Definition for Biliary Atresia Associated Cholangitis After Surgery
Study Details
Study Description
Brief Summary
Cholangitis is the most common postoperative complication of biliary atresia, with a reported incidence of 40-90%, which seriously affects the surgical effect, survival rate and the quality of life and prognosis of patients. Without of direct evidence, the diagnosis of cholangitis sometimes is difficult to make, thus most of them are diagnosed based on the symptoms of children. According to literature reports, different centers and regions have different diagnostic criteria for postoperative cholangitis after hepatic portoenterostomy, which has a great influence on the accuracy of the incidence rate and appropriate treatment of cholangitis, and also brings differences in the analysis of the causes and prognostic factors of cholangitis.
Based on the above reasons, we used the Delphi method，in which worldwidely 48 experts participated in, to establish the diagnostic scoring system for postoperative cholangitis after biliary atresia.
Now we aimed to verify the specificity and sensitivity of the new scoring system through clinical cases, in order to unify and standardize the diagnostic criteria and provide help for the diagnosis and treatment of cholangitis after biliary atresia.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Postoperative cholangitis Patients who had conducted kasai procedure and suffered from postoperative cholangitis after surgery |
Drug: Intravenous Antibodies
Treatment is usually performed with sensitive third-generation cephalosporins, and medication is adjusted according to blood culture results
|
| None postoperative cholangitis Patients who had conducted kasai procedure and followed up in a clinic，at which time they didn't present signs of cholangitis |
Outcome Measures
Primary Outcome Measures
- Diagnostic cholangitis score [Two years]
The values of the two groups' scores were calculated separately
Secondary Outcome Measures
- Score estimates for treatment of cholangitis [Two years]
In the cholangitis group, the correlation between evaluation score and treatment was studied
Eligibility Criteria
Criteria
Inclusion Criteria:
① Admission time: 2019.01.01-2021.12.31;
② The first diagnosis after discharge was cholangitis
Exclusion Criteria:
① Cholangitis after non-Kasai procedure;
- Postoperative cholangitis of biliary atresia not operated in the unit; ③ Patient has been treated in other hospitals during this episode; ④ The treatment period for cholangitis is not completed or the patient is discharged automatically.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | NJMU | Nanjing | Jiangsu | China |
Sponsors and Collaborators
- Nanjing Children's Hospital
Investigators
- Study Chair: Tang weibing, Dr, Nanjing Children's Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- ERBAAC