0, 4, 8, and 12. |
Drug: Etrolizumab
Etrolizumab will be administered as per regimen specified in individual arms.
Other Names:
Drug: Placebo
Etrolizumab-matching placebo will be administered as per regimen specified in individual arms.
|
| Experimental: Induction Phase - Cohort 3 (Pivotal): Etrolizumab 105 mg Cohort 3 is the last to enroll participants (after Cohort 2) and will be the pivotal cohort for the Induction Phase. Participants randomized to this arm will receive one SC injection of etrolizumab (105 mg) at Weeks 0, 4, 8, 12 and one SC injection of etrolizumab-matching placebo at Week 2 during the 14-week Induction Phase. In order to preserve the masking, participants will also receive one SC injection of etrolizumab-matching placebo at Weeks 0, 4, 8, and 12. |
Drug: Etrolizumab
Etrolizumab will be administered as per regimen specified in individual arms.
Other Names:
Drug: Placebo
Etrolizumab-matching placebo will be administered as per regimen specified in individual arms.
|
| Placebo Comparator: Induction Phase - Cohort 3 (Pivotal): Placebo Cohort 3 is the last to enroll participants (after Cohort 2) and will be the pivotal cohort for the Induction Phase. Participants randomized to this arm will receive two SC injections of etrolizumab-matching placebo at Weeks 0, 4, 8, and 12 (and one SC injection of etrolizumab-matching placebo at Week 2) during the 14-week Induction Phase, in order to preserve the masking. |
Drug: Placebo
Etrolizumab-matching placebo will be administered as per regimen specified in individual arms.
|
| Placebo Comparator: Maintenance Phase - Placebo Responders: Placebo Participants who received placebo during the Induction Phase (from Cohorts 1 and 3) and achieved a CDAI-70 response at Week 14 will undergo a sham randomization into the Maintenance Phase. Placebo responders from induction will receive blinded maintenance treatment with an SC injection of placebo once every 4 weeks (q4w) from Week 16 to Week 64. |
Drug: Placebo
Etrolizumab-matching placebo will be administered as per regimen specified in individual arms.
|
| Placebo Comparator: Maintenance Phase - Etrolizumab Responders: Placebo Participants who received etrolizumab during the Induction Phase (from Cohorts 1-3) and achieved a CDAI-70 response at Week 14 without the use of rescue therapy will be re-randomized into the Maintenance Phase. Etrolizumab responders from induction who are re-randomized to this arm will receive blinded maintenance treatment with an SC injection of placebo q4w from Week 16 to Week 64. |
Drug: Placebo
Etrolizumab-matching placebo will be administered as per regimen specified in individual arms.
|
| Experimental: Maintenance Phase - Etrolizumab Responders: Etrolizumab 105 mg Participants who received etrolizumab during the Induction Phase (from Cohorts 1-3) and achieved a CDAI-70 response at Week 14 without the use of rescue therapy will be re-randomized into the Maintenance Phase. Etrolizumab responders from induction who are re-randomized to this arm will receive blinded maintenance treatment with an SC injection of etrolizumab (105 mg) q4w from Week 16 to Week 64. |
Drug: Etrolizumab
Etrolizumab will be administered as per regimen specified in individual arms.
Other Names:
|
| No Intervention: Maintenance Phase - Non-Responders: Safety Follow-Up/GA29145 All participants from Cohorts 1-3 who are considered non-responders after the Induction Phase at Week 14 may be eligible to enter the open-label extension study GA29145 (NCT02403323) and/or undergo a 12-week safety follow-up. |
Outcome Measures
Primary Outcome Measures
- Induction Phase: Percentage of Participants with Clinical Remission at Week 14 [Baseline and Week 14]
Clinical remission is defined as liquid/soft stool frequency (SF) mean daily score less than or equal (≤)3 and abdominal pain mean daily score ≤1, with no worsening in either subscore compared to baseline, averaged over the 7 days prior to visit.
- Induction Phase: Percentage of Participants with Endoscopic Improvement at Week 14 [Baseline and Week 14]
Endoscopic improvement is defined as 50 percent (%) reduction from baseline in Simplified Endoscopic Index for Crohn's Disease (SES-CD) score.
- Maintenance Phase: Percentage of Participants with Clinical Remission at Week 66 [Baseline and Week 66]
Clinical remission is defined as SF mean daily score ≤3 and abdominal pain mean daily score ≤1, with no worsening in either subscore compared to baseline, averaged over the 7 days prior to visit.
- Maintenance Phase: Percentage of Participants with Endoscopic Improvement at Week 66 [Baseline and Week 66]
Endoscopic improvement is defined as 50% reduction from baseline in SES-CD score.
Secondary Outcome Measures
- Induction Phase: Percentage of Participants with Clinical Remission at Week 6 [Baseline and Week 6]
Clinical remission is defined as SF mean daily score ≤3 and abdominal pain mean daily score ≤1, with no worsening in either subscore compared to baseline, averaged over the 7 days prior to visit.
- Induction Phase: Percentage of Participants with SES-CD Score ≤4 (≤2 for Ileal Participants), with No Segment Having a Subcategory Score Greater than (>)1, at Week 14 [Week 14]
- Induction Phase: Change from Baseline in Crohn's Disease-Patient-Reported Outcome Signs and Symptoms (CD-PRO/SS) Score at Week 14 [Baseline and Week 14]
- Maintenance Phase: Percentage of Participants with Clinical Remission at Week 66, Among Those who Achieved Clinical Remission at Week 14 [Baseline, Weeks 14 and 66]
Clinical remission is defined as SF mean daily score ≤3 and abdominal pain mean daily score ≤1, with no worsening in either subscore compared to baseline, averaged over the 7 days prior to visit.
- Maintenance Phase: Percentage of Participants with Corticosteroid-Free Clinical Remission at Week 66, Among Those who Were Receiving Corticosteroids at Baseline [Baseline and Week 66]
Clinical remission is defined as SF mean daily score ≤3 and abdominal pain mean daily score ≤1, with no worsening in either subscore compared to baseline, averaged over the 7 days prior to visit.
- Maintenance Phase: Percentage of Participants with Endoscopic Improvement at Week 66 Among Participants who Achieved Endoscopic Improvement at Week 14 [Baseline, Weeks 14 and 66]
Endoscopic improvement is defined as 50% reduction from baseline in SES-CD score.
- Maintenance Phase: Percentage of Participants with SES-CD Score ≤4 (≤2 for Ileal Participants), with No Segment Having a Subcategory Score >1, at Week 66 [Week 66]
- Maintenance Phase: Percentage of Participants with Durable Clinical Remission [Week 14 up to Week 66 (assessed at Weeks 24, 28, 32, 44, 56, and 66)]
Clinical remission is defined as SF mean daily score ≤3 and abdominal pain mean daily score ≤1, with no worsening in either subscore compared to baseline, averaged over the 7 days prior to visit. Durable clinical remission was defined as clinical remission at ≥4 of the 6 in-clinic assessment visits conducted during the Maintenance Phase at Weeks 24, 28, 32, 44, 56, and 66.
- Maintenance Phase: Percentage of Participants with Corticosteroid-Free Clinical Remission for at Least 24 Weeks at Week 66, Among Those who Were Receiving Corticosteroids at Baseline [Baseline and from Week 14 up to Week 66]
Clinical remission is defined as SF mean daily score ≤3 and abdominal pain mean daily score ≤1, with no worsening in either subscore compared to baseline, averaged over the 7 days prior to visit. Percentage of participants with clinical remission who will be off corticosteroids for at least 24 weeks prior to Week 66 will be reported.
- Maintenance Phase: Change from Baseline in CD-PRO/SS Score at Week 66 [Baseline and Week 66]
- Overall Number of Participants who Experienced at Least One Adverse Event by Severity, According to National Cancer Institute Common Terminology Criteria for Adverse Events, Version 4.0 (NCI-CTCAE v4.0) [From Baseline up to Week 78]
- Overall Number of Participants with Adverse Events Leading to Study Drug Discontinuation [From Baseline up to Week 78]
- Overall Number of Participants who Experienced at Least One Infection-Related Adverse Event by Severity, According to NCI-CTCAE v4.0 [From Baseline up to Week 78]
- Overall Number of Participants who Experienced at Least One Infection-Related Serious Adverse Event [From Baseline up to Week 78]
- Overall Number of Participants who Experienced at Least One Injection-Site Reaction by Severity, According to NCI-CTCAE v4.0 [From Baseline up to Week 78]
- Overall Number of Participants who Experienced at Least One Hypersensitivity Reaction by Severity, According to NCI-CTCAE v4.0 [From Baseline up to Week 78]
- Overall Number of Participants who Develop Malignancies [From Baseline up to Week 78]
- Percentage of Participants With Anti-Therapeutic Antibodies (ATAs) to Etrolizumab [Baseline, Pre-dose (Hour 0) on Weeks 4, 14, 24, 32, 44, 66 or early termination, 12 weeks after last dose (up to Week 78)]
- Observed Trough Serum Concentration (Cmin) of Etrolizumab [Pre-dose (Hour 0) at Baseline and Weeks 0, 10, 14, 16, 24, 28, 32, 44, and 66 or early termination (up to Week 66)]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Moderately to severely active Crohn's Disease (CD) as determined by the CDAI, patient reported outcomes and endoscopically defined disease activity in the ileum and/or colon
-
Intolerance, refractory disease, or no response to corticosteroids (CS), immunosuppressants (IS), or anti-TNF therapy within 5 years from screening. Participants who have not previously demonstrated inadequate response or intolerance to one or more anti-TNF therapies are eligible to participate in the study provided they are intolerant or refractory to CS or IS therapy
-
Use of effective contraception as defined by the protocol
Exclusion Criteria:
-
A history of, or current conditions affecting the digestive tract, such as ulcerative colitis, indeterminate colitis, fistulizing disease, abdominal or perianal abscess, adenomatous colonic polyps not excised, colonic mucosal dysplasia, and short bowel syndrome
-
Planned surgery for CD
-
Ileostomy or colostomy
-
Has received non-permitted inflammatory bowel disease (IBD) therapies (including natalizumab, vedolizumab, and efalizumab, as stated in the protocol)
-
Any prior treatment with ustekinumab within 14 weeks prior to randomization
-
Chronic hepatitis B or C infection, human immunodeficiency virus (HIV), active or latent tuberculosis (participants with prior history of Bacillus Calmette-Guérin [BCG] vaccination must pass protocol-defined screening criteria)
-
Sinus tract with evidence for infection (e.g., purulent discharge) in the clinical judgment of the investigator. Fistulas related to CD are not exclusionary
-
Any prior treatment with anti-adhesion molecules (e.g., anti-mucosal addressin cell adhesion molecule [anti-MAdCAM-1])
-
Any major episode of infection requiring treatment with intravenous antibiotics ≤8 weeks prior to screening or oral antibiotics ≤4 weeks prior to screening. Treatment with antibiotics as adjunctive therapy for CD in the absence of documented infection is not exclusionary
-
Hospitalization (other than for elective reasons) within 4 weeks prior to randomization
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Valley Gastroenterology Consultants | Arcadia | California | United States | 91006 |
| 2 | University of California San Diego Medical Center | La Jolla | California | United States | 92093-5354 |
| 3 | VA Long Beach Healthcare System | Long Beach | California | United States | 90822 |
| 4 | Digestive Care Associates, A Medical Corporation | San Carlos | California | United States | 94070 |
| 5 | SDG Clinical Research | San Diego | California | United States | 92103 |
| 6 | University of California at San Francisco (PARENT); Gastroenterology, Hepatology & Nutrition | San Francisco | California | United States | 94158 |
| 7 | Peak Gastroenterology Associates; Gastroenterology | Colorado Springs | Colorado | United States | 80907 |
| 8 | Innovative Medical Research of South Florida | Aventura | Florida | United States | 33180 |
| 9 | West Central Gastroenterology d/b/a Gastro Florida | Clearwater | Florida | United States | 33762 |
| 10 | University of Florida College of Medicine | Gainesville | Florida | United States | 32610 |
| 11 | Borland-Groover Clinic | Jacksonville | Florida | United States | 32256 |
| 12 | IMIC, Inc | Miami Beach | Florida | United States | 33140 |
| 13 | FQL Research, LLC | Miramar | Florida | United States | 33025 |
| 14 | Advanced Research Institute, Inc. | Trinity | Florida | United States | 34655 |
| 15 | Shafran Gastroenterology Center | Winter Park | Florida | United States | 32789 |
| 16 | Emory University Hospital | Atlanta | Georgia | United States | 30308 |
| 17 | Atlanta Gastroenterology Associates | Atlanta | Georgia | United States | 30342 |
| 18 | Gastrointestinal Diseases Research | Columbus | Georgia | United States | 31904 |
| 19 | Atlanta Center for Gastroenterology, PC | Decatur | Georgia | United States | 30033 |
| 20 | Gastroenterology Associates of Central Georgia | Macon | Georgia | United States | 31201 |
| 21 | Gastrointestinal Specialists of Georgia, PC | Marietta | Georgia | United States | 30060 |
| 22 | Advanced Clinical Research | Meridian | Idaho | United States | 83642 |
| 23 | Northwestern University-Feinberg School of Medicine; Division of Gastroenterology and Hepatology | Chicago | Illinois | United States | 60611 |
| 24 | The University of Chicago Medical Center | Chicago | Illinois | United States | 60637 |
| 25 | NorthShore University HealthSystem; Evanston Hospital | Evanston | Illinois | United States | 60201 |
| 26 | Southwest Gastroenterology; DM Clinical Research | Oak Lawn | Illinois | United States | 60453-3767 |
| 27 | Carle Foundation Hospital | Urbana | Illinois | United States | 61801-2500 |
| 28 | Cotton-O'Neil Clinical Research Center, Digestive Health | Topeka | Kansas | United States | 66606 |
| 29 | Gastroenterology Associates, LLC | Baton Rouge | Louisiana | United States | 70809 |
| 30 | Louisiana Research Center, LLC | Shreveport | Louisiana | United States | |
| 31 | Commonwealth Clinical Studies | Brockton | Massachusetts | United States | 02302 |
| 32 | University of Michigan Health System | Ann Arbor | Michigan | United States | 48109-0666 |
| 33 | Gastroenterology Associates of Western Michigan, P.L.C. | Grand Rapids | Michigan | United States | 49506 |
| 34 | Center for Digestive Health | Troy | Michigan | United States | 48098 |
| 35 | Henry Ford Health System | West Bloomfield | Michigan | United States | 48322 |
| 36 | Mayo Clinic - Rochester; Gastrology | Rochester | Minnesota | United States | 55905 |
| 37 | University of Mississippi Medical Center; Division of Gastroenterology | Jackson | Mississippi | United States | 39216 |
| 38 | Ehrhardt Clinical Research, LLC | Belton | Missouri | United States | 64012 |
| 39 | Concorde Medical Group | New York | New York | United States | 10016 |
| 40 | Weill Cornell Medical College (WCMC) - Judith Jaffe Multiple Sclerosis Center (JJMSC) | New York | New York | United States | 10021 |
| 41 | Lenox Hill Hospital | New York | New York | United States | 10075 |
| 42 | University of North Carolina At Chapel Hill | Chapel Hill | North Carolina | United States | 27514 |
| 43 | Charlotte Gastroenterology and Hepatology, P.L.L.C | Charlotte | North Carolina | United States | 28207 |
| 44 | Kinston Medical Specialists | Kinston | North Carolina | United States | 28501 |
| 45 | Consultants for Clinical Research Inc. | Cincinnati | Ohio | United States | 45219 |
| 46 | Great Lakes Gastroenterology Research, LLC | Mentor | Ohio | United States | 44060 |
| 47 | Digestive Disease Specialists, Inc. | Oklahoma City | Oklahoma | United States | 73112 |
| 48 | Great Lakes Medical Research, LLC | Harrisburg | Pennsylvania | United States | 17110 |
| 49 | Innovative Clinical Research | Greenville | South Carolina | United States | 29604 |
| 50 | Gastroenterology Center of the MidSouth PC | Germantown | Tennessee | United States | 38138 |
| 51 | Vanderbilt University Medical Center | Nashville | Tennessee | United States | 37232 |
| 52 | Texas Digestive Disease Consultants - Dallas | Dallas | Texas | United States | 75231 |
| 53 | University of Texas Southwestern Medical Center; Internal Medicne | Dallas | Texas | United States | 75390-9151 |
| 54 | Baylor College of Medicine; Gastroenterology | Houston | Texas | United States | 77030 |
| 55 | Methodist Hospital Research Institute | Houston | Texas | United States | 77030 |
| 56 | Wellness Clinical Research Center | San Antonio | Texas | United States | 78232 |
| 57 | Texas Digestive Disease Consultants - Southlake | Southlake | Texas | United States | 76092 |
| 58 | Tyler Research Institute, LLC | Tyler | Texas | United States | 75701 |
| 59 | Ericksen Research and Development | Clinton | Utah | United States | 84015 |
| 60 | University of Utah School of Medicine | Salt Lake City | Utah | United States | 84132 |
| 61 | McGuire Research Institute; Gastroenterology | Richmond | Virginia | United States | 23249 |
| 62 | Digestive Disease Institute; Virginia Mason Medical Center | Seattle | Washington | United States | 98101 |
| 63 | University of Wisconsin | Madison | Wisconsin | United States | 53792 |
| 64 | Hospital Italiano | Buenos Aires | Argentina | C1181ACH | |
| 65 | The Canberra Hospital | Garran | Australian Capital Territory | Australia | 2065 |
| 66 | Bankstown-Lidcombe Hospital | Bankstown | New South Wales | Australia | 2200 |
| 67 | Concord Repatriation General Hospital | Concord | New South Wales | Australia | 2139 |
| 68 | Royal Brisbane and Women's Hospital | Herston | Queensland | Australia | 4029 |
| 69 | University of the Sunshine Coast | Sippy Downs | Queensland | Australia | 4556 |
| 70 | Mater Adult Hospital | South Brisbane | Queensland | Australia | 4101 |
| 71 | Princess Alexandra Hospital | Woolloongabba | Queensland | Australia | 4102 |
| 72 | Flinders Medical Centre | Bedford Park | South Australia | Australia | 5042 |
| 73 | Monash Medical Centre Clayton | Clayton | Victoria | Australia | 3168 |
| 74 | St Vincent's Hospital Melbourne | Fitzroy | Victoria | Australia | 3065 |
| 75 | Footscray Hospital; Gastroenterology | Footscray | Victoria | Australia | 3011 |
| 76 | St Frances Xavier Cabrini Hospital | Malvern | Victoria | Australia | 3144 |
| 77 | Alfred Hospital | Melbourne | Victoria | Australia | 3004 |
| 78 | Royal Melbourne Hospital; Department of Colorectal Medicine and Genetics | Parkville | Victoria | Australia | 3050 |
| 79 | Fiona Stanley Hospital | Murdoch | Western Australia | Australia | 6150 |
| 80 | LKH - Universitätsklinikum der PMU Salzburg | Salzburg | Austria | 5020 | |
| 81 | Medizinische Universität Wien | Wien | Austria | 1090 | |
| 82 | CHU St Pierre (St Pierre) | Brussels | Belgium | 1000 | |
| 83 | UZ Brussel | Brussel | Belgium | 1090 | |
| 84 | Hospital Erasme | Bruxelles | Belgium | 1070 | |
| 85 | UZ Antwerpen | Edegem | Belgium | 2650 | |
| 86 | AZ Maria Middelares | Gent | Belgium | 9000 | |
| 87 | UZ Leuven; Maag, -darm en leverziekten/endoscopie - Endoscopy | Leuven | Belgium | 3000 | |
| 88 | Hospital Universitario Walter Cantidio - UFC | Fortaleza | CE | Brazil | 60430-370 |
| 89 | L2IP -Instituto de Pesquisas Clínicas Ltda. | Brasilia | DF | Brazil | 70200-730 |
| 90 | CEDOES - Diagnóstico e Pesquisa | Vitoria | ES | Brazil | 29055-450 |
| 91 | Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda | Goiânia | GO | Brazil | 74535-170 |
| 92 | Hospital Felicio Rocho | Belo Horizonte | MG | Brazil | 30110-068 |
| 93 | Eurolatino Pesquisas Médicas Ltda. | Uberlandia | MG | Brazil | 38411-186 |
| 94 | Centro Digestivo de Curitiba | Curitiba | PR | Brazil | 80430-160 |
| 95 | Hospital Universitario Clementino Fraga Filho - UFRJ; Gastroenterologia | Rio de Janeiro | RJ | Brazil | 21941-590 |
| 96 | Instituto Brasil de Pesquisa Clínica-IBPCLIN S/A | Rio de Janeiro | RJ | Brazil | 22271-100 |
| 97 | Hospital São Vicente de Paulo; Institute of Education and Reseach / Cardiovascular Research Unit | Passo Fundo | RS | Brazil | 99010-080 |
| 98 | Hospital das Clinicas - UFRGS | Porto Alegre | RS | Brazil | 90035-903 |
| 99 | Hospital Ernesto Dornelles | Porto Alegre | RS | Brazil | 90160-092 |
| 100 | Oncoeste Pesquisa Clinica - HUST - Hospital Universitario Santa Terezinha | Joacaba | SC | Brazil | 89600-000 |
| 101 | UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu | Botucatu | SP | Brazil | 18618-970 |
| 102 | Allergisa Pesquisa Dermato-Cosmética Ltda | Campinas | SP | Brazil | 13084-791 |
| 103 | Pesquisare Saúde Sociedade Simples | Santo Andre | SP | Brazil | 09080-000 |
| 104 | Praxis Pesquisa Médica | Santo Andre | SP | Brazil | 09090-790 |
| 105 | Hospital Estadual Mario Covas | Santo Andre | SP | Brazil | 09190-610 |
| 106 | Hospital de Base de Sao Jose do Rio Preto | Sao Jose do Rio Preto | SP | Brazil | 15090-000 |
| 107 | Hospital Sírio-Libanês | Sao Paulo | SP | Brazil | 01308-050 |
| 108 | Universidade Federal de Sao Paulo - UNIFES | Sao Paulo | SP | Brazil | 04026-000 |
| 109 | Hospital do Servidor Público Estadual/HSPE-SP | São Paulo | SP | Brazil | 04039-901 |
| 110 | "City Clinic UMHAC" EOOD | Sofia | Bulgaria | 1407 | |
| 111 | UMHAT "Sv. Ivan Rilski", EAD | Sofia | Bulgaria | 1431 | |
| 112 | UMHAT Tsaritsa Yoanna - ISUL, EAD | Sofia | Bulgaria | 1527 | |
| 113 | University of Calgary | Calgary | Alberta | Canada | T2N 2T9 |
| 114 | Zeidler Ledcor Centre - University of Alberta; Division of Gasroenterology | Edmonton | Alberta | Canada | T6G 2X8 |
| 115 | (G.I.R.I.) GI Research Institute | Vancouver | British Columbia | Canada | V6Z 2K5 |
| 116 | Winnipeg Regional Health Authority | Winnipeg | Manitoba | Canada | R3A 1R9 |
| 117 | Queen Elizabeth II Health Sciences Centre; Gastroenterology Research | Halifax | Nova Scotia | Canada | B3H 1V7 |
| 118 | University Hospital - London Health Sciences Centre | London | Ontario | Canada | N6A 5A5 |
| 119 | Taunton Health Centre | Oshawa | Ontario | Canada | L1H 7K4 |
| 120 | The Ottawa Hospital - Riverside Campus; Gastrointestinal Clinical Research Unit | Ottawa | Ontario | Canada | K1H 1A2 |
| 121 | Mount Sinai Hospital | Toronto | Ontario | Canada | M5G 1X5 |
| 122 | Toronto Digestive Disease Associates | Vaughan | Ontario | Canada | L4L 4Y7 |
| 123 | Hôpital Maisonneuve - Rosemont | Montreal | Quebec | Canada | H1T 2M4 |
| 124 | McGill University Health Centre - Glen Site | Montreal | Quebec | Canada | H4A 3J1 |
| 125 | Royal University Hospital | Saskatoon | Saskatchewan | Canada | S7N 0W8 |
| 126 | Clinical Hospital Centre Osijek | Osijek | Croatia | 31000 | |
| 127 | General Hospital Pula | Pula | Croatia | 52100 | |
| 128 | Clinical Hospital Center Sestre Milosrdnice | Zagreb | Croatia | 10000 | |
| 129 | Clinical Hospital Sveti Duh | Zagreb | Croatia | 10000 | |
| 130 | University Hospital Center Zagreb | Zagreb | Croatia | 10000 | |
| 131 | Vojenska nemocnice Brno | Brno | Czechia | 636 00 | |
| 132 | Fakultni nemocnice u sv. Anny v Brne | Brno | Czechia | 656 91 | |
| 133 | Nemocnice Ceske Budejovice a.s. | Ceske Budejovice | Czechia | 370 01 | |
| 134 | Gastroenterologie s.r.o. | Hradec Kralove | Czechia | 500 02 | |
| 135 | Fakultni nemocnice Hradec Kralove | Hradec Kralove | Czechia | 500 05 | |
| 136 | Hepato-Gastroenterologie HK, s.r.o. | Hradec Kralove | Czechia | 500 12 | |
| 137 | PreventaMed, s.r.o. | Olomouc | Czechia | 779 00 | |
| 138 | Fakultni nemocnice Ostrava | Ostrava - Poruba | Czechia | 708 52 | |
| 139 | Klinicke centrum ISCARE Lighthouse | Praha 7 | Czechia | 170 00 | |
| 140 | Fakultni nemocnice Kralovske Vinohrady | Praha | Czechia | 110 34 | |
| 141 | West Tallinn Central Hospital | Tallinn | Estonia | 10617 | |
| 142 | North Estonia Medical Centre Foundation | Tallinn | Estonia | 13419 | |
| 143 | Tartu University Hospital | Tartu | Estonia | 51014 | |
| 144 | CHU Amiens - Hopital Sud | Amiens | France | 80054 | |
| 145 | CHU de Caen - Hopital Cote de Nacre | Caen | France | 14033 | |
| 146 | CHU Clermont Ferrand - Hôpital d'Estaing | Clermont Ferrand cedex 1 | France | 63003 | |
| 147 | Hôpital Beaujon | Clichy cedex | France | 92110 | |
| 148 | CHU de Grenoble - Hôpital Nord | Grenoble | France | 38043 | |
| 149 | Centre Hospitalier Départemental Les Oudairies | La Roche sur Yon | France | 85025 | |
| 150 | Hopital Claude Huriez - CHU Lille | Lille | France | 59037 | |
| 151 | CHU NANTES - Hôtel Dieu; Pharmacy | Nantes | France | 44093 | |
| 152 | CHU Nice - Hopital de l'Archet 2 | Nice | France | 06202 | |
| 153 | Hôpital Saint-Louis | Paris | France | 75475 | |
| 154 | Groupe Hospitalier Sud - Hôpital Haut-Lévêque - USN | Pessac | France | 33604 | |
| 155 | Centre Hospitalier Lyon Sud; Service de Gastro-Enterologie | Pierre-Benite | France | 69495 | |
| 156 | CHU du Reims - Hopital Robert Debré | Reims | France | 51092 | |
| 157 | CHU Rennes - Hopital Pontchaillou | Rennes cedex 09 | France | 35033 | |
| 158 | CHU Saint Etienne - Hôpital Nord | Saint Etienne | France | 42055 | |
| 159 | Höpital Hautepierre; Pediatrie1 | Strasbourg | France | 67098 | |
| 160 | Hôpital de Brabois Adultes | Vandoeuvre-les-nancy | France | 54511 | |
| 161 | Charite-Campus Virchow Klinikum; Hepatologie und Gastroenterologie | Berlin | Germany | 13353 | |
| 162 | Charité Campus Virchow-Klinikum; Department of Cardiology | Berlin | Germany | 13353 | |
| 163 | Krankenhaus Waldfriede e. V. | Berlin | Germany | 14163 | |
| 164 | Berufsgenossenschaftliches Universitaetsklinikum Bergmannsheil GmbH | Bochum | Germany | 44789 | |
| 165 | Staedisches Klinikum Brandenburg | Brandenburg an der Havel | Germany | 14770 | |
| 166 | Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden | Dresden | Germany | 01307 | |
| 167 | Klinikum der Johann Wolfgang Goethe-Universitaet | Frankfurt | Germany | 60590 | |
| 168 | Universitaetsklinikum Halle (Saale) | Halle | Germany | 06120 | |
| 169 | Gastroenterologie | Hamburg | Germany | 20249 | |
| 170 | Medizinische Hochschule Hannover; Gastroenterology and Hepatology dept | Hannover | Germany | 30625 | |
| 171 | Universitaetsklinikum Schleswig-Holstein, Campus Kiel | Kiel | Germany | 24116 | |
| 172 | Universitätsklinikum Koeln | Koeln | Germany | 50937 | |
| 173 | Universitaetsklinikum Magdeburg A.oe.R; Division of Cardiology | Magdeburg | Germany | 39120 | |
| 174 | Klinikum Mannheim GmbH Universitätsklinikum | Mannheim | Germany | 68167 | |
| 175 | Universitaetsklinikum Muenster | Muenster | Germany | 48149 | |
| 176 | Klinikum rechts der Isar der Technischen Universität München | Munchen | Germany | 81675 | |
| 177 | Isar Klinik GmbH | München | Germany | 80331 | |
| 178 | Gemeinschaftspraxis | Offenburg | Germany | 77652 | |
| 179 | Universitaetsklinikum Tuebingen | Tuebingen | Germany | 72076 | |
| 180 | Universitaetsklinikum Ulm | Ulm | Germany | 89081 | |
| 181 | Bekes Megyei Kozponti Korhaz Dr. Rethy Pal Tagkorhaza | Bekescsaba | Hungary | 5600 | |
| 182 | Obudai Egeszsegugyi Centrum Kft. | Budapest | Hungary | 1036 | |
| 183 | Semmelweis Egyetem | Budapest | Hungary | 1083 | |
| 184 | Eszak-Kozep-budai Centrum, Uj Szent Janos Korhaz es Szakrendelo | Budapest | Hungary | 1125 | |
| 185 | Pannonia Maganorvosi Centrum | Budapest | Hungary | 1135 | |
| 186 | Debreceni Egyetem | Debrecen | Hungary | 4032 | |
| 187 | Petz Aladar Megyei Oktato Korhaz | Gyor | Hungary | 9024 | |
| 188 | Pest Megyei Flor Ferenc Korhaz | Kistarcsa | Hungary | 2143 | |
| 189 | Pecsi Tudomanyegyetem | Pecs | Hungary | 7624 | |
| 190 | Csongrad Megyei Dr. Bugyi Istvan Korhaz | Szentes | Hungary | 6600 | |
| 191 | Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz | Székesfehérvár | Hungary | 8000 | |
| 192 | Haemek Medical Center | Afula | Israel | 18101 | |
| 193 | Soroka University Medical Centre | Beer Sheva | Israel | 8410101 | |
| 194 | Wolfson Medical Center; Obstetrics and Gynecology | Holon | Israel | 5822012 | |
| 195 | Shaare Zedek Medical Center | Jerusalem | Israel | 9103102 | |
| 196 | Hadassah University Hospital - Ein Kerem | Jerusalem | Israel | 9112001 | |
| 197 | Holy Family Hospital | Nazareth | Israel | 16100 | |
| 198 | Rabin Medical Center-Beilinson Campus | Petach Tikva | Israel | 4941492 | |
| 199 | Tel Aviv Sourasky Medical Center; Pharmacy | Tel Aviv | Israel | 6423906 | |
| 200 | A.O.U. Policlinico di Modena | Modena | Emilia-Romagna | Italy | 40124 |
| 201 | Azienda Ospedaliera San Camillo Forlanini | Roma | Lazio | Italy | 00152 |
| 202 | Policlinico Universitario Agostino Gemelli; Farmacia | Roma | Lazio | Italy | 00168 |
| 203 | Asst Fatebenefratelli Sacco (Fatebenefratelli) | Milano | Lombardia | Italy | 20121 |
| 204 | ASST FATEBENEFRATELLI SACCO (Sacco) | Milano | Lombardia | Italy | 20157 |
| 205 | Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda) | Milano | Lombardia | Italy | 20162 |
| 206 | Ospedale di Circolo | Rho | Lombardia | Italy | 20017 |
| 207 | Istituto Clinico Humanitas | Rozzano (MI) | Lombardia | Italy | 20089 |
| 208 | I.R.C.C.S Policlinico San Donato | San Donato Milanese (MI) | Lombardia | Italy | 20097 |
| 209 | Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico | Milano | Molise | Italy | 20122 |
| 210 | Ospedale Umberto I di Torino | Torino | Piemonte | Italy | 10128 |
| 211 | Azienda Ospedaliera Vincenzo Cervello | Palermo | Sicilia | Italy | 90127 |
| 212 | Azienda Ospedaliera Universitaria Careggi | Firenze | Toscana | Italy | 50141 |
| 213 | Inje University Busan Paik Hospital | Busan | Korea, Republic of | 47392 | |
| 214 | Dong-A University Hospital | Busan | Korea, Republic of | 49201 | |
| 215 | Pusan National University Hospital | Busan | Korea, Republic of | 49241 | |
| 216 | Kyungpook National University Hospital | Daegu | Korea, Republic of | 41944 | |
| 217 | Yeungnam Univ. Hospital | Daegu | Korea, Republic of | 705-717 | |
| 218 | Hanyang University Guri Hospital | Gyeonggi-do | Korea, Republic of | 11923 | |
| 219 | Korea University Ansan Hospital | Gyeonggi-do | Korea, Republic of | 15355 | |
| 220 | Seoul National University Bundang Hospital | Seongnam-si | Korea, Republic of | 13605 | |
| 221 | CHA Bundang Medical Centre; CHA university | Seongnam | Korea, Republic of | 13520 | |
| 222 | Seoul National University Hospital | Seoul | Korea, Republic of | 03080 | |
| 223 | Kangbuk Samsung Hospital | Seoul | Korea, Republic of | 03181 | |
| 224 | Severance Hospital, Yonsei University Health System | Seoul | Korea, Republic of | 03722 | |
| 225 | Asan Medical Center | Seoul | Korea, Republic of | 05505 | |
| 226 | Samsung Medical Center | Seoul | Korea, Republic of | 06351 | |
| 227 | Yonsei University Wonju Severance Christian Hospital | Wonju-Si | Korea, Republic of | 220-701 | |
| 228 | Riga East Clinical University Hospital; Clinic Gailezers | Riga | Latvia | LV 1002 | |
| 229 | Pauls Stradins Clinical University Hospital | Rīga | Latvia | LV-1002 | |
| 230 | Hospital of Lithuanian University of Health. Sciences Kaunas Clinics | Kaunas | Lithuania | 50009 | |
| 231 | Vilnius University Hospital Santariskiu Clinic, Public Institution; Cardiology | Vilnius | Lithuania | LT-08661 | |
| 232 | Clinical Research Institute | Tlalnepantla de Baz | Mexico CITY (federal District) | Mexico | 54055 |
| 233 | Centro Regiomontano de Estudios Clínicos Roma S.C. | Monterrey | Nuevo LEON | Mexico | 64610 |
| 234 | Medical Care & Research SA de CV | Mérida | Yucatan | Mexico | 97070 |
| 235 | Amsterdam UMC, Locatie VUMC; Neurology | Amsterdam | Netherlands | 1081 HV | |
| 236 | Amsterdam UMC Location AMC | Amsterdam | Netherlands | 1105 AZ | |
| 237 | Leids Universitair Medisch Centrum | Leiden | Netherlands | 2333 ZA | |
| 238 | Maastricht University Medical Center | Maastricht | Netherlands | 6229 HX | |
| 239 | Erasmus Medisch Centrum | Rotterdam | Netherlands | 3000 CA | |
| 240 | Zuyderland Medisch Centrum - Sittard Geleen | Sittard-Geleen | Netherlands | 6162 BG | |
| 241 | ETZ TweeSteden | Tilburg | Netherlands | 5042AD | |
| 242 | North Shore Hospital | Auckland | New Zealand | 0620 | |
| 243 | Christchurch Hospital NZ | Christchurch | New Zealand | 8011 | |
| 244 | Dunedin Public Hospital | Dunedin | New Zealand | 9016 | |
| 245 | Waikato Hospital | Hamilton | New Zealand | 3248 | |
| 246 | Shakespeare Specialist Group | Takapuna | New Zealand | 0620 | |
| 247 | Tauranga Hospital | Tauranga | New Zealand | 3143 | |
| 248 | SP ZOZ Wojewodzki Szpital Zespolony im. J. Sniadeckiego | Białystok | Poland | 15-275 | |
| 249 | Nasz Lekarz Osrodek Badan Klinicznych | Bydgoszcz | Poland | 85-312 | |
| 250 | Elblaski Szpital Specjalistyczny z Przychodnia SP ZOZ | Elblag | Poland | 82-300 | |
| 251 | ETG Kielce | Kielce | Poland | 25-355 | |
| 252 | Centrum Opieki Zdrowotnej Orkan-Med | Ksawerow | Poland | 95-054 | |
| 253 | Indywidualna Specjalistyczna Praktyka Lekarska | Lublin | Poland | 20-015 | |
| 254 | Allmedica Badania Kliniczne Sp z o.o. Sp K. | Nowy Targ | Poland | 34-400 | |
| 255 | Centrum Medyczne "MEDYK" | Rzeszow | Poland | 35-055 | |
| 256 | Gabinet Lekarski, Bartosz Korczowski | Rzeszów | Poland | 35-302 | |
| 257 | Specjalistyczna Praktyka Lekarska Dr med. Marek Horynski; endoskopia | Sopot | Poland | 81-756 | |
| 258 | Niepubliczny Zaklad Opieki Zdrowotnej SONOMED | Szczecin | Poland | 70-351 | |
| 259 | Twoja Przychodnia-Szczecinskie Centrum Medyczne | Szczecin | Poland | 71-434 | |
| 260 | Gastromed Kopon Zmudzinski i Wspolnicy Sp.j.Specjalistyczne Centrum Gastrologii i Endoskopii Specj | Toruń | Poland | 87-100 | |
| 261 | Centrum Zdrowia MDM | Warszawa | Poland | 00-631 | |
| 262 | Warsaw IBD Point Profesor Kierkus | Warszawa | Poland | 00-728 | |
| 263 | Zespó Przychodni Specjalistycznych PRIMA | Warszawa | Poland | 02-018 | |
| 264 | Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy | Warszawa | Poland | 02-781 | |
| 265 | LexMedica Osrodek Badan Klinicznych | Wroclaw | Poland | 53-114 | |
| 266 | EuroMediCare Szpital Specjalistyczny z Przychodnią we Wrocławiu | Wroclaw | Poland | 54-144 | |
| 267 | PlanetMed sp. z o.o. | Wrocław | Poland | 52-210 | |
| 268 | AppleTreeClinics Sp. z o.o. | Łódź | Poland | 90-349 | |
| 269 | Spitalul Clinic Colentina | Bucharest | Romania | 772202 | |
| 270 | S.C MedLife S.A | Bucuresti | Romania | 010719 | |
| 271 | Centrul de Gastroenterologie Dr. Goldis | Timisoara | Romania | 300002 | |
| 272 | Yusupov Hospital | Moskva | Adygeja | Russian Federation | 127015 |
| 273 | LLC "Novosibirsk GastroCenter" | Novosibirsk | Altaj | Russian Federation | 630007 |
| 274 | Baltic Medicine | St.Petersburg | Leningrad | Russian Federation | 194356 |
| 275 | LLC Medinet | Sankt-peterburg | Sankt Petersburg | Russian Federation | 190103 |
| 276 | North-Western Medical University n.a. I.I. Mechnikov; Rheumatology | Sankt-peterburg | Sankt Petersburg | Russian Federation | 191015 |
| 277 | SBIH City Clinical Hospital #31 | Sankt-peterburg | Sankt Petersburg | Russian Federation | 197110 |
| 278 | SBEI HPE Altai StateMedicalUniversityofMoH andSD | Barnaul | Russian Federation | 656050 | |
| 279 | Irkutsk State Medical Academy of Continuing Education | Irkutsk | Russian Federation | ||
| 280 | SBEIHPE Novosibirsk State Medical University | Novosibirsk | Russian Federation | 630091 | |
| 281 | BHI of Omsk region Clinical Oncology Dispensary | Omsk | Russian Federation | 644013 | |
| 282 | Evromedservis LCC | Pushkin | Russian Federation | 196603 | |
| 283 | SEIHPE "Rostov SMU of MoH of RF" | Rostov-on-Don | Russian Federation | 344022 | |
| 284 | Federal State Military Educational Institution; High Professional Education Military Medical Acad | St. Petersburg | Russian Federation | 194044 | |
| 285 | Pavlov First Saint Petersburg State Medical University | St. Petersburg | Russian Federation | 197022 | |
| 286 | Stavropol Regional Clinical Diagnostic Centre | Stavropol | Russian Federation | 355040 | |
| 287 | Clinical Helth Centre Zvezdara | Belgrade | Serbia | 11000 | |
| 288 | Military Medical Academy | Belgrade | Serbia | 11040 | |
| 289 | Clinical Center Zemun | Belgrade | Serbia | 11080 | |
| 290 | University Hospital Medical Center Bezanijska kosa | Belgrade | Serbia | 11080 | |
| 291 | Clinical Center Nis | NIS | Serbia | 18000 | |
| 292 | Clinical Center of Vojvodina | Novi Sad | Serbia | 21000 | |
| 293 | General Hospital Djordje Joanovic | Zrenjanin | Serbia | 23000 | |
| 294 | IBDcentrum s.r.o. | Bratislava | Slovakia | 83104 | |
| 295 | KM Management spol. s r.o. | Nitra | Slovakia | 94901 | |
| 296 | Endomed, s.r.o. | Vranov nad Topľou | Slovakia | 093 01 | |
| 297 | Accout Center s.r.o. | Šahy | Slovakia | 936 01 | |
| 298 | Dr D Epstein Practice | Cape Town | South Africa | 7405 | |
| 299 | Emmed Research | Pretoria | South Africa | 0002 | |
| 300 | Hospital Universitario de Bellvitge | Hospitalet de Llobregat | Barcelona | Spain | 08907 |
| 301 | Hospital Universitario Puerta de Hierro Majadahonda; Hepatology studies | Majadahonda | Madrid | Spain | 28222 |
| 302 | Hospital Clínic i Provincial; Servicio de Farmacia | Barcelona | Spain | 08036 | |
| 303 | Centro Médico Teknon | Barcelona | Spain | ||
| 304 | Hospital Reina Sofia; Medical Oncology | Cordoba | Spain | 14004 | |
| 305 | Hospital Universitari de Girona Dr Josep Trueta | Girona | Spain | 17007 | |
| 306 | Hospital Juan Ramón Jiménez | Huelva | Spain | 21005 | |
| 307 | Hospital Universitario de la Princesa | Madrid | Spain | 28006 | |
| 308 | Hospital Universitario La Paz | Madrid | Spain | 280146 | |
| 309 | Hospital Universitario de Fuenlabrada | Madrid | Spain | 28942 | |
| 310 | Complejo Hospitalario de Pontevedra | Pontevedra | Spain | 36071 | |
| 311 | Hospital Universitario Virgen Macarena | Sevilla | Spain | 41009 | |
| 312 | Hospital Universitario Virgen del Rocio | Sevilla | Spain | 41013 | |
| 313 | Hospital Universitari i Politecnic La Fe | Valencia | Spain | 46026 | |
| 314 | Hospital Universitario Miguel Servet | Zaragoza | Spain | 50009 | |
| 315 | Inselspital-Universitaetsspital Bern | Bern | Switzerland | 3010 | |
| 316 | Crohn-Colitis Zentrum Bern - Gemeinschaftspraxis Balsiger, Seibold und Partner | Bern | Switzerland | 3012 | |
| 317 | Kantonsspital St.Gallen | St. Gallen | Switzerland | 9007 | |
| 318 | Universitätsspital Zürich | Zürich | Switzerland | 8091 | |
| 319 | Ankara University Medical Faculty | Ankara | Turkey | 06100 | |
| 320 | Hacettepe University Medical Faculty; Gastroenterology | Ankara | Turkey | 06100 | |
| 321 | Gazi University Medical Faculty | Ankara | Turkey | 06500 | |
| 322 | Acibadem Fulya Hospital; Neurology | Istanbul | Turkey | 34349 | |
| 323 | Haydarpasa Numune Training and Research Hospital; Medical Oncology | Istanbul | Turkey | 34668 | |
| 324 | Medeniyet University Goztepe Training and Research Hospital; Chest Diseases | Istanbul | Turkey | 34722 | |
| 325 | Ege University Medical Faculty | Izmir | Turkey | 35100 | |
| 326 | Kocaeli Universitesi Tip Fakultesi; Infectious Diseases | Kocaeli | Turkey | 41380 | |
| 327 | Acibadem Kozyatagi Hospital; Gastroenterology | Kozyataği | Turkey | 34742 | |
| 328 | Medical Center Dopomoga Plus | Kyiv | Chernihiv Governorate | Ukraine | 02123 |
| 329 | Municipal Noncommercial Enterprise City Clinical Hospital | Lviv | Chernihiv Governorate | Ukraine | 79011 |
| 330 | CHI Prof.O.O.Shalimov Kharkiv City Clinical Hospital #2 | Kharkiv | Kharkiv Governorate | Ukraine | 61037 |
| 331 | CI of Healthcare Kharkiv Reg Clin Hosp-Center of Med Emergency & Accident Medicine | Kharkiv | Kharkiv Governorate | Ukraine | 61204 |
| 332 | Kyiv Clinical Hospital on Railway Station of Healthcare Center branch of JSC | Kyiv | Kharkiv Governorate | Ukraine | 01030 |
| 333 | Kyiv Railway Clinical Hospital#2 of Branch Health Center of the PJSC | Kyiv | Kharkiv Governorate | Ukraine | 03049 |
| 334 | Medical Center of Limited Liability Company Medical Clinic Blagomed | Kyiv | KIEV Governorate | Ukraine | 1023 |
| 335 | Med Center of International Institute of Clinical Trials LLC; Medical Center "OK!Clinic+" | Kyiv | KIEV Governorate | Ukraine | 2091 |
| 336 | CI of Kyiv RC Regional Clinical Hospital #2 | Kyiv | KIEV Governorate | Ukraine | 4073 |
| 337 | Salutas Medical Centre | Lviv | KIEV Governorate | Ukraine | 79005 |
| 338 | Lviv Regional Clinical Hospital | Lviv | KIEV Governorate | Ukraine | 79010 |
| 339 | Ivano-Frankivsk Regional Clinical Hospital | Ivano-Frankivsk | Kuban People's Republica | Ukraine | 76000 |
| 340 | RCNECRCH Dept of Surgery, SHEI Ukr BSMU | Chernivtsi | Podolia Governorate | Ukraine | 58002 |
| 341 | Khmelnytska Regional Hospital | Khmelnytskyi | Podolia Governorate | Ukraine | 29000 |
| 342 | Transcarpathian Regional Clinical Hospital n a Andriy Novak; Gastroenterology department | Uzhgorod | Polissya Okruha | Ukraine | 88000 |
| 343 | Kremenchuk first city hospital n.a. O.T. Bohaievskyi; Gastroenterology department | Kremenchuk | Poltava Governorate | Ukraine | 39617 |
| 344 | CI City Hospital #1 | Zaporizhzhia | Tavria Okruha | Ukraine | 69104 |
| 345 | Communal Enterprise Volyn Regional Clinical Hospital of Volyn Regional Council | Lutsk | Volhynian Governorate | Ukraine | 43005 |
| 346 | GI L.T.Malaya Therapy National Institute of the NAMS of Ukraine | Kharkiv | Ukraine | 61039 | |
| 347 | CHI Kharkiv City Clinical Hospital #13 | Kharkiv | Ukraine | 61124 | |
| 348 | Kyiv CCH #18 Dept of Proctology O. O. Bogomolets NMU | Kyiv | Ukraine | 01030 | |
| 349 | City Hospital #1 | Mykolaiv | Ukraine | 54003 | |
| 350 | Railway Transport Odesa CH of Healthcare Ctr Branch of PJSC Ukrainian Railway Dept of Therapy #2 | Odesa | Ukraine | 65059 | |
| 351 | Private Small Enterprise Medical Center Pulse | Vinnytsia | Ukraine | 21001 | |
| 352 | M.I. Pyrogov VRCH Dept of Gastroenterology M.I. Pyrogov VNMU | Vinnytsia | Ukraine | 21018 | |
| 353 | MCIC MC LLC Health Clinic | Vinnytsia | Ukraine | 21029 | |
| 354 | CI Zapor City Multifunctional CH#9 City Center of Gastroenterology SI Zapor MA of PGE of MOHU | Zaporizhzhia | Ukraine | 69095 | |
| 355 | LLC Diaservis | Zaporizhzhia | Ukraine | 69106 | |
| 356 | Royal Victoria Hospital | Belfast | United Kingdom | BT12 6BA | |
| 357 | Addenbrooke's Hospital | Cambridge | United Kingdom | CB2 0QQ | |
| 358 | University Hospital Coventry | Coventry | United Kingdom | CV2 2DX | |
| 359 | Royal Devon and Exeter Hospital (Wonford) | Exeter | United Kingdom | EX2 5DW | |
| 360 | St Mark's Hospital | Harrow | United Kingdom | HA1 3UJ | |
| 361 | Queen Elizabeth Hospital | Kings Lynn | United Kingdom | PE30 4ET | |
| 362 | St James University Hospital | Leeds | United Kingdom | LS9 7TF | |
| 363 | Royal Liverpool University Hospital | Liverpool | United Kingdom | L7 8XP | |
| 364 | Whipps Cross Hospital | London | United Kingdom | E11 1NR | |
| 365 | University College London Hospital | London | United Kingdom | NW1 - 2PG | |
| 366 | Fairfield General Hospital | Manchester | United Kingdom | M8 5RB | |
| 367 | Royal Victoria Infirmary; Stroke unit | Newcastle Upon Tyne | United Kingdom | NE1 4LP | |
| 368 | Nottingham University Hospitals Queen's Medical Centre | Nottingham | United Kingdom | NG7 2UH | |
| 369 | Royal Berkshire Hospital | Reading | United Kingdom | RG1 5AN | |
| 370 | Southampton General Hospital | Southampton | United Kingdom | SO16 6YD | |
| 371 | Royal Stoke University Hospital | Stoke-on-Trent | United Kingdom | ST4 6QG | |
| 372 | Royal Wolverhampton hospital; McHale Building | Wolverhampton | United Kingdom | WV10 0QP |
Sponsors and Collaborators
- Hoffmann-La Roche
Investigators
- Study Director: Clinical Trials, Hoffmann-La Roche
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- GA29144
- 2014-003824-36