TREMORHYTHM: Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity

Sponsor

Henri Mondor University Hospital (Other)

Overall Status

Recruiting

CT.gov ID

NCT05998486

Collaborator

(none)

Enrollment

Location

8.9

Anticipated Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify and track during disease progression. This study propose to explore the rhythmicity of distal muscle contractions in the upper limb to characterize resting tremor and discriminate it from cerebellar tremor (CT) based on the frequency spectrum of the EMG signal.

Condition or Disease	Intervention/Treatment	Phase
Parkinson Cerebellar Tumor Rest Tremor Diagnoses Disease Movement; Abnormal, Involuntary	Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators

Detailed Description

This retrospective study analyzed surface EMG recordings of wrist flexor-pronators and extensor-supinators from patients with PD or CT bilaterally in five 10-second conditions: rest with contralateral motor distraction, symmetrical arms extended forward posture with hands pronated, semi-pronation, supination, and elbows flexed with hands pronated. The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.

Study Design

Study Type:

Observational

Anticipated Enrollment :

80 participants

Observational Model:

Cohort

Time Perspective:

Retrospective

Official Title:

Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity

Actual Study Start Date :

Apr 3, 2023

Anticipated Primary Completion Date :

Sep 30, 2023

Anticipated Study Completion Date :

Dec 31, 2023

Arms and Interventions

Arm	Intervention/Treatment
Tremor of rest Patient with a diagnosis of Parkinson's disease and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories	Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators The subject is asked to perform a series of tasks: resting posture, symmetrical posture arms forward, unilateral distal movement. Each task lasts 10 seconds.
Cerebellar tremor Patient with a diagnosis of cerebellar tremor and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories	Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators The subject is asked to perform a series of tasks: resting posture, symmetrical posture arms forward, unilateral distal movement. Each task lasts 10 seconds.

Arm

Intervention/Treatment

Tremor of rest

Patient with a diagnosis of Parkinson's disease and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories

Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators

The subject is asked to perform a series of tasks: resting posture, symmetrical posture arms forward, unilateral distal movement. Each task lasts 10 seconds.

Cerebellar tremor

Patient with a diagnosis of cerebellar tremor and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories

Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators

The subject is asked to perform a series of tasks: resting posture, symmetrical posture arms forward, unilateral distal movement. Each task lasts 10 seconds.

Outcome Measures

Primary Outcome Measures

rhythmicity index [10 seconds]
The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 100 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

patient who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators in Laboratories;
diagnosis of Parkinson's disease or cerebellar tremor.

Exclusion Criteria:

Botulinium toxin injection in upper limb during a delay of 3 months before surface EMG recordings;
Levodopa drugs administrated during a delay of 12 hours before surface EMG recordings;
Tremor-favour drugs administrated during a delay of 30 days before surface EMG recordings;
Presence of an other neurologic disease or of any disease associated with motor disorders in upper limb.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Laboratoire Analyse et Restauration du Mouvement	Créteil		France

Sponsors and Collaborators

Henri Mondor University Hospital

Investigators

Principal Investigator: Emilie Hutin, Henri Mondor University Hospital

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Emilie Hutin, Co-director of laboratory, Henri Mondor University Hospital

ClinicalTrials.gov Identifier:

NCT05998486

Other Study ID Numbers:

ARM-Tremor

First Posted:

Aug 21, 2023

Last Update Posted:

Aug 21, 2023

Last Verified:

Aug 1, 2023

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

Cerebellar Neoplasms

Parkinson Disease

Tremor

Study Results

No Results Posted as of Aug 21, 2023