pet-ct: Defining PET / CT Protocols With Optimized F18-FDG (Fluorodeoxyglucose) Dose, Focusing on Reduced Radiation Dose and Improved Image Quality
Study Details
Study Description
Brief Summary
Identify the best combination of predictive variables that influence ionizing radiation dose and improved image quality through analysis and quantification of PET-CT images in simulators and patients.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Retrospective development cohort A total of 85 18F-FDG-PET adult studies were gathered over a 3-month period and retrospectively evaluated. |
Other: Image quantify
Will be observed all patients who perform PET / CT examinations, independent of clinical indication, in nuclear medicine at Hospital Sao Rafael. Those who show interest in participating in the study, will be provided free and informed consent form (ICF) for your appreciation. This evaluation will serve for analysis and quantification of PET-CT images.
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| Prospective validation cohort To verify the application of methodology in clinical routine, we conducted a second phase of the study prospectively in 250 subjects (phase 2) using inclusion and exclusion criteria of the retrospective study (phase 1). |
Other: Image quantify
Will be observed all patients who perform PET / CT examinations, independent of clinical indication, in nuclear medicine at Hospital Sao Rafael. Those who show interest in participating in the study, will be provided free and informed consent form (ICF) for your appreciation. This evaluation will serve for analysis and quantification of PET-CT images.
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Outcome Measures
Primary Outcome Measures
- Correlation of body weight with the variation coefficient (image noise). [360 seconds]
The image noise will be measured by VOI (Volume Of Interest) in the images. The units of measure will be kilograms (kg) for body weight, and percentage for the variation coefficient.
Secondary Outcome Measures
- Correlation of dose-regimen with the variation coefficient (image noise). [360 seconds]
The dose-regimen will be calculated based on radiation dose and body surface. The image noise will be measured by VOI (Volume Of Interest) in the images. The units of measure will be MegaBecquerel per kilogram (MBq/kg) for dose-regimen, and percentage for the variation coefficient.
- Correlation of acquisition protocol time with the variation coefficient (image noise). [360 seconds]
Images will be acquired every 30 seconds until a maximum of 360 seconds. The image noise will be measured by VOI (Volume Of Interest) in the images. The units of measure will be seconds for the acquisition time, and percentage for the variation coefficient.
Eligibility Criteria
Criteria
Inclusion Criteria:
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Healthy volunteers;
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Both genders;
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Age over 18 years;
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Clinical indication for PET-CT scan.
Exclusion Criteria:
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Pregnant women;
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Patients who have lesions in the liver metabolically active whether primary or metastatic;
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Patients with movement difficulties.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hospital Sao Rafael | Salvador | Bahia | Brazil |
Sponsors and Collaborators
- Hospital Sao Rafael
Investigators
- Principal Investigator: Milena BP Soares, PhD, Hospital São Rafael
- Study Chair: Vinicius O Menezes, BSc, Hospital São Rafael
- Study Chair: Marcos AD Machado, BSc, Hospital São Rafael
- Study Chair: Cleiton C Queiroz, BSc, Hospital São Rafael
- Study Chair: Mauro Namias, MSc, Fundacion Centro Diagnostico Nuclear
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 27558714.4.0000.0048