Database of All Patients Who Have Undergone Pulmonary Function Testing at Singapore General Hospital

• Sponsor: Singapore General Hospital (Other)
• Overall Status: Completed
• CT.gov ID: NCT01601288
• Collaborator: (none)
• Enrollment: 17,000
• Location: 1
• Duration (Months): 67
• Patients Per Site Per Month: 253.6

Study Details

Study Description

Brief Summary

The purpose of this study is to create a prospective database of all patients who have undergone pulmonary function testing from which the investigators can study the clinical phenotypes of various respiratory conditions. The investigators hope by understanding the differences in these myriad phenotypes to be able to provide individualized, patient-targeted therapy in the future.

Condition or Disease	Intervention/Treatment	Phase
Obstructive Pulmonary Diseases; Restrictive Lung Disease; Cough; Dyspnea

Detailed Description

Recent studies have shown that clinical phenotyping of patients with various respiratory conditions is important in the understanding of the disease process, clinical response to treatment, and prognosis. Pulmonary function testing is a very important aspect of clinical phenotyping in many respiratory conditions. Creating a database will enable us to study the various phenotypes within each respiratory condition. This will allow us to better understand each disease, with a view to provide personalized patient care targeted at their specific phenotype and hence better clinical outcomes.

Study Design

• Study Type: Observational
• Actual Enrollment: 17000 participants
• Observational Model: Case-Only
• Time Perspective: Prospective
• Official Title: Prospective Database of All Patients Who Have Undergone Pulmonary Function Testing at Singapore General Hospital
• Study Start Date: May 1, 2012
• Actual Primary Completion Date: Dec 1, 2017
• Actual Study Completion Date: Dec 1, 2017

Outcome Measures

Primary Outcome Measures

1. Diagnoses based on pulmonary function test interpretation [7 days]

   Interpretation of pulmonary function tests by a certified respiratory physician

Eligibility Criteria

Criteria

• Ages Eligible for Study: 12 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

1. All patients who have undergone pulmonary function testing at the Singapore General Hospital pulmonary function laboratory

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Singapore General Hospital	Singapore		Singapore	169608

Sponsors and Collaborators

• Singapore General Hospital

Investigators

• Principal Investigator: Su Ying Low, BMBCh, Singapore General Hospital

Study Documents (Full-Text)

None provided.

More Information

Publications

• Nathan SD, Shlobin OA, Weir N, Ahmad S, Kaldjob JM, Battle E, Sheridan MJ, du Bois RM. Long-term course and prognosis of idiopathic pulmonary fibrosis in the new millennium. Chest. 2011 Jul;140(1):221-229. doi: 10.1378/chest.10-2572. Review.
• Nishimura M, Makita H, Nagai K, Konno S, Nasuhara Y, Hasegawa M, Shimizu K, Betsuyaku T, Ito YM, Fuke S, Igarashi T, Akiyama Y, Ogura S; Hokkaido COPD Cohort Study Investigators. Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012 Jan 1;185(1):44-52. doi: 10.1164/rccm.201106-0992OC.

• Responsible Party: Singapore General Hospital
• ClinicalTrials.gov Identifier: NCT01601288
• Other Study ID Numbers: 2011/845/Cpftdatabase
• First Posted: May 17, 2012
• Last Update Posted: May 15, 2019
• Last Verified: May 1, 2019

• Keywords provided by Singapore General Hospital: obstructive lung disease; restrictive lung disease; cough; dyspnea
• Additional relevant MeSH terms: Lung Diseases; Lung Diseases, Obstructive; Dyspnea

Study Results

No Results Posted as of May 15, 2019