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Effects of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

Sponsor
Mayo Clinic (Other)
Overall Status
Completed
CT.gov ID
NCT01738568
Collaborator
(none)
27
Enrollment
1
Location
1
Arm
28.4
Duration (Months)
1
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Aging is associated with a loss of brain function and conditions such as dementia and Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the progression of age related degenerative diseases. Aerobic exercise training can increase brain volumes and is associated with decreased risk for degenerative brain conditions. However, little is know about the changes that occur to brain metabolism with aerobic training and aging.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: High intensity aerobic training
  • Behavioral: Sedentary Control
 N/A

Study Design

Study Type:
Interventional
Actual Enrollment :
27 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Basic Science
Official Title:
Effect of Aging and Aerobic Exercise Training on Brain Glucose Metabolism
Study Start Date :
Oct 1, 2012
Actual Primary Completion Date :
Feb 12, 2015
Actual Study Completion Date :
Feb 12, 2015

Arms and Interventions

Arm Intervention/Treatment
Experimental: Exercise

Aerobic exercise

Behavioral: High intensity aerobic training
High intensity aerobic interval training will be performed 12-weeks. Exercise training will last 1 hour per day, 5 days per week and include high intensity interval cycling at ~70-95% maximum workload for 4 minutes followed by 3 minutes of rest.

Behavioral: Sedentary Control
Sedentary control participants will not perform any regular exercise for 12-weeks.

Outcome Measures

Primary Outcome Measures

  1. Change in Brain Glucose Uptake [12 weeks]

    The investigators will assess brain glucose uptake using positron emission tomography at baseline and following 12-weeks of either aerobic exercise training or sedentary control period.

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes

Healthy sedentary adults aged 18-30 or 65-80 years of all ethnicities will be eligible. Pregnant women, children, prisoners or other at risk populations will not be recruited.

Inclusion Criteria:
  • Age 18-30 years or 65-80 years
Exclusion Criteria:

  • Body mass index (BMI) >31 kg/m2

  • Smoking

  • Pregnancy

  • Participation in structured exercise (>2 times per week for 30 minutes or longer)

  • Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease

  • Orthopedic problems that would keep them from being able to ride an exercise bicycle, lift weights or do a combination of these exercise

  • Medications that are known to impact on mitochondrial function: Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist)

  • Claustrophobia

Contacts and Locations

Locations

Site City State Country Postal Code
1 Mayo Clinic in Rochester Rochester Minnesota United States 55905

Sponsors and Collaborators

  • Mayo Clinic

Investigators

  • Principal Investigator: Val Lowe, MD, Mayo Clinic

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

Publications

None provided.
Responsible Party:
Val Lowe, PI, Mayo Clinic
ClinicalTrials.gov Identifier:
NCT01738568
Other Study ID Numbers:
  • 12-003357
First Posted:
Nov 30, 2012
Last Update Posted:
Aug 30, 2021
Last Verified:
Aug 1, 2021
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Val Lowe, PI, Mayo Clinic
High intensity aerobic training
Additional relevant MeSH terms:
Dementia

Study Results

No Results Posted as of Aug 30, 2021