Dental Erosion in Patients With Gastro-oesophageal Reflux
Study Details
Study Description
Brief Summary
Not only caries but also exposure to acids can lead to loss of tooth structure. This acid-related tooth structure loss is defined as dental erosion.
A relationship between dental erosion and occurence of reflux disease was shown in numerous studies. On the one hand, patients with dental erosions frequently show reflux disease. On the other hand, many - but not all - reflux patients show dental erosions. It is believed that certain salivary parameters might explain, why not all reflux patients alike are affected of dental erosions.
The aim of this study is to analyze the relationship and the extent of occurrence of dental erosions and reflux symptoms, including investigation of certain salivary parameters.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Reflux patients Patients who are treated at the Clinic for Gastroenterology and Gastrointestinal Oncology and have a 24-hours pH monitoring or impedance measurement performed for medical reasons |
Other: Collection of saliva samples
Collection of saliva samples
Other: Visual detection of BEWE-index
Visual detection of BEWE-index
|
Outcome Measures
Primary Outcome Measures
- Visual assessment of the BEWE-(basic erosive wear examination)-index [After removal of the probe (on second day)]
Secondary Outcome Measures
- Determination of unstimulated and stimulated saliva flow rate (ml/min). [While wearing the probe at three time points over 24h: morning, noon, evening]
- Determination of saliva pH and buffer capacity (mol/L). [While wearing the probe at three time points over 24h: morning, noon, evening]
- Determination of total protein content in saliva (g/L). [While wearing the probe at three time points over 24h: morning, noon, evening]
- Determination inorganic calcium and phosphate in saliva (mmol/L). [While wearing the probe at three time points over 24h: morning, noon, evening]
- Measurement of salivary enzyme activity: Protease, Kollagenase/Gelatinase, Pepsin, Trypsin, and Amylase (U/mL). [While wearing the probe at three time points over 24h: morning, noon, evening]
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patients who are treated at the Clinic for Gastroenterology and Gastrointestinal Oncology and have a 24-hours pH monitoring or impedance measurement performed for medical reasons
Exclusion Criteria:
-
Inability to give written consent
-
Age <18 years
-
Intake of proton pump inhibitors (PPIs) if they are not discontinued at least one week before study participation
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- University of Göttingen
Investigators
- Principal Investigator: Annette Wiegand, Prof. Dr. med. dent., Dept. of Prev. Dentistry, Periodontology and Cariology, University Medical Center Göttingen, Germany
Study Documents (Full-Text)
None provided.More Information
Publications
- Bartlett D, Ganss C, Lussi A. Basic Erosive Wear Examination (BEWE): a new scoring system for scientific and clinical needs. Clin Oral Investig. 2008 Mar;12 Suppl 1:S65-8. doi: 10.1007/s00784-007-0181-5. Epub 2008 Jan 29.
- Hara AT, Zero DT. The potential of saliva in protecting against dental erosion. Monogr Oral Sci. 2014;25:197-205. doi: 10.1159/000360372. Epub 2014 Jun 26. Review.
- Kanzow P, Wegehaupt FJ, Attin T, Wiegand A. Etiology and pathogenesis of dental erosion. Quintessence Int. 2016 Apr;47(4):275-8. doi: 10.3290/j.qi.a35625. Review.
- Moazzez R, Bartlett D, Anggiansah A. Dental erosion, gastro-oesophageal reflux disease and saliva: how are they related? J Dent. 2004 Aug;32(6):489-94.
- Ranjitkar S, Smales RJ, Kaidonis JA. Oral manifestations of gastroesophageal reflux disease. J Gastroenterol Hepatol. 2012 Jan;27(1):21-7. doi: 10.1111/j.1440-1746.2011.06945.x. Review.
- Schlueter N, Ganss C, Pötschke S, Klimek J, Hannig C. Enzyme activities in the oral fluids of patients suffering from bulimia: a controlled clinical trial. Caries Res. 2012;46(2):130-9. doi: 10.1159/000337105. Epub 2012 Apr 3.
- Wang GR, Zhang H, Wang ZG, Jiang GS, Guo CH. Relationship between dental erosion and respiratory symptoms in patients with gastro-oesophageal reflux disease. J Dent. 2010 Nov;38(11):892-8. doi: 10.1016/j.jdent.2010.08.001. Epub 2010 Aug 7.
- Wilder-Smith CH, Materna A, Martig L, Lussi A. Gastro-oesophageal reflux is common in oligosymptomatic patients with dental erosion: A pH-impedance and endoscopic study. United European Gastroenterol J. 2015 Apr;3(2):174-81. doi: 10.1177/2050640614550852.
- Erosion-Reflux
- 2/11/15