Description of Eosinophilic Pneumonia in BJI/PJI Treated by Daptomycin
Study Details
Study Description
Brief Summary
Daptomycin is an antibiotic from the family of cyclic lipopeptides, bactericide, concentration-dependent. Its spectrum concerns Gram-positive bacteria.
Since the authorization of daptomycin in 2006, cases of eosinophilic pneumonia and pulmonary eosinophilia associated with its use have been reported in Europe and worldwide.
The purpose of this study is to describe the mechanism of occurrence of this AE with dapto; Prolonged exposure and accumulation at the alveolar level could potentially have a role. Better understanding the mechanisms of appearance of this AE would provide predictive elements making it possible to limit the occurrence of this AE in the future
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Daptomycin is an antibiotic from the family of cyclic lipopeptides, bactericide, concentration-dependent. Its spectrum concerns Gram-positive bacteria.
The Infectious Diseases Society of America recommends the use of daptomycin 6 mg / kg / day in the second-line treatment of IOA on staphylococcal but also enterococcal prostheses, as an alternative to vancomycin and linezolid.
In case of renal failure, daptomycin is often considered as a good therapeutic alternative to glycopeptides.
Since the authorization of daptomycin in 2006, cases of eosinophilic pneumonia and pulmonary eosinophilia associated with its use have been reported in Europe and worldwide. Although a large proportion of cases have been reported in patients receiving daptomycin in unapproved indications, the use of daptomycin in authorized indications has also been associated with this risk.
The dosage of daptomycin makes it possible to evaluate its effectiveness and prevent the occurrence of a overdose, provider of side effects.
The purpose of this study is to describe the mechanism of occurrence of this AE with dapto; Prolonged exposure and accumulation at the alveolar level could potentially have a role. Better understanding the mechanisms of appearance of this AE would provide predictive elements making it possible to limit the occurrence of this AE in the future
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Eosinophilic pneumonia on daptomycin patients having an osteoarticular infection treated with daptomycin and which developped eosinophilic pneumonia |
Other: Description of eosinophilic pneumonia due to daptomycine
Description of eosinophilic pneumonia in patients treated by daptomycin for an osteoarticular infection
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Outcome Measures
Primary Outcome Measures
- description of BJI/BJI in patients having eosinophilic pneumonia due to daptomycin [2 months]
description of the BJI/PJI (symptoms, type of evolution, type of implant)
- description patients having eosinophilic pneumonia due to daptomycin [2 months]
description of the patients (average age, medical background)
- rate of eosinophilic pneumonia due to daptomycin in osteoarticular infection: the adverse event [6 months]
number of cases and description of the adverse event as assessed by CTCAE v4.0
- Evalutation of eosinophilic pneumonia due to daptomycin in osteoarticular infection: dosage of daptomycine [6 months]
description of the use of daptomycine : dosage
- Evalutation of eosinophilic pneumonia due to daptomycin in osteoarticular infection: duration of daptomycine [6 months]
description of the use of daptomycine : duration
- Evalutation of eosinophilic pneumonia due to daptomycin in osteoarticular infection: daptomycine plasma clearance [6 months]
mean daptomycine plasma clearance (unit, liters per hour)
- Evalutation of eosinophilic pneumonia due to daptomycin in osteoarticular infection: daptomycine volume distribution [6 months]
mean daptomycine volume of distribution (unit, liters)
Eligibility Criteria
Criteria
Inclusion Criteria:
- patients having had an eosinophilic pneumonia under daptomycine given to treat an osteoarticular infection (BJI/PJI)
Exclusion Criteria:
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Hospices Civils de Lyon | Lyon | France | 69004 |
Sponsors and Collaborators
- Hospices Civils de Lyon
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- 19-283