Short to Long Effects of Whole Body Cryostimulation on Insulin Sensitivity Among Overweight
Study Details
Study Description
Brief Summary
Therapeutic effectiveness of coldness in relieving pain and reducing inflammation has been known for many years now. Over that time, various coldness therapies have gained in popularity, including winter swimming, snow baths or whole body cryostimulation (WBC) . Recent researches have shown positive effects of WBC on metabolic profile, low-to-moderate chronic inflammation and related diseases (e.g., obesity). WBC could be, thus, intended as an adjuvant method in the treatment of dysmetabolic conditions, such as overweight or obesity. WBC is a cheap easily accessible practice, with a few well-defined contraindications and limited non severe possible adverse events, if performed in specialized centres. At the same time, in sport science appears data, which indicated on inhibition of adaptive changes induced by regular training.
The primary aim is to define, through a randomized controlled approach, the relative effectiveness of up to 20 consecutive sessions of either WBC, high-intensity intermittent training (HIIT), or their combination (WBC and HIIT) in improving the metabolic status of overweight and obese subjects. The effects will be assessed, at different time-points, in terms of insulin sensitivity and modification in the profile of hormones regulating the energy metabolism (adipokines, myokines, bone-derived hormones) and the inter-organ cross-talk.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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N/A |
Detailed Description
Secondary aims are:
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To assess the influence of WBC and HIIT on insulin sensitivity and establish the role of myokines (irisin and IL-6) in this regulation. To find the answer for the question if the rise of mentioned myokines cause a decrease of authophagy protein HMGB1.
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To characterize potential effectiveness of these intervention protocols on bone and energy metabolisms by stimulating in vitro cultured normal human osteoblastic primary cells and β-pancreatic cells with sera obtained from patients at different time points during treatment.
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To establish, which procedure is most effective at improving insulin sensitivity: training or training supported with WBC treatment, which factors modify this response (body composition or physical capacity of subjects)
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To establish if training supported with WBC treatment impairs adaptive changes of trained subjects
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To determine the potential beneficial effects of the intervention protocols on the metabolic homeostasis, and assess how long these changes are maintained over a period of four weeks or three months.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: whole body cryostimulation treatment WBC will be performed at the Pomeranian Rheumatologic Centre in Sopot. The centre is equipped with an electric cryochamber Zimmer Medicine System, Cryochamber ELECPOL, located in a temperature- and humidity-controlled room. The patient, minimally dressed (e.g., bathing suit, socks, clogs, headband, and surgical mask), remains 30sec at -60°C (vestibule) for body adaptation and, then, passes to the cryochamber, at -110°C and stay there 3 minutes. |
Other: whole body cryostimulation treatment
The WBC is apporved by National Ministry of Health. It uses cryochamber with low temperature -110 oC. The patient, minimally dressed (e.g., bathing suit, socks, clogs, headband, and surgical mask), remains 30sec at -60°C (vestibule) for body adaptation and, then, passes to the cryochamber, at -110°C and stay there 3 minutes.
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| Experimental: Connection WBC treatment and HIIT training This group will perform HIIT protocol and WBC sessions . HIIT will be performed after 1h WBC. |
Other: Connection WBC treatment and HIIT training
WBC combination with Exercise HIIT according to Litlle protocol from 2011. This exercise protocol will be applied together with cryo-sessions
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| Active Comparator: Control Group Control group who will be investigated (meanwhile at baseline and after the interventions) |
Other: Control Group
This group willnot to change their daily habits . The measurements will be taken at baseline and at the end of the study
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| Experimental: HIIT training group This group will perform only HIIT protocol without cryo-sessions |
Other: HIIT training group
This group will do the training program without cold exposure
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Outcome Measures
Primary Outcome Measures
- The assessment of pro- and anti-inflammatory proteins concentration in blood , in response to applied procedures. [one month]
Proinflammatory: HMGB1 ng/ml, CRP ng/ml TNFalpha pg/ml Anti-inflammaotry: Irisin ng/ml Adiponectin ng/ml Leptin ng/lm IL-10 pg/ml
Secondary Outcome Measures
- Assessment of insulin sensitivity and insulin resistance [one month]
Measurement of fasting glucose and after oral glucose test concentration: glucose mg/ml insulin ng/ml, calculating Matsuda and HOMA indicators based on glucose and insulin concentrations
Other Outcome Measures
- Expresion of proteins induced by serum collected from our subjects [3 months]
Human osteoblasts and β-pancreatic cell line will be treated by serum, which comes from our participants
- Body composition assessment [one month]
assessment of weight [kg], skeletal muscle mass [kg], fat tissue [kg]
Eligibility Criteria
Criteria
Inclusion Criteria:
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obesity (BMI >30kg/m2),
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age >18 years,
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diagnosis of impaired glucose tolerance (IGT),
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functional autonomy,
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ability to discernment,
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no WBC treatment within the previous year.
Exclusion Criteria:
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using insulin or other chronic medications,
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inflammatory/immune-mediated pathologies,
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T2D,
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liver or kidney disease,
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cardiovascular diseases,
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neuropathy, retinopathy,
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neoplasia, as well as fragility fractures of bones,
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traumatic fractures in the previous 2 years,
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contraindications for WBC and exercise
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Ziemann Ewa | Sopot | Pomorskie | Poland | 81-735 |
Sponsors and Collaborators
- Gdansk University of Physical Education and Sport
Investigators
- Principal Investigator: Ewa Ziemann, Professor, Poznan University of Physical Education
Study Documents (Full-Text)
None provided.More Information
Publications
- Dulian K, Laskowski R, Grzywacz T, Kujach S, Flis DJ, Smaruj M, Ziemann E. The whole body cryostimulation modifies irisin concentration and reduces inflammation in middle aged, obese men. Cryobiology. 2015 Dec;71(3):398-404. doi: 10.1016/j.cryobiol.2015.10.143. Epub 2015 Oct 22.
- Lombardi G, Ziemann E, Banfi G. Whole-Body Cryotherapy in Athletes: From Therapy to Stimulation. An Updated Review of the Literature. Front Physiol. 2017 May 2;8:258. doi: 10.3389/fphys.2017.00258. eCollection 2017. Review.
- Ziemann E, Olek RA, Grzywacz T, Kaczor JJ, Antosiewicz J, Skrobot W, Kujach S, Laskowski R. Whole-body cryostimulation as an effective way of reducing exercise-induced inflammation and blood cholesterol in young men. Eur Cytokine Netw. 2014 Mar 1;25(1):14-23. doi: 10.1684/ecn.2014.0349.
- NCN 2017/25/B/NZ7/02309