GALAXI: A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
Sponsor
Janssen Research & Development, LLC (Industry)
Overall Status
Recruiting
CT.gov ID
NCT03466411
Collaborator
(none)
2,000
831
8
150.1
2.4
0
Study Details
Study Description
Brief Summary
The purpose of this study is to evaluate the clinical efficacy (GALAXI 1), clinical and endoscopic efficacy (GALAXI 2 and GALAXI 3) and safety of guselkumab in participants with Crohn's disease.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2/Phase 3 |
Detailed Description
This program consists of 3 separate studies: a 48-week Phase 2 dose-ranging study (GALAXI 1) and two 48-week Phase 3 confirmatory studies (GALAXI 2 and GALAXI 3). In Phase 2, safety and efficacy of guselkumab dose regimens will be evaluated to support the selection of induction and maintenance dose regimens for confirmatory evaluation in Phase 3. Participants who complete the 48-week Phase 2 or Phase 3 studies may be eligible to enter the long term extension (LTE). Throughout the 3 studies, efficacy, pharmacokinetic, biomarkers, and safety will be assessed.
Study Design
Study Type:
Interventional
Anticipated Enrollment
:
2000 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Double (Participant, Investigator)
Primary Purpose:
Treatment
Official Title:
A Phase 2/3, Randomized, Double-blind, Placebo- and Active-controlled, Parallel-group, Multicenter Protocol to Evaluate the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
Actual Study Start Date
:
Apr 13, 2018
Anticipated Primary Completion Date
:
Jun 3, 2022
Anticipated Study Completion Date
:
Oct 15, 2030
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Phase 2 (GALAXI 1): Group 1 (Guselkumab) Participants will receive guselkumab (Dose 1) by intravenous (IV) infusion, followed by guselkumab (Dose 2) by subcutaneous (SC) injection. Participants who are eligible and willing to continue guselkumab may enter the Long-Term Extension (LTE) phase and continue to receive guselkumab. |
Drug: Guselkumab Dose 1
Guselkumab will be administered by IV infusion.
Drug: Guselkumab Dose 2
Guselkumab will be administered by SC injection.
|
| Experimental: Phase 2 (GALAXI 1): Group 2 (Guselkumab) Participants will receive guselkumab (Dose 3) by intravenous (IV) infusion, followed by guselkumab (Dose 2) by subcutaneous (SC) injection. Participants who are eligible and willing to continue guselkumab may enter the LTE phase and continue to receive guselkumab. |
Drug: Guselkumab Dose 2
Guselkumab will be administered by SC injection.
Drug: Guselkumab Dose 3
Guselkumab will be administered by IV infusion.
|
| Experimental: Phase 2 (GALAXI 1): Group 3 (Guselkumab) Participants will receive guselkumab (Dose 4) by intravenous (IV) infusion, followed by guselkumab (Dose 5) by subcutaneous (SC) injection. Participants who are eligible and willing to continue guselkumab may enter the LTE phase and continue to receive guselkumab. |
Drug: Guselkumab Dose 4
Guselkumab will be administered by IV infusion.
Drug: Guselkumab Dose 5
Guselkumab will be by SC injection.
|
| Active Comparator: Phase 2 (GALAXI 1): Group 4 (Ustekinumab) Participants will receive ustekinumab by intravenous (IV) infusion, followed by subcutaneous (SC) injection. Participants who are eligible and willing to continue ustekinumab may enter the LTE and continue to receive ustekinumab. |
Drug: Ustekinumab
Ustekinumab will be administered by IV infusion and SC injection.
|
| Experimental: Phase 2 (GALAXI 1): Group 5 (Placebo/Ustekinumab) Participants will receive placebo administered by intravenous (IV) infusion. At Week 12, non-responders will receive active treatment (Ustekinumab) administered by intravenous (IV) infusion followed by subcutaneous (SC) injection. Participants who are eligible and willing to continue placebo/ustekinumab may enter the LTE and continue to receive placebo/ustekinumab. |
Drug: Ustekinumab
Ustekinumab will be administered by IV infusion and SC injection.
Drug: Placebo
Placebo will be administered as IV infusion.
|
| Experimental: Phase 3 (GALAXI 2 and 3): Group 1 and Group 2 (Guselkumab) Participants will receive guselkumab by intravenous (IV) infusion, followed by guselkumab by subcutaneous (SC) injection. Participants who are eligible and willing to continue guselkumab may enter the LTE phase and continue to receive guselkumab. |
Drug: Guselkumab
Guselkumab will be administered by IV infusion and SC injection.
|
| Active Comparator: Phase 3 (GALAXI 2 and 3): Group 3 (Ustekinumab) Participants will receive ustekinumab by intravenous (IV) infusion, followed by subcutaneous (SC) injection. Participants who are eligible and willing to continue ustekinumab may enter the LTE phase and continue to receive ustekinumab. |
Drug: Ustekinumab
Ustekinumab will be administered by IV infusion and SC injection.
|
| Experimental: Phase 3 (GALAXI 2 and 3): Group 4 (Placebo/Ustekinumab) Participants will receive placebo administered by intravenous (IV) infusion. At Week 12, non-responders will receive active treatment (ustekinumab) administered by intravenous (IV) infusion followed by subcutaneous (SC) injection. Participants who are eligible and willing to continue placebo/ustekinumab may enter the LTE and continue to receive placebo/ustekinumab. |
Drug: Ustekinumab
Ustekinumab will be administered by IV infusion and SC injection.
Drug: Placebo
Placebo will be administered as IV infusion.
|
Outcome Measures
Primary Outcome Measures
- Phase 2: Change from Baseline in the Crohn's Disease Activity Index (CDAI) Score at Week 12 [Baseline and Week 12]
The CDAI score will be assessed by collecting information on 8 different Crohn's disease-related variables, with scores ranging from 0 to approximately 600. A decrease over time indicates improvement in disease activity.
- Phase 3: Clinical Remission at Week 12 [Week 12]
Clinical remission is defined as CDAI score less than (<) 150 points.
- Phase 3: Endoscopic Response at Week 12 [Week 12]
Endoscopic Response is measured by the Simple Endoscopic Score for Crohn's Disease (SES-CD). The SES-CD is based on the evaluation of 4 endoscopic components across 5 ileocolonic segments, with a total score ranging from 0 to 56.
Secondary Outcome Measures
- Phase 2: Clinical Remission at Week 12 [Week 12]
Clinical remission is defined as CDAI score <150.
- Phase 2: Clinical Response at Week 12 [Week 12]
Clinical response is defined as greater than or equal to (>=) 100-point reduction from baseline in CDAI score or CDAI score <150.
- Phase 2 and Phase 3: Patient-Reported Outcome (PRO)-2 Remission at Week 12 [Week 12]
PRO-2 remission is defined based on average daily stool frequency (SF), average daily abdominal pain (AP) score and no worsening of AP or SF from baseline.
- Phase 2: Clinical-Biomarker Response at Week 12 [Week 12]
Clinical-biomarker response is defined using clinical response based on the CDAI score and reduction from baseline in C-reactive protein (CRP) or fecal calprotectin.
- Phase 2: Endoscopic Response at Week 12 [Week 12]
Endoscopic Response is measured by the SES-CD. The SES-CD is based on the evaluation of 4 endoscopic components across 5 ileocolonic segments, with a total score ranging from 0 to 56.
- Phase 3: Clinical Remission at Week 48 [Week 48]
Clinical remission is defined as CDAI score <150.
- Phase 3: Endoscopic Response at Week 48 [Week 48]
Endoscopic Response is measured by the SES-CD. The SES-CD is based on the evaluation of 4 endoscopic components across 5 ileocolonic segments, with a total score ranging from 0 to 56.
- Phase 3: Durable Clinical Remission at Week 48 [Week 48]
Durable clinical remission is defined as CDAI<150 for most of all visits between Week 12 and Week 48.
- Phase 3: Corticosteroid-Free Clinical Remission at Week 48 [Week 48]
Corticosteroid-free clinical remission is defined as CDAI score <150 at Week 48 and not receiving corticosteroids at Week 48.
- Phase 3: PRO-2 Remission at Week 48 [Week 48]
PRO-2 remission is defined based on average daily stool frequency (SF) and average daily abdominal pain (AP) score.
- Phase 3: Endoscopic Remission at Week 12 [Week 12]
Endoscopic remission is defined as SES-CD score <=2.
- Phase 3: Endoscopic Remission at Week 48 [Week 48]
Endoscopic remission is defined as SES-CD score <=2.
- Phase 3: Fatigue Response at Week 12 [Week 12]
Fatigue response will be based on the Patient-Reported Outcomes Measurement Information System (PROMIS). Fatigue Short Form 7a contains 7 items that evaluate the severity of fatigue, with higher scores indicating greater fatigue.
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Have Crohn's disease (CD) or fistulizing Crohn's disease of at least 3 months duration (defined as a minimum of 12 weeks), with colitis, ileitis, or ileocolitis, confirmed at any time in the past by radiography, histology, and/or endoscopy
-
Have moderate to severe CD as assessed by CDAI, stool frequency (SF), and abdominal pain (AP) scores, and Simple Endoscopic Score for Crohn's Disease (SES-CD)
-
Have screening laboratory test results within the protocol specified parameters
-
A female participant of childbearing potential must have a negative urine pregnancy test result at screening and baseline
-
Demonstrated intolerance or inadequate response to conventional or to biologic therapy for CD
Exclusion Criteria:
-
Current diagnosis of ulcerative colitis or indeterminate colitis
-
Has complications of Crohn's disease, such as symptomatic strictures or stenoses, short gut syndrome, or any other manifestation
-
Unstable doses of concomitant Crohn's disease therapy
-
Receipt of Crohn's disease approved biologic agents, investigational agents, or procedures outside of permitted timeframe as specified in the protocol
-
Prior exposure to p40 inhibitors or p19 inhibitors
-
Any medical contraindications preventing study participation
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Internal Medicine Center | Mobile | Alabama | United States | 36693 |
| 2 | Northport Medical Center | Northport | Alabama | United States | 35476 |
| 3 | Advanced Gastro P.C | Chandler | Arizona | United States | 85224 |
| 4 | University of Arizona | Tucson | Arizona | United States | 85724 |
| 5 | Moore Clinical Trials, LLC | Sherwood | Arkansas | United States | 72120 |
| 6 | Advanced Research Center Inc | Anaheim | California | United States | 92805 |
| 7 | Paul Wallace MD | Beverly Hills | California | United States | 90211 |
| 8 | Precision Research Institute | El Cajon | California | United States | 92020 |
| 9 | University Of California San Diego | La Jolla | California | United States | 92093 |
| 10 | Om Research LLC | Lancaster | California | United States | 93534 |
| 11 | UCLA | Los Angeles | California | United States | 90095 |
| 12 | UCI Irvine Medical Center | Orange | California | United States | 92868 |
| 13 | Inland Empire Liver Foundation | Rialto | California | United States | 91106 |
| 14 | UC Davis Medical Center | Sacramento | California | United States | 95817 |
| 15 | Northern California Research | Sacramento | California | United States | 95821 |
| 16 | Clinical Applications Laboratories, Inc | San Diego | California | United States | 91941 |
| 17 | Precision Research Institute | San Diego | California | United States | 92114 |
| 18 | Peak Gastroenterology Associates | Colorado Springs | Colorado | United States | 80920 |
| 19 | Yale University School Of Medicine | New Haven | Connecticut | United States | 06510 |
| 20 | MedStar Georgetown University Hospital | Washington | District of Columbia | United States | 20007 |
| 21 | Pioneer Research Solutions Inc. | Coconut Creek | Florida | United States | 33066 |
| 22 | InvesClinic, LLC | Fort Lauderdale | Florida | United States | 33308 |
| 23 | Harmony Medical Research Institute, Inc. | Hialeah | Florida | United States | 33016 |
| 24 | Elite Research Network - Nature Coast Clinical Research, LLC | Inverness | Florida | United States | 34452 |
| 25 | University of Florida | Jacksonville | Florida | United States | 32209 |
| 26 | SIH Research | Kissimmee | Florida | United States | 34759 |
| 27 | Auzmer Research | Lakeland | Florida | United States | 33813 |
| 28 | Homestead Associates in Research, Inc | Miami | Florida | United States | 33032 |
| 29 | Community Research Foundation, Inc. | Miami | Florida | United States | 33155 |
| 30 | Sanchez Clinical Research, Inc | Miami | Florida | United States | 33157-6575 |
| 31 | Visionary Investigators Network | Miami | Florida | United States | 33180 |
| 32 | Gastroenterology Group Of Naples | Naples | Florida | United States | 34102 |
| 33 | Ocala GI Research, LLC | Ocala | Florida | United States | 34471 |
| 34 | Florida Hospital | Orlando | Florida | United States | 32803 |
| 35 | Synexus Clinical Research US, Inc | Orlando | Florida | United States | 32806 |
| 36 | Combined Research Orlando | Orlando | Florida | United States | 32807 |
| 37 | Omega Research Consultants | Orlando | Florida | United States | 32808 |
| 38 | Care Access Research, Orlando | Orlando | Florida | United States | 32825 |
| 39 | Synexus Clinical Research US, Inc | Pinellas Park | Florida | United States | 33781 |
| 40 | Theia Clincial Research, LLC | Pinellas Park | Florida | United States | 33781 |
| 41 | Central Florida Internists | Saint Cloud | Florida | United States | 34769 |
| 42 | Synergy Clinical Research | Saint Petersburg | Florida | United States | 33705 |
| 43 | Clinical Research of West Florida | Tampa | Florida | United States | 33603 |
| 44 | GCP Clinical Research | Tampa | Florida | United States | 33609 |
| 45 | Florida Hospital Tampa | Tampa | Florida | United States | 33613 |
| 46 | Cleveland Clinic Florida | Weston | Florida | United States | 33331 |
| 47 | Morehouse School of Medicine | Atlanta | Georgia | United States | 30310 |
| 48 | Emory University | Atlanta | Georgia | United States | 30322 |
| 49 | Atlanta Gastroenterology Associates | Atlanta | Georgia | United States | 30342 |
| 50 | Atlanta Center For Gastroenterology | Decatur | Georgia | United States | 30033 |
| 51 | Gastrointestinal Specialists of Georgia | Marietta | Georgia | United States | 30060 |
| 52 | Gastroenterology Consultants | Roswell | Georgia | United States | 30076 |
| 53 | Atlanta Gastroenterology Specialists PC | Suwanee | Georgia | United States | 30024 |
| 54 | Northwestern University | Chicago | Illinois | United States | 60611 |
| 55 | Center for Gastrointestinal Health | Fairview Heights | Illinois | United States | 62208 |
| 56 | Carle Foundation Hospital | Urbana | Illinois | United States | 61801 |
| 57 | IU Health University Hospital | Indianapolis | Indiana | United States | 46202 |
| 58 | Health Science Research Center | Pratt | Kansas | United States | 67124 |
| 59 | Cotton O'Neil Digestive Health Center | Topeka | Kansas | United States | 66606 |
| 60 | Robley Rex VAMC | Louisville | Kentucky | United States | 40206 |
| 61 | Gastroenterology Associates | Baton Rouge | Louisiana | United States | 70809 |
| 62 | Gastroenterology Clinic of Acadiana | Lafayette | Louisiana | United States | 70503 |
| 63 | Gastroenterology Clinic of Acadiana | Lafayette | Louisiana | United States | 70503 |
| 64 | Tandem Clinical Research | Marrero | Louisiana | United States | 70072 |
| 65 | Ochsner Clinic Foundation | New Orleans | Louisiana | United States | 70121 |
| 66 | DelRicht Research | New Orleans | Louisiana | United States | 70124 |
| 67 | LSUHSC Shreveport Feist-Weiller Cancer Center | Shreveport | Louisiana | United States | 71103 |
| 68 | Louisiana Research Center, LLC | Shreveport | Louisiana | United States | 71105 |
| 69 | University of Maryland | Baltimore | Maryland | United States | 21201 |
| 70 | Woodholme Gastroenterology Associates | Baltimore | Maryland | United States | 21208 |
| 71 | Woodholme Gastroenterology Associates | Baltimore | Maryland | United States | 21208 |
| 72 | Harvard Medical School-Beth Israel Deaconess Medical Center | Boston | Massachusetts | United States | 02215 |
| 73 | Digestive Health Specialists PC | Chelmsford | Massachusetts | United States | 01824 |
| 74 | Umass Memorial Medical Center | Worcester | Massachusetts | United States | 01655 |
| 75 | Clinical Research Institute of Michigan, LLC | Chesterfield | Michigan | United States | 48047 |
| 76 | Associated cardiology | Saginaw | Michigan | United States | 48603 |
| 77 | Huron Gastroenterology Associates Center for Digestive Care | Ypsilanti | Michigan | United States | 48197 |
| 78 | Washington University | Saint Louis | Missouri | United States | 63110 |
| 79 | Sierra Clinical Research | Las Vegas | Nevada | United States | 89106 |
| 80 | Las Vegas Medical Research | Las Vegas | Nevada | United States | 89113 |
| 81 | Advanced Gastroenterology of Bergen County | Englewood Cliffs | New Jersey | United States | 07632 |
| 82 | Atlantic Digestive Health Institute/ Atlantic IBD Center | Morristown | New Jersey | United States | 07960 |
| 83 | Penn Medicine - Princeton Health | Plainsboro | New Jersey | United States | 08536 |
| 84 | Drug Trials America - Hartsdale | Hartsdale | New York | United States | 10530 |
| 85 | A1 Clinical Research | Jackson Heights | New York | United States | 11372 |
| 86 | Weill Cornell Medical College | New York | New York | United States | 10021 |
| 87 | Care Access Research | New York | New York | United States | 10065 |
| 88 | NYU Langone Long Island Clinical Research Associates | New York | New York | United States | 11021 |
| 89 | NYU Langone Medical Center | New York | New York | United States | 11021 |
| 90 | A 1 Clinical Network | Queens | New York | United States | 11375 |
| 91 | University of Rochester Medical Center | Rochester | New York | United States | 14642 |
| 92 | Syracuse VA Medical Center | Syracuse | New York | United States | 13210 |
| 93 | Mohawk Valley Endoscopy Center | Utica | New York | United States | 13502 |
| 94 | Asheville Gastroenterology Associates | Asheville | North Carolina | United States | 28801 |
| 95 | University North Carolina at Chapel Hill | Chapel Hill | North Carolina | United States | 27599 |
| 96 | Onsite Clinical Solutions | Charlotte | North Carolina | United States | 28277 |
| 97 | Cumberland Research Associates | Fayetteville | North Carolina | United States | 28304 |
| 98 | Carolina Research | Greenville | North Carolina | United States | 27834 |
| 99 | Care Access Research, Kinston | Kinston | North Carolina | United States | 28501 |
| 100 | Clinical Trials of America | Mount Airy | North Carolina | United States | 27030 |
| 101 | PMG Research of Winston-Salem | Winston-Salem | North Carolina | United States | 27103 |
| 102 | Clinical Inquest Center, LTD | Beavercreek | Ohio | United States | 45432 |
| 103 | Wexner Medical Center at the Ohio State University | Columbus | Ohio | United States | 43210 |
| 104 | Synexus Clinical Research US, Inc | Columbus | Ohio | United States | 43212 |
| 105 | Great Lakes Gastroenterology Research, LLC | Mentor | Ohio | United States | 44060 |
| 106 | Southwoods Health | Poland | Ohio | United States | 44514 |
| 107 | Digestive Specialists, Inc | Springboro | Ohio | United States | 45066 |
| 108 | Northshore Gastroenterology Research, LLC | Westlake | Ohio | United States | 44145 |
| 109 | Central Sooner Research | Norman | Oklahoma | United States | 73071 |
| 110 | Integris Baptist Office | Oklahoma City | Oklahoma | United States | 73112 |
| 111 | The Oregon Clinic | Portland | Oregon | United States | 97220 |
| 112 | Drexel University College of Medicine | Philadelphia | Pennsylvania | United States | 19107 |
| 113 | Allegheny-Singer Research Institute | Pittsburgh | Pennsylvania | United States | 15212-4756 |
| 114 | Guthrie Medical Group, PC | Sayre | Pennsylvania | United States | 18840 |
| 115 | Care Access Research | Scranton | Pennsylvania | United States | 18508 |
| 116 | Frontier Clinical Research | Smithfield | Pennsylvania | United States | 15478 |
| 117 | US Digestive Health | Wyomissing | Pennsylvania | United States | 19610 |
| 118 | LifeSpan Hospital System | Providence | Rhode Island | United States | 02903 |
| 119 | Synexus Clinical Research US, Inc | Anderson | South Carolina | United States | 29621-2062 |
| 120 | Clinical Trials of South Carolina | Charleston | South Carolina | United States | 29406 |
| 121 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 122 | Gastroenterology Associates P.A. | Greenville | South Carolina | United States | 29615 |
| 123 | Gastroenterology Associates of Orangeburg, SC | Orangeburg | South Carolina | United States | 29118 |
| 124 | AIG Research Services | Hermitage | Tennessee | United States | 37076 |
| 125 | Tennessee State University | Johnson | Tennessee | United States | 37614-1700 |
| 126 | Volunteer Research Group | Knoxville | Tennessee | United States | 37920 |
| 127 | Vanderbilt University Medical Center | Nashville | Tennessee | United States | 37212-1610 |
| 128 | Avant Research Associates, LLC | Austin | Texas | United States | 78704 |
| 129 | Aztec Clinical Research, Inc. | Channelview | Texas | United States | 77530 |
| 130 | Baylor College Of Medicine - Dept Of Dermatology | Houston | Texas | United States | 77030 |
| 131 | Baylor College of Medicine | Houston | Texas | United States | 77030 |
| 132 | Houston Methodist Hospital | Houston | Texas | United States | 77030 |
| 133 | Memorial Hermann Hospital - TMC | Houston | Texas | United States | 77030 |
| 134 | Biopharma Informatic Research Center | Houston | Texas | United States | 77043 |
| 135 | Houston Digestive Diseases Consultants | Houston | Texas | United States | 77074 |
| 136 | CliniCore Houston | Houston | Texas | United States | 77079 |
| 137 | BI Research Center | Houston | Texas | United States | 77084 |
| 138 | DHAT Research Institute | Richardson | Texas | United States | 75082 |
| 139 | Sun Research Institute | San Antonio | Texas | United States | 78215 |
| 140 | Gastroenterology Clinic Of San Antonio P A | San Antonio | Texas | United States | 78229 |
| 141 | Gastroenterology Research of America, LLC | San Antonio | Texas | United States | 78229 |
| 142 | UT Health Science Center at San Antonio | San Antonio | Texas | United States | 78229 |
| 143 | Texas Digestive Disease Consultants | Southlake | Texas | United States | 76092 |
| 144 | Baylor Scott & White Research Institute | Temple | Texas | United States | 76508 |
| 145 | Tyler Research Institute, LLC | Tyler | Texas | United States | 75701 |
| 146 | Victoria Gastroenterology | Victoria | Texas | United States | 77904 |
| 147 | Digestive Health Research of North Texas, LLC | Wichita Falls | Texas | United States | 76301 |
| 148 | Val Hansen | Bountiful | Utah | United States | 84010 |
| 149 | Care Access Research, Ogden | Ogden | Utah | United States | 84403 |
| 150 | University of Virginia | Charlottesville | Virginia | United States | 22908 |
| 151 | Gastroenterology Associates of Tidewater | Chesapeake | Virginia | United States | 23320 |
| 152 | Center for Gastrointestinal Health | Petersburg | Virginia | United States | 23805 |
| 153 | Clinical Research Partners, LLC | Richmond | Virginia | United States | 23236 |
| 154 | Gastroenterology Consultants of Southwest Virginia | Roanoke | Virginia | United States | 24014-1372 |
| 155 | Washington Gastroenterology, PLLC | Tacoma | Washington | United States | 98405 |
| 156 | Marshall Health Clinical Research Center | Huntington | West Virginia | United States | 25701 |
| 157 | Medical College of Wisconsin-Froedtert Hospital | Milwaukee | Wisconsin | United States | 53226 |
| 158 | The Queen Elizabeth Hospital | Adelaide | Australia | 5011 | |
| 159 | Monash Health, Monash Medical Centre | Clayton | Australia | 3168 | |
| 160 | Concord Hospital | Concord | Australia | 2139 | |
| 161 | Western Health | Footscray | Australia | 3011 | |
| 162 | Fremantle Hospital | Fremantle | Australia | 6160 | |
| 163 | Austin Hospital | Heidelberg | Australia | 3084 | |
| 164 | Royal Brisbane and Women's Hospital | Herston | Australia | 4029 | |
| 165 | Sir Charles Gairdner Hospital | Nedlands | Australia | 6009 | |
| 166 | Coral Sea Clinical Research Institute | North Mackay | Australia | 4740 | |
| 167 | Royal Adelaide Hospital | North Terrace | Australia | 5000 | |
| 168 | Royal Melbourne Hospital | Parkville | Australia | 3050 | |
| 169 | Nepean Hospital | Penrith | Australia | 2751 | |
| 170 | The Alfred Hospital | Prahran | Australia | 3004 | |
| 171 | Mater Hospital Brisbane | South Brisbane | Australia | 4101 | |
| 172 | Princess Alexandra Hospital | Woolloongabba | Australia | 4102 | |
| 173 | Medizinische Universität Innsbruck | Innsbruck | Austria | 6020 | |
| 174 | Krankenhaus der Elisabethinen Linz | Linz | Austria | A-4020 | |
| 175 | Universitätsklinikum Salzburg - Landeskrankenhaus | Salzburg | Austria | 5020 | |
| 176 | Akh Wien | Wien | Austria | 1090 | |
| 177 | Gomel Regional Clinical Hospital | Gomel | Belarus | 246029 | |
| 178 | Republican Research Centre of Radiation Medicine and Human E | Gomel | Belarus | 246040 | |
| 179 | Grodno University Hospital | Grodno | Belarus | 230017 | |
| 180 | BelMAPE | Minsk | Belarus | 220014 | |
| 181 | City Clinical Hospital #9 | Minsk | Belarus | 220116 | |
| 182 | Vitebsk Regional Clinical Hospital | Vitebsk | Belarus | 210037 | |
| 183 | GZA Ziekenhuizen | Antwerpen | Belgium | 2018 | |
| 184 | AZ Klina | Brasschaat | Belgium | 2930 | |
| 185 | CHU Saint-Pierre | Bruxelles | Belgium | 1000 | |
| 186 | Hopital Erasme | Bruxelles | Belgium | 1070 | |
| 187 | AZ Maria Middelares | Gent | Belgium | 9000 | |
| 188 | UZ Gent | Gent | Belgium | 9000 | |
| 189 | Az Groeninge | Kortrijk | Belgium | 8500 | |
| 190 | Centre Hospitalier De Mouscron | Mouscron | Belgium | 7700 | |
| 191 | Algemeen Ziekenhuis Delta | Roeselare | Belgium | 8800 | |
| 192 | CHwapi | Tournai | Belgium | 7500 | |
| 193 | University Clinical Centre of the Republic of Srpska | Banja Luka | Bosnia and Herzegovina | 78000 | |
| 194 | Clinical hospital Mostar | Mostar | Bosnia and Herzegovina | 88000 | |
| 195 | Clinical Center University of Sarajevo | Sarajevo | Bosnia and Herzegovina | 71000 | |
| 196 | Polyclinic Dr. Al-Tawil | Sarajevo | Bosnia and Herzegovina | 71000 | |
| 197 | Kantonalna bolnica Zenica | Zenica | Bosnia and Herzegovina | 72000 | |
| 198 | MK Blumenau Pesquisa Clínica | Blumenau | Brazil | 89010-506 | |
| 199 | Universidade Estadual Paulista 'Julio De Mesquita Filho' | Botucatu | Brazil | 18618-970 | |
| 200 | Hospital Brasa-lia | Brasa-lia | Brazil | 71635-200 | |
| 201 | L2IP - Instituto de Pesquisas Clínicas | Brasília | Brazil | 70200-730 | |
| 202 | Hospital e Maternidade Celso Pierro | Campinas | Brazil | 13590-900 | |
| 203 | Fundação Universidade de Caxias do Sul | Caxias Do Sul | Brazil | 95070-560 | |
| 204 | Universidade Católica do Paraná PUCPR | Curitiba | Brazil | 80215-901 | |
| 205 | Centro Digestivo de Curitiba - Instituto de Pesquisa Clínica | Curitiba | Brazil | 80430-180 | |
| 206 | Hospital Nossa Senhora Das Gracas | Curitiba | Brazil | 80810-040 | |
| 207 | Instituto Goiano de Gastroenterologia e Endoscopia Digestiva | Goiania | Brazil | 74535-170 | |
| 208 | Hospital Universitrio Santa Terezinha | Joaaba | Brazil | 89600-000 | |
| 209 | CMIP-Centro Mineiro de Pesquisa | Juiz de Fora | Brazil | 36010-570 | |
| 210 | Liga Norte Riograndense Contra O Cancer | Natal | Brazil | 59062000 | |
| 211 | Complexo Hospitalar de Niterói | Niterói | Brazil | 24020-096 | |
| 212 | Instituto Mederi de Pesquisa e Saude | Passo Fundo | Brazil | 99010-120 | |
| 213 | Irmandade Santa Casa de Misericordia de Porto Alegre | Porto Alegre | Brazil | 90020-090 | |
| 214 | Hospital de Clínicas de Porto Alegre/ HCPA / UFRGS | Porto Alegre | Brazil | 90035-903 | |
| 215 | Hospital Ernesto Dornelles | Porto Alegre | Brazil | 90160-093 | |
| 216 | Instituto do Aparelho Digestivo | Porto Alegre | Brazil | 90560-002 | |
| 217 | Hospital da Crianca Santo Antonio de Porto Alegre | Porto Alegre | Brazil | 92020-430 | |
| 218 | UFRJ-Hospital Universitário Clementino Fraga Filho | Rio de Janeiro | Brazil | 21941-913 | |
| 219 | Bioclinica Inc. Research Network | Rio de Janeiro | Brazil | 22271-100 | |
| 220 | Hospital Santa Izabel | Salvador | Brazil | 40050-410 | |
| 221 | Universidade Federal da Bahia (UFBA) - Complexo Hospitalar U | Salvador | Brazil | 40110-060 | |
| 222 | Pesquisare Saude | Santo Andre | Brazil | 09080-110 | |
| 223 | Praxis pesquisa médica | Santo André | Brazil | 09090-790 | |
| 224 | CEMEC - Centro Multidisciplinar de Estudos Clínicos | Santo André | Brazil | 09190-510 | |
| 225 | Irmandade da Santa Casa da Misericórdia de Santos | Santos São Paulo | Brazil | 11075-101 | |
| 226 | Fundacao Faculdade Regional De Medicina De Sao Jose Do Rio Preto | Sao Jose do Rio Preto | Brazil | 15090-000 | |
| 227 | Hemomed | Sao Paulo | Brazil | 01236-030 | |
| 228 | Hospital do Servidor Publico Estadual - IAMSPE | Sao Paulo | Brazil | 04039-901 | |
| 229 | Hepatogastro | Sao Paulo | Brazil | 04543-011 | |
| 230 | Hospital Santa Paula | Sao Paulo | Brazil | 04556-100 | |
| 231 | CEP - Hospital das Clinicas da FMUSP | Sao Paulo | Brazil | 05403000 | |
| 232 | Centro de Estudos Clínicos do Interior Paulista - CECIP | Sao Paulo | Brazil | 17201-130 | |
| 233 | Kaiser Hospta | São José Do Rio Preto | Brazil | 15015-110 | |
| 234 | CPCLIN - Centro de Pesquisas Clínicas | São Paulo | Brazil | 01228-200 | |
| 235 | BR Trials | São Paulo | Brazil | 03325-050 | |
| 236 | HCFMUSP | São Paulo | Brazil | 05403000 | |
| 237 | Hospital Israelita Albert Einstein | São Paulo | Brazil | 05652-900 | |
| 238 | Universidade Federal Do Piaui - Campos Universitario | Teresina | Brazil | 64049-550 | |
| 239 | University of Calgary | Calgary | Alberta | Canada | T2N4Z6 |
| 240 | Gastroenterology and Internal Medicine Research Institute (GIRI) | Edmonton | Alberta | Canada | T5R 1W2 |
| 241 | Columbia Gastroenterology | New Westminster | British Columbia | Canada | |
| 242 | The Medical Arts Health Research Group | Vancouver | British Columbia | Canada | V7M 2H4 |
| 243 | PerCuro Clinical Research Ltd. | Victoria | British Columbia | Canada | V8V 3M9 |
| 244 | Health Sciences Centre | Winnipeg | Manitoba | Canada | R3A1R9 |
| 245 | QEII Health Sciences Centre | Helifax | Nova Scotia | Canada | B3H 2Y9 |
| 246 | Barrie GI Associates | Barrie | Ontario | Canada | L4M 7G1 |
| 247 | London Health Sciences Centre | London | Ontario | Canada | N6A 5A5 |
| 248 | Ottawa Hospital | Ottawa | Ontario | Canada | K1H 8L6 |
| 249 | Mount Sinai Hospital-Toronto | Toronto | Ontario | Canada | M5G 1X5 |
| 250 | Toronto Digestive Disease Associates Inc | Vaughan | Ontario | Canada | L4L 4Y7 |
| 251 | Hotel Dieu de Levis | Levis | Quebec | Canada | G6V 3Z1 |
| 252 | MUHC Center for Applied Ethics | Montreal | Quebec | Canada | H3H2R9 |
| 253 | Royal University Hospital | Saskatoon | Saskatchewan | Canada | S7N 0W8 |
| 254 | Viable Clinical Research | Dartmouth | Canada | B2W 6L4 | |
| 255 | GI Research Institute (G.I.R.I.) | Edmonton | Canada | T5H4B9 | |
| 256 | University of Alberta- Ziedler Ledcor Centre | Edmonton | Canada | T6G 2X8 | |
| 257 | Pharmaceutical Integrated Research Company | Waterloo | Canada | N2J 1C4 | |
| 258 | Instituto Oncologico Viña del Mar | Viña del Mar | Chile | 2540364 | |
| 259 | Peking University First Hospital | Beijing | China | 100034 | |
| 260 | Peking University People's Hospital | Beijing | China | 100044 | |
| 261 | Beijing Friendship Hospital | Beijing | China | 100050 | |
| 262 | Peking University Third Hospital | Beijing | China | 100191 | |
| 263 | The Military General Hospital of Beijing PLA | Beijing | China | 100700 | |
| 264 | China-Japan Union Hospital of Jilin University | Changchun | China | 130033 | |
| 265 | The second Xiangya Hospital of Central South University | Changsha | China | 200120 | |
| 266 | Xiangya Hospital Central South University | Changsha | China | 410008 | |
| 267 | Changzhou No.2 People's Hospital | Changzhou City | China | 213004 | |
| 268 | The First People's Hospital Of Changzhou | Changzhou | China | 213003 | |
| 269 | West China Hospital, Sichuan University | Chengdu | China | 610041 | |
| 270 | The Second Affiliated Hospital of Chongqing Medical University | Chongqing | China | 400010 | |
| 271 | Third Military Medical University Daping Hospital Cancer Center | Chongqing | China | ||
| 272 | First Affiliated Hospital of Gannan Medical University | Ganzhou | China | 341000 | |
| 273 | The First Affiliated Hospital Sun Yat-Sen University | Guangzhou | China | 510080 | |
| 274 | Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University | Guangzhou | China | 510235 | |
| 275 | ZhuJiang Hospital of Southern Medical University | Guangzhou | China | 510280 | |
| 276 | Sun Yat-sen University - The Sixth Affiliated Hospital Guangdong Gastrointestinal Hospital | Guangzhou | China | 510610 | |
| 277 | The Second Affiliated Hospital of Zhejiang University | Hangzhou | China | 310003 | |
| 278 | Sir Run Run Shaw Hospital, Zhejiang University School of Medicine | Hangzhou | China | 310016 | |
| 279 | The 1st affiliated hospital of Anhui Medical University | Hefei | China | 230022 | |
| 280 | Huai'an 1st Hospital | Huai'an | China | ||
| 281 | First Affiliated Hospital of Kunming Medical Unversity | Kunming | China | 650032 | |
| 282 | The First Affiliated Hospital of NanChang University | Nanchang | China | 330006 | |
| 283 | Nanjing Drum Tower Hospital | Nanjing | China | 210008 | |
| 284 | Zhongda Hospital,Southeast University | Nanjing | China | 210009 | |
| 285 | Jiangsu Province Hospital | Nanjing | China | 210029 | |
| 286 | Shanghai Ninth People's Hospital | Shanghai | China | 200011 | |
| 287 | Huashan Hospital Fudan University | Shanghai | China | 200040 | |
| 288 | Shanghai 10th Peoples Hospital | Shanghai | China | 200072 | |
| 289 | Shanghai General Hospital | Shanghai | China | 200080 | |
| 290 | Shanghai East Hospital | Shanghai | China | 200120 | |
| 291 | Shanghai Renji Hospital | Shanghai | China | 200127 | |
| 292 | Second Military Medical University (SMMU) | Shanghai | China | 200433 | |
| 293 | Tongji Hospital of Tongji University | Shanghai | China | 430030 | |
| 294 | Ruijin Hospital, Shanghai Jiao Tong University | Shanghai | China | ||
| 295 | The first hospital of China medical university | Shenyang | China | 110001 | |
| 296 | Shengjing Hospital of China Medical University | Shenyang | China | 110004 | |
| 297 | Peking University Shenzhen Hospital | Shenzhen | China | 518036 | |
| 298 | University of Hong Kong-Shenzhen Hospital | Shenzhen | China | 518053 | |
| 299 | The first affiliated hospital of suzhou University | Suzhou | China | ||
| 300 | Shaanxi Provincial People's Hospital | Taiyuan | China | 30002 | |
| 301 | Tianjin Medical University General Hospital | Tianjin | China | 300011 | |
| 302 | The First Affiliated Hospital of Wenzhou Medical University | Wenzhou | China | 325003 | |
| 303 | Wuhan Union Hospital | Wuhan | China | 430022 | |
| 304 | Renmin Hospital of Wuhan University | Wuhan | China | 430060 | |
| 305 | Wuxi People's Hospital | Wuxi | China | 214023 | |
| 306 | Zhongshan Hospital, Xiamen University | Xiamen | China | 361004 | |
| 307 | Yangzhou First People's Hospital | Yangzhou | China | 225001 | |
| 308 | Zhangzhou Municipal Hospital of Fujian Province | Zhangzhou | China | 363000 | |
| 309 | Medplus Medicina Prepagada S.A. | Bogota | Colombia | 110111 | |
| 310 | Clinica de la Mujer | Bogota | Colombia | 110221 | |
| 311 | Endocare Ltda. | Bogota | Colombia | 111111 | |
| 312 | Fundacion Santa Fe de Bogota | Bogotá D.C | Colombia | ||
| 313 | Hospital San Ignacio de la Universidad Javeria | Bogotá Na | Colombia | ||
| 314 | Centro Médico Imbanaco | Cali | Colombia | 760042 | |
| 315 | Corporacion para Estudios en Salud Clinica CES - Gastroenterology | Medellin | Colombia | 50012 | |
| 316 | Instituto De Coloproctologia Ico S.A.S | Medellin | Colombia | ||
| 317 | Opca bolnica Bjelovar | Bjelovar | Croatia | 43000 | |
| 318 | Klinički bolnički centar Osijek | Osijek | Croatia | 31000 | |
| 319 | University Hospital Center Split | Split | Croatia | 21000 | |
| 320 | Opca bolnica Zadar | Zadar | Croatia | 23000 | |
| 321 | CH Sestre Milosrdnice | Zagreb | Croatia | 10000 | |
| 322 | Poliklinika Solmed | Zagreb | Croatia | 10000 | |
| 323 | University Hospital Center Zagreb | Zagreb | Croatia | 10000 | |
| 324 | University Hospital Dubrava | Zagreb | Croatia | 10000 | |
| 325 | Nemocnice Ceske Budejovice | Ceske Budejovice | Czechia | 370 01 | |
| 326 | NH Hospital, a.s. | Horovice | Czechia | 268 31 | |
| 327 | FN Hradec Kralove | Hradec Kralove | Czechia | 500 05 | |
| 328 | Hepato-gastroenterologie HK, s.r.o. | Hradec Kralove | Czechia | 500 12 | |
| 329 | Fakultni nemocnice Ostrava | Ostrava - Poruba | Czechia | 70852 | |
| 330 | Synexus Czech s.r.o. | Prague 2 | Czechia | 120 00 | |
| 331 | Fakultni nemocnice Kralovske Vinohrady | Praha 10 | Czechia | 100 34 | |
| 332 | Klinicke centrum ISCARE | Praha 7 | Czechia | 170 00 | |
| 333 | CHU Amiens | Amiens | France | 80054 | |
| 334 | Centre Hospitalier de la Cote Basque | Bayonne | France | 64100 | |
| 335 | Hôpital Besançon | Besançon | France | 25030 | |
| 336 | Centre Hospitalier Universitaire (CHU) de Caen | Caen | France | 14033 | |
| 337 | CHRU de Tours - Hopital Trousseau | Chambray Les Tours Centre | France | 37170 | |
| 338 | CHU Clermont-Ferrant-Hopital Hotel Dieu | Clermont-Ferrand Cedex 3 | France | 63000 | |
| 339 | Hopitaux Universitaires Paris Nord Val de Seine - Hopital Beaujon | Clichy-Sous-Bois | France | 92110 | |
| 340 | Hôpital Beaujon | Clichy | France | 92110 | |
| 341 | Hopital Louis Mourier | Colombes Cedex | France | 92701 | |
| 342 | Centre Hospitalier Universitaire(CHU) - Hopital Henri Mondor | Créteil | France | 94010 | |
| 343 | CHU Grenoble | Grenoble | France | 38700 | |
| 344 | CHRU de Lille - Hôpital Claude Huriez | Lille | France | 59037 | |
| 345 | Aphm - Hopital Nord | Marseille | France | 13015 | |
| 346 | APHM Hopital Timone | Marseille | France | 13385 | |
| 347 | CHRU Montpellier - Hopital Saint-Eloi | Montpellier Cedex 5 | France | 34295 | |
| 348 | CHU de Nantes hôtel-Dieu | Nantes | France | 44093 | |
| 349 | CHU de Nice Hopital de l Archet | Nice cedex 03 | France | 06202 | |
| 350 | CHU Nimes - Hôpital Carémeau | Nimes | France | 30029 | |
| 351 | CHU Hôpital Saint Antoine | Paris cedex 12 | France | 75571 | |
| 352 | Hôpital Saint Louis | Paris | France | 75475 | |
| 353 | Groupement Hospitalier Universitaire Ouest | Paris | France | 75908 | |
| 354 | Centre Hospitalier Lyon Sud | Pierre-Bénite | France | 69495 | |
| 355 | Hôpital Robert Debré | Reims, Cedex | France | 51092 | |
| 356 | CHU Saint-etienne | Saint Etienne | France | 42055 | |
| 357 | Hopital D'Instruction Des Armees | Saint Mandé | France | 94160 | |
| 358 | Hôpitaux Universitaires de Strasbourg - Hôpital de Hautepierre | Strasbourg Cedex | France | 67098 | |
| 359 | CHU Rangueil | Toulouse | France | 31059 | |
| 360 | Hopital Purpan | Toulouse | France | 31059 | |
| 361 | CHU de Nancy_ Hôpital Brabois | Vandoeuvre-les-Nancy | France | 54511 | |
| 362 | LTD 'Aversi Clinic' | T'bilisi | Georgia | 0160 | |
| 363 | TSMU The First University Clinic | Tbilisi | Georgia | 0141 | |
| 364 | Institute of Clinical Cardiology, Ltd. | Tbilisi | Georgia | 0159 | |
| 365 | LTD 'Georgia Archangel St. Michael Multiprofile Clinical Hospital' | Tbilisi | Georgia | 0159 | |
| 366 | Ltd Central University Clinic by Academician N.Kipshidze | Tbilisi | Georgia | 0160 | |
| 367 | Ltd Medison Holding | Tbilisi | Georgia | 0186 | |
| 368 | Israel Georgian medical research clinic Helsicore | Tbilisi | Georgia | 112 | |
| 369 | LTD Unimed Kakheti- Telavi Referral Hospital | Telavi | Georgia | 2200 | |
| 370 | Klinikum Augsburg | Augsburg | Germany | D-86158 | |
| 371 | Gastroenterologische Spezialpraxis - Berlin-Karlshorst | Berlin-Karlshorst | Germany | 10318 | |
| 372 | Charité - Campus Mitte | Berlin | Germany | 10117 | |
| 373 | Synexus Berlin Research Center | Berlin | Germany | 12627 | |
| 374 | Universitaetsklinikum Charite, Campus Virchow Klinikum | Berlin | Germany | 13353 | |
| 375 | Vivantes Klinikum Spandau | Berlin | Germany | 13585 | |
| 376 | Krankenhaus Waldfriede Mitte | Berlin | Germany | 14163 | |
| 377 | Universitatsklinikum Bonn | Bonn | Germany | 53105 | |
| 378 | Klinikum Dresden | Dresden | Germany | 1307 | |
| 379 | Florence Nightingale Krankenhaus | Düsseldorf | Germany | 40489 | |
| 380 | Agaplesion Frankfurter Diakonie Kliniken GmbH, Markus Krankenhaus | Frankfurt/Main | Germany | 60431 | |
| 381 | Synexus Clinical Research GmbH | Frankfurt | Germany | 60313 | |
| 382 | JWG-University Hospital | Frankfurt | Germany | 69590 | |
| 383 | Martin-Luther-Universitaet Halle-Wittenberg - Universitaetsk | Halle | Germany | 06120 | |
| 384 | BSF Studiengesellschaft | Halle | Germany | 6108 | |
| 385 | Martini-Klinik am Universitätsklinikum Hamburg-Eppendorf Urologie | Hamburg | Germany | 20246 | |
| 386 | Asklepios Westklinikum | Hamburg | Germany | 22559 | |
| 387 | Medizinische Hochschule Hannover | Hannover | Germany | 30625 | |
| 388 | Universitaetsklinikum Heidelberg | Heidelberg | Germany | 69120 | |
| 389 | Universitatsklinikum Schleswig-Holstein - Kiel | Kiel | Germany | 24105 | |
| 390 | Eugastro GmbH | Leipzig | Germany | 04103 | |
| 391 | Gastroenterologie und Hepatologie am Johannisplatz | Leipzig | Germany | 04103 | |
| 392 | Städtisches Klinikum Lüneburg | Lueneburg | Germany | 21339 | |
| 393 | Universitätsklinikum Schleswig-Holstein | Lübeck | Germany | 23538 | |
| 394 | Universitatsklinikum Mannheim | Mannheim | Germany | 68167 | |
| 395 | Klinik für Innere Medizin II | München | Germany | 81675 | |
| 396 | Gemeinschaftspraxis Germania-Campus | Münster | Germany | 48159 | |
| 397 | Praxiszentrum Alte Mälzerei | Regensburg | Germany | 93053 | |
| 398 | Magen Darm Zentrum | Remscheid | Germany | 42859 | |
| 399 | Zentrum für Gastroenterologie Saar MVZ GmbH | Saarbrücken | Germany | 66111 | |
| 400 | Universitätsklinikum Ulm | Ulm | Germany | 89081 | |
| 401 | Sotiria General State Hospital of Chest Diseases | Athens | Greece | 115 27 | |
| 402 | Laiko General Hospital of Athens | Athens | Greece | 11527 | |
| 403 | Hippokration Hospital | Athens | Greece | 11528 | |
| 404 | University Hospital of Heraklion | Heraklion | Greece | 71110 | |
| 405 | University General Hospital of Ioannina | Ioannina | Greece | 45100 | |
| 406 | Euromedica General Clinic | Thessaloniki | Greece | 54645 | |
| 407 | Obudai Egeszsegugyi Centrum Kft. | Budapest | Hungary | 1036 | |
| 408 | Synexus Magyarorszag Kft. | Budapest | Hungary | 1036 | |
| 409 | Péterfy Sándor utcai Kórház | Budapest | Hungary | 1076 | |
| 410 | Észak-Közép-budai Centrum, Új Szent János Kórház és Szakrendelő Budai Családközpontú | Budapest | Hungary | 1125 | |
| 411 | Meddica Centre Hungarian Defence Froces | Budapest | Hungary | H-1062 | |
| 412 | Semmelweis Egyetem | Budapest | Hungary | H-1088 | |
| 413 | Réthy Pál Kórház - Rendelőintézet | Békéscsaba | Hungary | 5600 | |
| 414 | Synexus Magyarorszag Kft | Gyula | Hungary | 5700 | |
| 415 | Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz | Gyula | Hungary | 5701 | |
| 416 | Kaposi Mór Oktató Kórház, Kardiológiai Részleg | Kaposvár | Hungary | 7400 | |
| 417 | Karolina Hospital | Mosonmagyarovár | Hungary | H-9200 | |
| 418 | Szegedi Tud.Egyetem Szent-Gyorgyi Albert Klin. Közp. | Szeged | Hungary | 6720 | |
| 419 | Tolna Megyei Balassa János Kórház | Szekszárd | Hungary | 7100 | |
| 420 | Kaizen Hospital | Ahmedabad | India | 380052 | |
| 421 | M S Ramaiah Medical College and Hospital | Bangalore | India | 560054 | |
| 422 | S.P.Medical College & AG of Hospitals | Bikaner | India | 334003 | |
| 423 | SIMS Multispecialty Hospital | Chennai | India | 600026 | |
| 424 | Citizen Hospital | Hyderabad | India | 500019 | |
| 425 | Asian Institute Of Gastroenterology | Hyderabad | India | 500082 | |
| 426 | SMS Hospital | Jaipur | India | 302004 | |
| 427 | Dr. Nijhawan's Clinic | Jaipur | India | 302017 | |
| 428 | Chhatrapati Shahuji Maharaj Medical University | Lucknow | India | 226003 | |
| 429 | Baba Farid University of Health Sciences - Christian Medical | Ludhiana | India | 141008 | |
| 430 | Chopda Medicare & Research Centre Pvt.Ltd, Magnum Heart Institute | Nashik | India | 422005 | |
| 431 | All India Institute of Medical Sciences | New Delhi | India | 110029 | |
| 432 | Sir Ganga Ram Hospital | New Delhi | India | 110060 | |
| 433 | Fortis Hospital | Noida | India | 201301 | |
| 434 | Indira Gandhi Institute of Medical Sciences | Patna | India | 800014 | |
| 435 | Nirmal Hospital Pvt. Ltd. | Surat | India | 395002 | |
| 436 | Surat Institute of Digestive Sciences Hospitals | Surat | India | 395002 | |
| 437 | BAPS Pramukhswami Hospital | Surat | India | 395009 | |
| 438 | Unity Hospital | Surat | India | 395010 | |
| 439 | Osmania General Hospital | Telangana | India | 500012 | |
| 440 | Samvedana Hospital | Varanasi | India | 221005 | |
| 441 | Andhra Hospitals | Vijayawada | India | 520 002 | |
| 442 | Government Siddhartha Medical College | Vijayawada | India | 520008 | |
| 443 | Ha'Emek Medical Center | Afula | Israel | 1834111 | |
| 444 | Barzilai Medical Center | Ashkelon | Israel | 78278 | |
| 445 | Soroka Medical Center | Bear Sheva | Israel | 84100 | |
| 446 | Hillel Yaffe Medical Center | Hadera | Israel | 38100 | |
| 447 | Rambam Medical Center | Haifa | Israel | 31096 | |
| 448 | Bnai Zion Medical Center | Haifa | Israel | 3339419 | |
| 449 | Shaare Zedek Medical Center | Jerusalem | Israel | 9103102 | |
| 450 | Hadassah Hebrew University Medical Center | Jerusalem | Israel | 91120 | |
| 451 | Hadassah Medical Organization Ein Kerem | Jerusalem | Israel | 91120 | |
| 452 | Meir Medical Center | Kfar Saba | Israel | 4428164 | |
| 453 | Galilee Medical Center | Nahariya | Israel | 2210001 | |
| 454 | Rabin Med Ctr Beilinson Hosp | Petah Tikva | Israel | 4941492 | |
| 455 | Chaim Sheba Medical Center | Ramat Gan | Israel | 5262000 | |
| 456 | Tel Aviv Sourasky Medical Center | Tel Aviv | Israel | 6423906 | |
| 457 | Assaf Harofeh Medical Center | Zerifin | Israel | 70300 | |
| 458 | Policlinico S.Orsola Malpighi, AOU di Bologna | Bologna | Italy | 40138 | |
| 459 | Azienda Ospedaliero Universitaria di Cagliari - Policlinico Duilio Casula di Monserrato | Cagliari | Italy | 09042 | |
| 460 | Azienda Ospedaliera G. Brotzu | Cagliari | Italy | 09134 | |
| 461 | A.O. Per L' Emergenza Cannizzaro - U.O. Chirurgia Generale | Catania | Italy | 95126 | |
| 462 | Ospedale Santissima Annunziata | Cento | Italy | 44042 | |
| 463 | AOU Careggi | Firenze | Italy | 50134 | |
| 464 | AOU Policlinico G.Martino | Messina | Italy | 98125 | |
| 465 | Gruppo Ospedaliero San Donato - Istituto di Ricovero e Cura | Milano | Italy | 20097 | |
| 466 | IRCCS Ospedale San Raffaele | Milano | Italy | 20132 | |
| 467 | AOU Policlinico di Modena | Modena | Italy | 41124 | |
| 468 | Universita degli Studi di Padova - Azienda Ospedaliera di Padova | Padova | Italy | 35128 | |
| 469 | Università Campus Biomedico di Roma | Roma | Italy | 00128 | |
| 470 | IBD Unit- Sandro Pertini Hospital | Roma | Italy | 00157 | |
| 471 | Catholic University of Sacred Hearth | Roma | Italy | 00168 | |
| 472 | Complesso Integrato Columbus | Rome | Italy | 00168 | |
| 473 | Istituto Clinico Humanitas Rozzano, IRCCS | Rozzano | Italy | 20089 | |
| 474 | Casa Sollievo della Sofferenza | San Giovanni Rotondo | Italy | 71013 | |
| 475 | Ospedale Molinette, AO Città della Salute e della Scienza di | Torino | Italy | 10126 | |
| 476 | S.C. Gastroenterologia | Torino | Italy | 10128 | |
| 477 | Azienda Ospedaliero Universitaria S.Maria Della Misericordia | Udine | Italy | 33100 | |
| 478 | Policlinico G.B.Rossi | Verona | Italy | 37134 | |
| 479 | Asahikawa City Hospital | Asahikawa | Japan | 070-8610 | |
| 480 | Juntendo University Hospital | Bunkyo-ku | Japan | 113-8431 | |
| 481 | Chiba University Hospital | Chiba | Japan | 260-8677 | |
| 482 | Fukuoka University Chikushi Hospital | Chikushino | Japan | 818-8502 | |
| 483 | Saiseikai Fukuoka General Hospital | Fukuoka-shi | Japan | 810-0001 | |
| 484 | Fukuoka University Hospital | Fukuoka-shi | Japan | 814-0180 | |
| 485 | Gifu University Hospital | Gifu | Japan | 501-1194 | |
| 486 | Matsuda Hospital | Hamamatsu-shi | Japan | 432-8061 | |
| 487 | National Hospital Organization Mito Medical Center | Higashiibaraki-gun | Japan | 311-3193 | |
| 488 | Hirosaki National Hospital | Hirosaki | Japan | 036-8545 | |
| 489 | Hiroshima University Hospital | Hiroshima | Japan | 734-8551 | |
| 490 | Tokai University Hospital | Isehara | Japan | 259-1193 | |
| 491 | Izumiotsu Municipal Hospital | Izumiotsu | Japan | 595-0027 | |
| 492 | Shimane University Hospital | Izumo | Japan | 693-8501 | |
| 493 | Kagoshima IBD Gastroenterology Clinic | Kagoshima | Japan | 892-0843 | |
| 494 | Sameshima Hospital | Kagoshima | Japan | 892-0846 | |
| 495 | Nanpuh Hospital | Kagoshima | Japan | 892-8512 | |
| 496 | Kanazawa University Hospital | Kanazawa | Japan | 9208651 | |
| 497 | Nara Medical University Hospital | Kashihara | Japan | 634-8522 | |
| 498 | Tsujinaka Hospital Kashiwanoha | Kashiwa | Japan | 277-0871 | |
| 499 | The Jikei University Hospital | Kashiwa | Japan | 277-8567 | |
| 500 | Aoyama Naika Clinic | Kobe | Japan | 650-0015 | |
| 501 | Kobe University Hospital | Kobe | Japan | 650-0017 | |
| 502 | National Hospital Organization Kochi National Hospital | Kochi | Japan | 780-8077 | |
| 503 | Yamanashi Prefectural Central Hospital | Kofu | Japan | 400-8506 | |
| 504 | Showa University Kouto Toyosu Hospital | Koto-ku | Japan | 135-8577 | |
| 505 | National Hospital Organization Kure Medical Center and Chugoku Cancer Center | Kure | Japan | 736-0023 | |
| 506 | Kurume University Hospital | Kurume | Japan | 830-0011 | |
| 507 | University Hospital Kyoto Perfectural University of Medicine | Kyoto | Japan | 602-8566 | |
| 508 | JRC Kyoto Daiichi Hospital | Kyoto | Japan | 605-0981 | |
| 509 | Kyoto University Hospital | Kyoto | Japan | 606-8507 | |
| 510 | National Hospital Organization Kyoto Medical Center | Kyoto | Japan | 612-8555 | |
| 511 | Kitasato University Kitasato Institute Hospital | Minato-ku | Japan | 108-8642 | |
| 512 | Kyorin University Hospital | Mitaka | Japan | 181-8611 | |
| 513 | Osaki Citizen Hospital | Miyagi | Japan | 989-6183 | |
| 514 | Iwate Medical University Hospital | Morioka | Japan | 020-8505 | |
| 515 | Aichi Medical University Hospital | Nagakute | Japan | 480-1195 | |
| 516 | Nagaoka Red Cross Hospital | Nagaoka | Japan | 940-2085 | |
| 517 | Nagasaki University Hospital | Nagasaki | Japan | 852-8501 | |
| 518 | Nagoya University Hospital | Nagoya | Japan | 466-8560 | |
| 519 | Nagoya City University Hospital | Nagoya | Japan | 467-8602 | |
| 520 | Niigata University Medical & Dental Hospital | Niigata | Japan | 951-8520 | |
| 521 | The Hospital of Hyogo College of Medicine | Nishinomiya | Japan | 663-8501 | |
| 522 | JA Obihiro Kosei Hospital | Obihiro | Japan | 080-0024 | |
| 523 | Oita Red Cross Hospital | Oita | Japan | 870-0033 | |
| 524 | Okayama Saiseikai General Hospital | Okayama | Japan | 700-8511 | |
| 525 | Keiaikai Chibana Clinic | Okinawa | Japan | 904-2143 | |
| 526 | Kindai University Hospital | Osaka-Sayama | Japan | 589-8511 | |
| 527 | National Hospital Organization Osaka National Hospital | Osaka-shi | Japan | 540-0006 | |
| 528 | Kinshukai Infusion Clinic | Osaka | Japan | 530-0011 | |
| 529 | Kitano Hospital | Osaka | Japan | 530-8480 | |
| 530 | Japanese Red Cross Osaka Hospital | Osaka | Japan | 543-8555 | |
| 531 | Osaka City University Hospital | Osaka | Japan | 545-8586 | |
| 532 | National Hospital Organization Higashi Ohmi General Medical Center | Otsu-shi | Japan | 527-8505 | |
| 533 | Shiga University of Medical Science Hospital | Otsu | Japan | 520-2192 | |
| 534 | Japan Community Health Care Organization Saitama Medical Center | Saitama | Japan | 330-0074 | |
| 535 | Tokitokai Tokito Clinic Coloproctology Center | Saitama | Japan | 336-0963 | |
| 536 | Saitama Medical University Hospital | Saitama | Japan | 350-0495 | |
| 537 | Toho University Sakura Medical Center | Sakura | Japan | 285-8741 | |
| 538 | Sapporo IBD Clinic | Sapporo Chuo-ku | Japan | 064-0919 | |
| 539 | Hokkaido University Hospital | Sapporo-shi | Japan | 060-8648 | |
| 540 | Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital | Sapporo | Japan | 060-0033 | |
| 541 | Sapporo Higashi Tokushukai Hospital | Sapporo | Japan | 065-0033 | |
| 542 | Keio University Hospital | Shinjuku-ku | Japan | 160-8582 | |
| 543 | Tokyo Yamate Medical Center | Shinjuku-ku | Japan | 169-0073 | |
| 544 | Osaka University Hospital | Suita-shi | Japan | 565-0871 | |
| 545 | Takamatsu Red Cross Hospital | Takamatsu | Japan | 760-0017 | |
| 546 | Kagawa Prefectural Central Hospital | Takamatsu | Japan | 760-8557 | |
| 547 | Tokushima University Hospital | Tokushima | Japan | 770-8503 | |
| 548 | The Jikei University Hospital | Tokyo | Japan | 105-8471 | |
| 549 | Yuaikai Tomishiro Central Hospital | Tomishiro | Japan | 901-0243 | |
| 550 | Ehime University Hospital | Toon | Japan | 791-0295 | |
| 551 | Toyama City Hospital | Toyama-shi | Japan | 939-8511 | |
| 552 | Fujita Health University Hospital | Toyoake | Japan | 470-1192 | |
| 553 | Mie University Hospital | Tsu | Japan | 514-8507 | |
| 554 | Wakayama Medical University Hospital | Wakayama | Japan | 641-8509 | |
| 555 | Yokohama City University Medical Center | Yokohama | Japan | 232-0024 | |
| 556 | Khalidi Hospital and Medical Center | Amman | Jordan | 11183 | |
| 557 | Istishari Hospital | Amman | Jordan | 11184 | |
| 558 | Prince Hamza Hospital | Amman | Jordan | 11731 | |
| 559 | Jordan University Hospital | Amman | Jordan | 11942 | |
| 560 | Irbid Specialty Hospital | Irbid | Jordan | 21110 | |
| 561 | King Abdullah University Hospital | Irbid | Jordan | 22110 | |
| 562 | Korea University Ansan Hospital | Ansan-si | Korea, Republic of | 15355 | |
| 563 | Inje University Haeundae Paik Hospital | Busan | Korea, Republic of | 48108 | |
| 564 | Kosin University Gospel Hospital | Busan | Korea, Republic of | 602-702 | |
| 565 | Dong-A University Hospital | Busan | Korea, Republic of | 602-812 | |
| 566 | Kyongpook national university Medical center | Daegu | Korea, Republic of | 41404 | |
| 567 | Kyungpook National University Hospital | Daegu | Korea, Republic of | 41944 | |
| 568 | Hallym University Dongtan Sacred Heart Hospital | Hwaseong-si | Korea, Republic of | 18450 | |
| 569 | Seoul National University Bundang Hospital | Seongnam-si | Korea, Republic of | 13620 | |
| 570 | CHA Bundang Medical Center, CHA University | Seongnam | Korea, Republic of | 13496 | |
| 571 | The Catholic Univ. of Korea, DaeJeon St. Mary's Hospital | Seongnam | Korea, Republic of | 13620 | |
| 572 | Kyung Hee University Medical Center | Seoul | Korea, Republic of | 02447 | |
| 573 | Kangbuk Samsung Hospital | Seoul | Korea, Republic of | 03181 | |
| 574 | Yonsei University College of Medicine | Seoul | Korea, Republic of | 03722 | |
| 575 | Asan Medical Center | Seoul | Korea, Republic of | 05505 | |
| 576 | Samsung Medical Center | Seoul | Korea, Republic of | 06351 | |
| 577 | Gangnam Severance Hospital | Seoul | Korea, Republic of | 135-720 | |
| 578 | The Catholic University of Korea, Seoul St.Mary's Hospital | Seoul | Korea, Republic of | 6591 | |
| 579 | Chung-Ang University Hospital | Seoul | Korea, Republic of | 6973 | |
| 580 | The Catholic University of Korea St. Vincent's Hospital | Suwon-si | Korea, Republic of | 16247 | |
| 581 | Ewha Womans University Mokdong Hospital | YangCheon-Gu | Korea, Republic of | 07985 | |
| 582 | Pauls Stradins Clinical University Hospital | Riga | Latvia | LV-1002 | |
| 583 | Riga East Clinical University Hospital | Riga | Latvia | LV-1038 | |
| 584 | Alda Pukisa arsta prakse | Riga | Latvia | LV-1046 | |
| 585 | Ain Wazein Hospital | Ain Wazein | Lebanon | ||
| 586 | American Universitty of Beirut Medical Center | Beirut | Lebanon | 110 72020 | |
| 587 | St Georges Hospital university medical centre | Beirut | Lebanon | 166378 | |
| 588 | Hotel Dieu de France Hospital | Beirut | Lebanon | 166830 | |
| 589 | Bellevue Medical Center | Beirut | Lebanon | ||
| 590 | Mount Lebanon Hospital | Beirut | Lebanon | ||
| 591 | Rafik Hariri University Hospital | Beirut | Lebanon | ||
| 592 | Notre Dame De Secours | Jbeil | Lebanon | ||
| 593 | Hammoud Hospital | Saida | Lebanon | ||
| 594 | Nini Hospital | Tripoli | Lebanon | NAP | |
| 595 | Lietuvos sveikatos mokslų universiteto ligoninė Kauno klinik | Kaunas | Lithuania | LT-50009 | |
| 596 | Vilnius University Hospital Santaros Klinikos, Public Institution | Vilnius | Lithuania | LT-08661 | |
| 597 | Hospital Ampang | Ampang | Malaysia | 68000 | |
| 598 | Hospital Raja Permaisuri Bainun | Ipoh | Malaysia | 30990 | |
| 599 | Hospital Sultanah Aminah | Johor Bahru | Malaysia | 80100 | |
| 600 | Hospital Raja Perempuan Zainab Ii | Kota Bahru | Malaysia | 15160 | |
| 601 | Hospital Kuala Lumpur | Kuala Lumpur | Malaysia | 50586 | |
| 602 | University Malaya Medical Centre | Kuala Lumpur | Malaysia | 59120 | |
| 603 | Hospital Tengku Ampuan Afzan | Kuantan | Malaysia | 25100 | |
| 604 | Onze Lieve Vrouwe Gasthuis | Amsterdam | Netherlands | 1091 AC | |
| 605 | Academisch Medisch Centrum Universiteit van Amsterdam | Amsterdam | Netherlands | 1105 AZ | |
| 606 | Rijnstate | Arnhem | Netherlands | 6815 AD | |
| 607 | Leiden University Medical Center | Leiden | Netherlands | 2333 ZA | |
| 608 | Academisch Ziekenhuis Maastricht | Maastricht | Netherlands | 6229 HX | |
| 609 | Stichting Zuyderland Medisch Centrum | Sittard-Geleen | Netherlands | 6130 MB | |
| 610 | UMC Utrecht | Utrecht | Netherlands | 3584 CX | |
| 611 | Auckland City Hospital | Auckland | New Zealand | 1142 | |
| 612 | Christchurch Hospital | Christchurch | New Zealand | 8140 | |
| 613 | Dunedin Hospital | Dunedin | New Zealand | 9016 | |
| 614 | Waikato Hospital | Hamilton | New Zealand | 3204 | |
| 615 | Hutt Hospital | Lower Hutt | New Zealand | 5010 | |
| 616 | General City Hospital 8mi Septemvri | Skopje | North Macedonia | 1000 | |
| 617 | University Clinic of Gastroenterohepatology | Skopje | North Macedonia | 1000 | |
| 618 | Alesund sjukehus | Alesund | Norway | 6010 | |
| 619 | Oslo Universitetssykehus HF | Oslo | Norway | N-0514 | |
| 620 | NZOZ Centrum Medyczne KERmed | Bydgoszcz | Poland | 85-681 | |
| 621 | Centrum Medyczne Lukamed | Chojnice | Poland | 89-600 | |
| 622 | Synexus Polska Sp. z o.o. Oddzial w Czestochowie | Czestochowa | Poland | 42-202 | |
| 623 | Synexus Polska Sp. z o.o. Oddzial w Gdansku | Gdansk | Poland | 80-382 | |
| 624 | Synexus Scm Sp. Z o.o. Oddzial Gdynia | Gdynia | Poland | 81-537 | |
| 625 | Prywatna Praktyka Lekarska | Jelenia Góra | Poland | 8-500 | |
| 626 | Synexus Polska Sp. z o.o. Oddzial w Katowicach | Katowice | Poland | 40-040 | |
| 627 | VITA LONGA Sp. z o.o. | Katowice | Poland | 40-748 | |
| 628 | MZ Badania Slowik Zymla Spolka jawna | Knurow | Poland | 44-190 | |
| 629 | Malopolskie Centrum Kliniczne | Krakow | Poland | 30-149 | |
| 630 | Centrum medyczne plejady | Krakow | Poland | 30-363 | |
| 631 | Centrum Medyczne Pratia Krakow | Krakow | Poland | 31-002 | |
| 632 | Centrum Medyczne Promed | Krakow | Poland | 31-513 | |
| 633 | Centrum Opieki Zdrowotnej Orkan-med Stec-Michalska sj | Ksawerów | Poland | 95-054 | |
| 634 | Synexus Polska Sp. z o.o. | Lodz | Poland | 90-127 | |
| 635 | AmiCare Centrum Medyczne | Lodz | Poland | 90-644 | |
| 636 | 1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ w Lublinie | Lublin | Poland | 20-049 | |
| 637 | Gastromed Spotka Z Ograniczona Odpowiedzialnoscia Sp. K. | Lublin | Poland | 20-582 | |
| 638 | Wojewodzki Szpital Specjalistyczny w Olsztynie | Olsztyn | Poland | 10-561 | |
| 639 | Twoja Przychodnia | Opole | Poland | 45-819 | |
| 640 | Oswiecimskie Centrum Badan Klinicznych | Oswiecim | Poland | 32-600 | |
| 641 | EMC Instytut Medyczny SA | Poznan | Poland | 60-309 | |
| 642 | Solumed S.C. | Poznan | Poland | 60-529 | |
| 643 | Synexus Polska Sp. z.o.o. Oddzial w Poznaniu | Poznan | Poland | 60-702 | |
| 644 | Twoja Przychodnia | Poznan | Poland | 61-293 | |
| 645 | KO-MED Centra Kliniczne Sp. z o.o. | Pulawy | Poland | 24-100 | |
| 646 | Centrum Medyczne 'Medyk' Sp. z o.o. K. | Rzeszow | Poland | 35-055 | |
| 647 | Endoskopia Sp z o.o. | Sopot | Poland | 81-756 | |
| 648 | Kiepury Clinic | Sosnowiec | Poland | 41-209 | |
| 649 | Twoja Przychodnia - Szczecinskie Centrum Medyczne | Szczecin | Poland | 71-270 | |
| 650 | Niepubliczny Zaklad Opieki Zdrowotnej | Szczecin | Poland | 71-685 | |
| 651 | Toruńskie Centrum Gastrologiczne | Toruń | Poland | 87-100 | |
| 652 | H-T Centrum Medyczne Endoterapia | Tychy | Poland | 43-100 | |
| 653 | NZOZ Vivamed Zespol Lekarzy Specjalistow | Warsaw | Poland | 03-580 | |
| 654 | Wojskowy Instytut Medyczny | Warszawa | Poland | 00-141 | |
| 655 | Centrum Medyczne Pratia Warszawa | Warszawa | Poland | 01-868 | |
| 656 | Centralny Szpital Kliniczny MSWiA w Warszawie | Warszawa | Poland | 02-507 | |
| 657 | Centrum Medyczne | Warszawa | Poland | 02-676 | |
| 658 | Centrum Badawcze Wspolczesnej Terapii | Warszawa | Poland | 02-679 | |
| 659 | Szpital Pomnik Centrum Zdrowia Dziecka | Warszawa | Poland | 04-730 | |
| 660 | Synexus Polska Sp. z o.o. Oddzial w Warszawie | Warszawa | Poland | 623832 | |
| 661 | Centrum Zdrowia Tuchow | Wierzchoslawice | Poland | 33-122 | |
| 662 | Centrum Diagnostyczno - Lecznicze Barska sp. z o.o. Szpital Specjalistyczny Barska | Wloclawek | Poland | 87-800 | |
| 663 | Futuremeds sp. z o.o. | Wroclaw | Poland | 50-088 | |
| 664 | Melita Medical Sp. z o.o. | Wroclaw | Poland | 50-449 | |
| 665 | Przychodnia Vistamed | Wroclaw | Poland | 53-149 | |
| 666 | ARS MEDICA Rybak Maria, Rybak Zbigniew, s.c. | Wroclaw | Poland | 53-333 | |
| 667 | EuroMediCare Szpital Specjalistyczny z Przychodnia | Wroclaw | Poland | 54-144 | |
| 668 | Synexus Polska Sp. z o.o. Oddzial we Wroclawiu | Wrocław | Poland | 50-381 | |
| 669 | ETG Zamosc | Zamosc | Poland | 22-400 | |
| 670 | Hospital de Braga | Braga | Portugal | 4710-243 | |
| 671 | Centro Hospitalar e Universitário de Coimbra, EPE | Coimbra | Portugal | 3000-075 | |
| 672 | Hosp. Sra. Da Oliveira - Guimaraes | Guimarães | Portugal | 4835-044 | |
| 673 | Centro Hospitalar Lisboa Norte, EPE/Hosp. Santa Maria | Lisboa | Portugal | 1649-035 | |
| 674 | Centro Hospitalar Lisboa Norte EPE - Hospital Pulido Valente | Lisbon | Portugal | 2720-276 | |
| 675 | Hospital Beatriz Angelo | Loures | Portugal | 2674-514 | |
| 676 | Hospital de Portimao-Centro Hospitalar do Barlavento Algarvio | Portimao | Portugal | 8500-338 | |
| 677 | H. Santo António - Centro Hospitalar do Porto | Porto | Portugal | 4099-001 | |
| 678 | Centro Hospitalar de Entre o Douro e Vouga, E.P.E | Santa Maria da Feira | Portugal | 4520-211 | |
| 679 | Centro Hospitalar de Tondela Viseu, EPE | Viseu | Portugal | 3504-509 | |
| 680 | San Juan Bautista School of Medicine | Caguas | Puerto Rico | 00726 | |
| 681 | Hopital San Cristobal | Ponce | Puerto Rico | 00795 | |
| 682 | VA Caribbean Healthcare System - San Juan VA Medical Center | San Juan | Puerto Rico | 00921-3201 | |
| 683 | Medical Center Meditsinskie Tekhnologii | Ekaterinburg | Russian Federation | 620075 | |
| 684 | Medical Association 'New Hospital' | Ekaterinburg | Russian Federation | 620109 | |
| 685 | LLC Aliance Biomedical-Ural group | Izhevsk | Russian Federation | 426077 | |
| 686 | Immanuel Kant Baltic Federal University | Kaliningrad | Russian Federation | 236016 | |
| 687 | Kazan State Medical University | Kazan | Russian Federation | 420012 | |
| 688 | Research Medical Center Your Health | Kazan | Russian Federation | 420103 | |
| 689 | Kemerovo Region Clinical Hospital | Kemerovo | Russian Federation | 650066 | |
| 690 | Kuban State Medical Academy | Krasnodar | Russian Federation | 350086 | |
| 691 | KGBUZ 'Regional Clinical Hospital' | Krasnoyarsk | Russian Federation | 660022 | |
| 692 | Clinical-Diagnostic Center Euromedservice, JSC | Moscow | Russian Federation | 115419 | |
| 693 | State Scientific Centre of Coloproctology | Moscow | Russian Federation | 123423 | |
| 694 | State Scientific Centre of Coloproctology | Moscow | Russian Federation | 123423 | |
| 695 | City Hospital #13 of Avtozavodsky | Nizhniy Novgorod | Russian Federation | 603018 | |
| 696 | Novgorod Regional Clinical Hospital n.a. N.A. Semashko | Nizhny Novgorod | Russian Federation | 603126 | |
| 697 | Novosibirsk Region Clinical Hospital | Novosibirsk | Russian Federation | 630087 | |
| 698 | City Clinical Hospital #12 | Novosibirsk | Russian Federation | 630091 | |
| 699 | Federal State Budgetary Institution 'Scientific Research In | Novosibirsk | Russian Federation | 630117 | |
| 700 | FSBI 'Scientific Research Institute of Clinical and Experimental Lymphology' of Siberian Branch | Novosibirsk | Russian Federation | 630117 | |
| 701 | Clinical Diagnostic Center 'Ultramed' | Omsk | Russian Federation | 644024 | |
| 702 | Perm Clinical Center of the Federal Medical and Biological Agency | Perm | Russian Federation | 614109 | |
| 703 | Republican Hospital n.a.V.A.Baranov | Petrozavodsk | Russian Federation | 185019 | |
| 704 | GBUZ of Moscow Region City Clinical Hospital #3 | Podolsk | Russian Federation | 142105 | |
| 705 | GBOU VPO Rostov State Medical University | Rostov-na-Donu | Russian Federation | 344022 | |
| 706 | City Hospital #20 | Rostov-on-Don | Russian Federation | 344091 | |
| 707 | Medical Technologies Limited Company | Saint Petersburg | Russian Federation | 191025 | |
| 708 | International Medical Centre SOGAZ | Saint Petersburg | Russian Federation | 191186 | |
| 709 | Clinical Hospital #122 n.a. after L.G. Sokolov | Saint Petersburg | Russian Federation | 194291 | |
| 710 | City Hospital #9 | Saint Petersburg | Russian Federation | 197110 | |
| 711 | City Hospital named after St. Martyr Elizabeth | Saint-Petersburg | Russian Federation | 195257 | |
| 712 | City Clinical Hospital # 26 | Saint-Petersburg | Russian Federation | 196247 | |
| 713 | Medical University Reaviz | Samara | Russian Federation | 443001 | |
| 714 | NUZ 'Railway Clinical Hospital on Samara station of LLC 'Russian Railways' | Samara | Russian Federation | 443041 | |
| 715 | Northen-Western State Medical University n.a. I.I. Mechnikov | Sankt-Peterburg | Russian Federation | 195067 | |
| 716 | Saratov City Hospital #5 | Saratov | Russian Federation | 410071 | |
| 717 | City Hospital# 40 | Sestroretsk | Russian Federation | 197706 | |
| 718 | St.Petersburg State Medical University n.a.Pavlov | St Petersburg | Russian Federation | 197022 | |
| 719 | City Clinical Hospital #31 | St. Petersburg | Russian Federation | 197110 | |
| 720 | LLC PoliClinic EXPERT | St. Petersburg | Russian Federation | 197110 | |
| 721 | LLC PoliClinic EXPERT | St. Petersburg | Russian Federation | 197110 | |
| 722 | Tomsk Regional Clinical Hospital | Tomsk | Russian Federation | 634063 | |
| 723 | Consultative and Diagnostic Center 'Endos' | Tyumen | Russian Federation | 625026 | |
| 724 | Ulyanovsk Regional Clinical Hospital | Ulyanovsk | Russian Federation | 432063 | |
| 725 | GUZ Novgorod Regional Clinical Hospital | Velikiy Novgorod | Russian Federation | 173008 | |
| 726 | King Fahad Specialist hospital | Dammam | Saudi Arabia | 31444 | |
| 727 | King Abdullah Medical City in Holy Capital | Makkah | Saudi Arabia | 21955 | |
| 728 | King Abdul Aziz Medical City for National Guard Health Affairs | Riyadh | Saudi Arabia | 11426 | |
| 729 | King Khalid Hospital | Riyadh | Saudi Arabia | 12372 | |
| 730 | Special hospital for Internal diseases, Oncomed system | Belgrade | Serbia | 11000 | |
| 731 | University Clinical Center of Serbia | Belgrade | Serbia | 11000 | |
| 732 | Zvezdara University Medical Center | Belgrade | Serbia | 11000 | |
| 733 | Clinical Hospital Center Bezanijska Kosa | Belgrade | Serbia | 11080 | |
| 734 | University Clinical Center Kragujevac | Kragujevac | Serbia | 34000 | |
| 735 | General Hospital 'Djordje Joanovic' | Zrenjanin | Serbia | 23000 | |
| 736 | FNsP F.D.R. Banska Bystrica | Banska Bystrica | Slovakia | 975 17 | |
| 737 | ENDOMED s.r.o | Kosice | Slovakia | 040 13 | |
| 738 | Fakultna nemocnica Nitra | Nitra | Slovakia | 950 01 | |
| 739 | GASTRO I. s.r.o. | Presov | Slovakia | 080 01 | |
| 740 | Hosp. Reina Sofia | Córdoba | Spain | 14004 | |
| 741 | Complejo Hosp Univ. de Ferrol | Ferrol | Spain | 15405 | |
| 742 | Hosp. Univ. Fuenlabrada | Fuenlabrada | Spain | 28942 | |
| 743 | Hosp. Univ. Dr. Josep Trueta | Girona | Spain | 17007 | |
| 744 | Hosp. Gral. Juan Ramon Jimenez | Huelva | Spain | 21005 | |
| 745 | Hosp. Gral. Univ. Gregorio Marañon | Madrid | Spain | 28007 | |
| 746 | Hosp. Univ. Ramon Y Cajal | Madrid | Spain | 28034 | |
| 747 | Hosp. Clinico San Carlos | Madrid | Spain | 28040 | |
| 748 | Hosp. Univ. La Paz | Madrid | Spain | 28046 | |
| 749 | Hosp. Univ. Pta. de Hierro Majadahonda | Majadahonda | Spain | 28222 | |
| 750 | Hosp. Univ. Central de Asturias | Oviedo | Spain | 33011 | |
| 751 | Hosp. Provincial de Pontevedra | Pontevedra | Spain | 36071 | |
| 752 | Hosp. Clinico Univ. de Salamanca | Salamanca | Spain | 37007 | |
| 753 | Hosp. Virgen Del Rocio | Sevilla | Spain | 41013 | |
| 754 | Hosp. Ntra. Sra. de Valme | Sevilla | Spain | 41014 | |
| 755 | Hosp. Univ. de Torrejon | Torrejón de Ardoz | Spain | 28850 | |
| 756 | Hosp. Alvaro Cunqueiro | Vigo | Spain | 36312 | |
| 757 | Hosp. Univ. Miguel Servet | Zaragoza | Spain | 50009 | |
| 758 | Linkoping University Hospital | Linkoping | Sweden | 58185 | |
| 759 | Ersta sjukhus | Stockholm | Sweden | 116 91 | |
| 760 | Gastromottagningen | Stockholm | Sweden | 18288 | |
| 761 | Gastroenterologische Praxis Balsiger und Seibold | Bern | Switzerland | 3012 | |
| 762 | Chang-Hua Christian Hospital | Changhua | Taiwan | 500 | |
| 763 | China Medical University Hospital | Taichung | Taiwan | 40447 | |
| 764 | National Taiwan University Hospital | Taipei | Taiwan | 10002 | |
| 765 | Chang-Gung Memorial Hospital-Linkou | Taoyuan | Taiwan | 33305 | |
| 766 | Hopital Regional Mohamed Tahar El Maamouri | Nabul | Tunisia | 8000 | |
| 767 | Hopital Universitaire Sahloul | Sousse | Tunisia | 4051 | |
| 768 | Hospital La Rabta | Tunis Jebbari | Tunisia | 1007 | |
| 769 | Hopital Habib Thameur | Tunis | Tunisia | 1008 | |
| 770 | Military Hospital of Instruction of Tunis | Tunis | Tunisia | ||
| 771 | Cukurova University Medical Faculty Balcali Hospital | Adana | Turkey | 00133 | |
| 772 | Hacettepe University Medical Faculty | Ankara | Turkey | 06100 | |
| 773 | Gazi University Hospital | Ankara | Turkey | 06560 | |
| 774 | Gulhane Egitim ve Arastirma Hastanesi | Ankara | Turkey | 6010 | |
| 775 | Ankara University Medical Faculty | Ankara | Turkey | 6100 | |
| 776 | Acibadem Fulya Hospital | D:14/4 Nisantasi | Turkey | 34340 | |
| 777 | Firat University Hospital | Elazig | Turkey | 23200 | |
| 778 | Gaziantep University School of Medicine | Gaziantep | Turkey | 27310 | |
| 779 | Mustafa Kemal University Research and Practise Hospital | Hatay | Turkey | 31001 | |
| 780 | Bezmialem University Medical Faculty | İstanbul | Turkey | 34093 | |
| 781 | Istanbul University Istanbul Medical Faculty | Istanbul | Turkey | 34093 | |
| 782 | Sisli Etfal Egitim ve Arastirma Hospital | Istanbul | Turkey | 34360 | |
| 783 | Marmara University Medical Faculty | Istanbul | Turkey | 34899 | |
| 784 | Ege Universitesi Tip Fakultesi | Izmir | Turkey | 35040 | |
| 785 | Dokuz Eylul Universitesi Tip Fakultesi | Izmir | Turkey | 35210 | |
| 786 | Istanbul Medeniyet University Goztepe Training and Research Hospital | Kadikoy | Turkey | 34722 | |
| 787 | Kocaeli University Medical Faculty | Kocaeli | Turkey | 41380 | |
| 788 | Inonu Universitesi Turgut Ozal Tip Merkezi, Ic Hastaliklari | Malatya | Turkey | 44280 | |
| 789 | Mersin University Medical Faculty Hospital | Mersin | Turkey | 33110 | |
| 790 | Mersin University Medical Faculty | Mersin | Turkey | 33343 | |
| 791 | Karadeniz Teknik University Medical Faculty | Trabzon | Turkey | 61080 | |
| 792 | Zonguldak Bulent Ecevit University Medical Faculty | Zonguldak | Turkey | 97000 | |
| 793 | Dnipropetrovska oblasna klinichna likarnia im. I.I. Mechnikova | Dnipropetrovsk | Ukraine | 49005 | |
| 794 | Ivano-Frankivsk Regional Clinical Hospital | Ivano-Frankivsk | Ukraine | 76014 | |
| 795 | MNCE'City Clinical Hospital №2 named after prof. O.O. Shalimov' of the Kharkiv City Council | Kharkiv | Ukraine | 61037 | |
| 796 | SE 'National institute therapy named L.T. Maloi NAMS of Ukraine' | Kharkiv | Ukraine | 61039 | |
| 797 | KZ Khersonska Miska Klinichna Likarnia Im. Ye.Ie.Karabelesha | Kherson | Ukraine | 73000 | |
| 798 | Treatment and Diagnostic Center of LLC MRT Elit | Kropyvnytskyi | Ukraine | 25005 | |
| 799 | O.O.Bogomolets National Medical University, Kyiv City Clinical Hospital #18, | Kyiv | Ukraine | 01030 | |
| 800 | LLC Treatment and Diagnostic Center Adonis Plus | Kyiv | Ukraine | 02002 | |
| 801 | Medical Center 'Ok Clinic' of LLC 'International Institute of Clinical Studies' | Kyiv | Ukraine | 02091 | |
| 802 | Medical Research and Practice Center Medbud of the Public Joint Stock Holding Company Kyivmiskbud | Kyiv | Ukraine | 03037 | |
| 803 | Kyiv Railway Clinical Hospital #2 Of Branch 'Health Center' Of The Company 'Ukrainian Railway' | Kyiv | Ukraine | 03049 | |
| 804 | CI of Kyiv RC Kyiv Regional Clinical Hospital | Kyiv | Ukraine | 04053 | |
| 805 | Kyiv Regional Clinical Hospital | Kyiv | Ukraine | 4107 | |
| 806 | Lviv National Medical University | Lviv | Ukraine | 79010 | |
| 807 | Communal Nonprofit Enterprise Clinical Hospital of Emergency Hospital of Lviv | Lviv | Ukraine | 79059 | |
| 808 | Odesa City Hospital # 3 | Odesa | Ukraine | 65014 | |
| 809 | Odeska oblasna klinichna likarnia | Odesa | Ukraine | 65025 | |
| 810 | Sumska oblasna klinichna likarnia | Sumy | Ukraine | 40022 | |
| 811 | Ternopil municipal hospital #1 | Ternopil | Ukraine | 46000 | |
| 812 | MNCE Zakarpatska Regional Clinical Hospital named after A Novak of Zakarpatska Regional Council | Uzhgorod | Ukraine | 88000 | |
| 813 | Private Small Enterprise Medical Center Pulse | Vinnytsia | Ukraine | 21001 | |
| 814 | Health Clinic Limited Liability Company | Vinnytsia | Ukraine | 21009 | |
| 815 | Komunalna ustanova 'Miska likarnia №1' | Zaporizhzhia | Ukraine | 69104 | |
| 816 | Zaporizka oblasna klinichna likarnia | Zaporizhzhia | Ukraine | 69600 | |
| 817 | KU 6 miska klinichna likarnia ZMR | Zaporozhye | Ukraine | 69035 | |
| 818 | Barnsley District General Hospital | Barnsley | United Kingdom | S75 2EP | |
| 819 | Royal Victoria Hospital | Belfast | United Kingdom | BT12 6BA | |
| 820 | South Eastern Health and Social Care Trust | Belfast | United Kingdom | BT16 1RH | |
| 821 | Airedale General Hospital | Bradford | United Kingdom | BD20 6TD | |
| 822 | Addenbrooke's Hospital | Cambridge | United Kingdom | CB2 0QQ | |
| 823 | Leighton Hospital | Crewe | United Kingdom | CW1 4QJ | |
| 824 | Queen Elizabeth University Hospital | Glasgow | United Kingdom | G51 4TF | |
| 825 | St. Mark's Hospital | Harrow | United Kingdom | HA1 3UJ | |
| 826 | Egin Research | High Wycombe | United Kingdom | HP112QW | |
| 827 | Whipps Cross University Hospital | London | United Kingdom | E111NR | |
| 828 | St George's Healthcare NHS Trust | London | United Kingdom | SW17 0QT | |
| 829 | Nottingham University Hospitals NHS Trust | Nottingham | United Kingdom | NG7 2UH | |
| 830 | Sandwell and West Birmingham Hospitals NHS Trust-Sandwell Gene | West Bromwich | United Kingdom | B71 4HJ | |
| 831 | New Cross Hospital | Wolverhampton | United Kingdom | WV10 0QP |
Sponsors and Collaborators
- Janssen Research & Development, LLC
Investigators
- Study Director: Janssen Research & Development, LLC Clinical Trial, Janssen Research & Development, LLC
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Janssen Research & Development, LLC
ClinicalTrials.gov Identifier:
NCT03466411
Other Study ID Numbers:
- CR108387
- 2017-002195-13
- CNTO1959CRD3001
First Posted:
Mar 15, 2018
Last Update Posted:
Apr 28, 2022
Last Verified:
Apr 1, 2022
Studies a U.S. FDA-regulated Drug Product:
Yes
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms: