Cut-Off Progesterone Values Deleterious for In Vitro Fertilization and Fresh Embryo Transfer

• Sponsor: Institut Universitari Dexeus (Other)
• Overall Status: Completed
• CT.gov ID: NCT02323347
• Collaborator: (none)
• Enrollment: 1,901
• Duration (Months): 61.9

Study Details

Study Description

Brief Summary

At which deleterious cut off value of progesterone on day of HCG (P-hCG) in our IVF program should fresh embryo transfer (ET) be cancelled?

Condition or Disease	Intervention/Treatment	Phase
Progesterone; Fertilization in Vitro; Infertility; Pregnancy	Other: Progesterone

Detailed Description

There is still an ongoing debate on the effect of subtle increased P-hCG concentration on pregnancy outcome after fresh ET. No consensus on the cut-off value to define increased P-hCG seems to exist. It is accepted that high P advances endometrium, leading to asynchrony between the implanting embryo and the endometrium, and resulting in implantation failure. A freeze all embryos policy and postponement of ET in subsequent frozen-thawed cycle has been proposed.

Study Design

• Study Type: Observational
• Actual Enrollment: 1901 participants
• Observational Model: Case-Crossover
• Time Perspective: Retrospective
• Official Title: Cut-Off Progesterone Values Deleterious for In Vitro Fertilization and Fresh Embryo Transfer
• Study Start Date: Jan 1, 2009
• Actual Primary Completion Date: Mar 1, 2014
• Actual Study Completion Date: Mar 1, 2014

Outcome Measures

Primary Outcome Measures

1. Clinical Pregnancy [6 weeks after embryo transfer procedure]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 49 Years
• Sexes Eligible for Study: Female
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Fresh embryo transfer

• Progesterone value on day HCG (Human choriogonadotrophin hormone)

Exclusion Criteria:

• Clinical indication for delaying embryo transfer

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• Institut Universitari Dexeus

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Dr. Francisca Martínez, PhD, Institut Universitari Dexeus
• ClinicalTrials.gov Identifier: NCT02323347
• Other Study ID Numbers: PROGEDEX2014
• First Posted: Dec 23, 2014
• Last Update Posted: Dec 23, 2014
• Last Verified: Dec 1, 2014

• Additional relevant MeSH terms: Infertility; Progesterone

Study Results

No Results Posted as of Dec 23, 2014