MIDE: Exercise Capacity of Patients With Dermatomyosis
Study Details
Study Description
Brief Summary
Dermatomyositis (DM) patients experience muscle weakness and low aerobic capacities, which are associated with poor health status and increased mortality. The origin of this muscle impairment remains unknown.
The investigators hypothesize that mitochondria functioning is impaired in DM muscle and links with exercise capacities.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Dermatomyositis (DM) Patients with dermatomyositis according to ENMC criteria |
Other: exploration
Difference of the following parameters in patients i) with DM, ii) with another inflammatory myopathy iii) without neuromuscular disease.
|
| Active Comparator: Non-dermatomyositis inflammatory myopathies Patients with other inflammatory myopathy than dermatomyositis according to ENMC criteria |
Other: exploration
Difference of the following parameters in patients i) with DM, ii) with another inflammatory myopathy iii) without neuromuscular disease.
|
| No Intervention: No myopathy Patients without myopathy on muscle biopsy |
Outcome Measures
Primary Outcome Measures
- Difference in the capacity of muscle fibers to consume oxygen in the muscle of patients i) with DM, ii) with other inflammatory myopathy, iii) without neuromuscular disease. [Baseline]
This difference in mitochondrial breathing capacity in the muscle will be achieved by: Muscle biopsy
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Woman or man> 18 years,
-
Signature of informed consent,
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Muscle biopsy for suspicion of recent inflammatory myopathy (<6 months) or for exclusion of neuromuscular pathology.
Prospectively, following the results of the muscle biopsy, the subjects will divided into three groups meeting the following criteria:
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"DM" group: DM according to the ENMC criteria;
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"other inflammatory myopathy" group: polymyositis, autoimmune necrotizing myopathy, non-specific myositis or inclusion myositis according to the ENMC criteria;
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Group "no neuromuscular pathology": i) myalgia and / or intolerance to exercise and
- normal neuromuscular examination, iii) no increase in blood creatine kinase level,
- absence of electromyographic abnormality, v) histological Muscle mass.
Exclusion Criteria:
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- Taking an immunomodulatory treatment within 6 months before inclusion,
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Paraneoplastic form of the disease,
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Presence of associated interstitial pneumonitis,
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Neuromuscular pathology different from inflammatory myopathy,
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Unbalanced cardiovascular disease,
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Impossibility of giving the subject informed information (subject in an emergency situation, difficulty in understanding the subject, ...),
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Subject under safeguard of justice,
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Subject under tutelage or under curators,
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Pregnancy (positive pregnancy test)
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Breastfeeding.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Meyer | Strasbourg | France | 67000 |
Sponsors and Collaborators
- University Hospital, Strasbourg, France
Investigators
- Principal Investigator: Alain Meyer, Les Hôpitaux Universitaires de Strasbourg
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 6431