CCT-PCD-1: CT in Calcified Coronary Arteries With Photon Counting Detector
Study Details
Study Description
Brief Summary
Coronary CT angiography is challenging in patients with more than mildly calcified coronary vessels, because of calcium artefacts that prevents evaluation of the lumen. The purpose of the CCT-PCD-1-study is to evaluate the diagnostic accuracy and image quality in coronary CT angiography using a commercially available CT system equipped with a photon counting detector technology.
Patients referred for cardiac CT and conventional coronary angiography as part of routine preoperative evaluation before Transcatheter Aortic Valve Implantation (TAVI) will be asked for inclusion in the study. This group of patients has generally a coronary artery calcium burden and perform cardiac CT and coronary angiography as part of routine care.
The diagnostic accuracy concerning significant coronary artery stenosis on the preoperative CT will be evaluated with the conventional coronary angiography as reference. Also, CT examination image quality will be evaluated.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Coronary CT The single cohort consists of all patients enrolled in the study. All participants performs cardiac CT and coronary angiography as part of routine care. |
Diagnostic Test: Cardiac CT with photon counting detector
Cardiac CT including the coronary arteries. The cardiac CT is performed in routine care for the included patients.
|
Outcome Measures
Primary Outcome Measures
- Diagnostic accuracy of CT concerning coronary stenosis with conventional angiography as reference [1 day. (Coronary angiography is usually performed the same day as cardiac CT.)]
Coronary angiography with or without FFR is performed as part of routine care for included patients. The outcome measure is the agreement between coronary CT and coronary angiography.
Secondary Outcome Measures
- Image quality [1 day. (Image quality is assessed on the performed examination)]
Image quality on CT examination according to European guidelines on quality criteria for computed tomography
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patients referred for cardiac CT AND conventional coronary angiography as part of routine preoperative evaluation.
Exclusion Criteria:
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<65 years old.
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Heart arrhythmia.
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Heart rate >90/min with contraindication against beta blockers.
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Not capable of giving informed consent
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eGFR <30 mL/min/1.73m2
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Region Örebro County
Investigators
- Principal Investigator: Mats Lidén, MD, PhD, Örebro University, Sweden
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 278326