The Impact of Insulin Therapy on Protein Turnover in Pre-Diabetic Cystic Fibrosis Patients

Sponsor

University of Minnesota (Other)

Overall Status

Completed

CT.gov ID

NCT02496780

Collaborator

(none)

Enrollment

Locations

Arms

Actual Duration (Months)

Patients Per Site

0.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Insulin replacement therapy may be effective in breaking the cycle of protein catabolism, undernutrition and overall clinical deterioration in pre-diabetic, insulin insufficient CF youth because of its potent anabolic effect. A significant number of CF patients might benefit from this therapeutic approach with a substantial impact on morbidity and mortality.

Condition or Disease	Intervention/Treatment	Phase
Cystic Fibrosis	Drug: novolog insulin Drug: levemir insulin Drug: placebo	Phase 2/Phase 3

Detailed Description

Insulin insufficiency related to pancreatic fibrosis and β-cell dysfunction is present in almost every cystic fibrosis (CF) patient. Progressive abnormalities in insulin secretion begin in childhood, and, in adults, CF related diabetes (CFRD) is eventually present in more than half of the CF population. CFRD is associated with weight loss, protein catabolism, loss of lean body mass (LBM), and early death from lung disease and malnutrition. The negative consequences of diabetes are just the "tip of the iceberg", since clinical deterioration has been documented to begin in the pre-diabetic period. Non-diabetic glucose tolerance abnormalities in CF are associated with protein catabolism, weight loss and lung function decline, all of which correlate with the severity of insulin secretory defects, suggesting a key pathologic role for insulin insufficiency. Insulin is a potent anabolic hormone, critical for maintenance of body weight and muscle mass. In a placebo-controlled clinical trial, insulin therapy improved body mass index (BMI) and LBM in patients with very early CFRD (CFRD without fasting hyperglycemia), and this is now standard care for these patients. There is growing preliminary evidence that insulin therapy is beneficial even earlier, in CF patients with pre-diabetes due to insulin insufficiency. Given the universal prevalence of insulin insufficiency in CF, the high lifetime risk of developing diabetes, the clinical impact of insulin insufficiency on protein catabolism and survival in CF, and the critical importance of maintaining body weight and LBM in this population, there is an urgent need to determine whether insulin replacement therapy should be instituted for anabolic purposes prior to the actual onset of diabetes and, if so, to ascertain the optimal regimen. The current protocol describes a double-blind, placebo-controlled trial to determine whether insulin therapy improves protein catabolism in youth with CF and abnormal glucose tolerance, and to explore differences in efficacy between multiple daily pre-meal insulin dosing (as is currently standard for early CFRD) versus a more convenient once daily basal insulin dose (as has been used in small uncontrolled pilot studies). The findings of this study will provide a mechanistic rationale for instituting insulin in youth with CF and pre-diabetes, and will inform both research studies and clinical practice as to the best regimen for insulin delivery in this population.

Study Design

Study Type:

Interventional

Actual Enrollment :

66 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Triple (Participant, Care Provider, Investigator)

Primary Purpose:

Treatment

Official Title:

The Impact of Insulin Therapy on Protein Turnover in Pre-Diabetic Cystic Fibrosis Patients

Actual Study Start Date :

Aug 1, 2015

Actual Primary Completion Date :

Jul 1, 2022

Actual Study Completion Date :

Jul 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
Placebo Comparator: placebo once or 3x daily injectable placebo (insulin diluent)	Drug: placebo once or 3x daily Other Names: insulin diluent
Experimental: basal insulin levemir once daily basal insulin therapy with insulin levemir	Drug: levemir insulin basal insulin once a day Other Names: detemir
Experimental: rapid-acting insulin Novolog pre-meal rapid-acting insulin 3x/day with insulin novolog	Drug: novolog insulin 3x daily rapid-acting insulin Other Names: apart

Arm

Intervention/Treatment

Placebo Comparator: placebo

once or 3x daily injectable placebo (insulin diluent)

Drug: placebo

once or 3x daily

Other Names:

insulin diluent

Experimental: basal insulin levemir

once daily basal insulin therapy with insulin levemir

Drug: levemir insulin

basal insulin once a day

Other Names:

detemir

Experimental: rapid-acting insulin Novolog

pre-meal rapid-acting insulin 3x/day with insulin novolog

Drug: novolog insulin

3x daily rapid-acting insulin

Other Names:

apart

Outcome Measures

Primary Outcome Measures

post-prandial protein turnover [5 hour meal study]
triple tracer of phenylalanine meal study, results reported as rate of appearance and disappearance of phenylalanine during a 5 hour meal study at baseline and after 1 month of insulin or placebo therapy

Eligibility Criteria

Criteria

Ages Eligible for Study:

10 Years to 25 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Diagnosis of cystic fibrosis, age 10-25 years
A standard routine annual OGTT performed within 12 months of randomization
Abnormal glucose tolerance, with a fasting glucose level <126 mg/dl and

The 1-hr OGTT glucose is ≥200 mg/dl but the 2-hr glucose is <140 (INDET), OR
The 2-hour OGTT glucose is 140-199 mg/dl (impaired glucose tolerance, IGT).

Exclusion Criteria:

Diagnosis of CFRD, Consensus Conference definition (45)
Previous organ transplant, or transplant imminent during study period
BMI percentile >95
Treatment with systemic glucocorticoids (nasal or inhaled glucocorticoids are acceptable)
Therapy with growth hormone or Megace
Nighttime continuous drip gastrostomy/jejunostomy feedings
Pregnancy or breast-feeding or plans to become pregnant during study period
Any change in medications during the 3 months prior to the study

• Exception: the new corrector/potentiator combination drug lumacaftor/ivacaftor is expected to get FDA approval in early 2015, and most CF patients with severe genotypes, including many eligible for this proposal, will receive this drug. This is not a contraindication to participation in the current proposal (and participation in other studies is not contraindicated in the PROSPECT post-marketing drug study). Though the primary effects of the combination therapy appear to be apparent after 1 month, we will wait 6 months after initiation of lumacaftor/ivacaftor before enrollment in this study to make sure subjects are in a steady state.