Mindfulness Based Cognitive Therapy for Recurrent Depression
Study Details
Study Description
Brief Summary
The purpose of this study is to investigate the effectiveness and possible mediating factors of Mindfulness Based Cognitive Therapy (MBCT) for recurrent depression.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Mindfulness Based Cognitive Therapy (MBCT) is a 8 session group intervention and is well described by several authors.
Previous studies showed Mindfulness Based Cognitive Therapy (MBCT) to be effective to prevent relapse in patients with recurrent depression and 3 or more previous depressive episodes.
Study aims are:
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to replicate previous findings in The Netherlands, by a research team which did not develop the intervention
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to investigate if MBCT is applicable for patients with recurrent depression and current depressive symptoms
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to examine possible mediators of treatment effect and predictors of relapse in the year following the treatment
In this study, patients are randomly assigned to a MBCT intervention group or a waiting list control group. Patients allocated to the waiting list control condition will receive the MBCT course three months later. All patients who participated in a MBCT training will be assessed during the year following the completion of the MBCT course. We aim to include about 220 patients.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Mindfulness Based Cognitive Therapy Mindfulness Based Cognitive Therapy |
Behavioral: Mindfulness Based Cognitive Therapy
8-weeks group based intervention of mindfulness and cognitive behavioural techniques
Other Names:
|
| No Intervention: Waiting list control group 3-month waiting list group |
Outcome Measures
Primary Outcome Measures
- Relapse/Recurrence of Major Depressive Episode [6, 9, 12, 15 months]
Secondary Outcome Measures
- Psychiatric symptoms and mindfulness skills measured by questionnaires [0, 3, 6, 9, 12, 15 months]
Eligibility Criteria
Criteria
Inclusion Criteria:
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3 or more previous depressive episodes
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if treated with medication: constant dose of at least 6 weeks
Exclusion Criteria:
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Bipolar Disorder
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Psychotic disorder
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Neurological or somatic illness affecting depression or outcome measures
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Current alcohol or drugs dependency
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Acute need of psychiatric treatment
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Radboud University Nijmegen Medical Center | Nijmegen | Gelderland | Netherlands | 6525 GC |
Sponsors and Collaborators
- Radboud University Medical Center
- Fonds Psychische Gezondheid
Investigators
- Principal Investigator: Anne EM Speckens, Prof. dr., Radboud University Medical Center
Study Documents (Full-Text)
None provided.More Information
Publications
- Barnhofer T, Crane C, Hargus E, Amarasinghe M, Winder R, Williams JM. Mindfulness-based cognitive therapy as a treatment for chronic depression: A preliminary study. Behav Res Ther. 2009 May;47(5):366-73. doi: 10.1016/j.brat.2009.01.019. Epub 2009 Feb 5.
- Kenny MA, Williams JM. Treatment-resistant depressed patients show a good response to Mindfulness-based Cognitive Therapy. Behav Res Ther. 2007 Mar;45(3):617-25. Epub 2006 Jun 23.
- Kingston T, Dooley B, Bates A, Lawlor E, Malone K. Mindfulness-based cognitive therapy for residual depressive symptoms. Psychol Psychother. 2007 Jun;80(Pt 2):193-203.
- Ma SH, Teasdale JD. Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects. J Consult Clin Psychol. 2004 Feb;72(1):31-40.
- Teasdale JD, Segal ZV, Williams JM, Ridgeway VA, Soulsby JM, Lau MA. Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. J Consult Clin Psychol. 2000 Aug;68(4):615-23.
- MFN-2005-2010
- 2005 6028