Detection of Electrocardiographic Brugada Patterns Using High Precordial Leads
Study Details
Study Description
Brief Summary
Detection of prevalence of Brugada patterns in our locality in asymptomatic patients , by standard 12 lead ECG level and high precordial ECG level, measuring how much the high precordial leads is more sensitive in Brugada patterns detection than standard level 12 lead ECG in our upper Egyptian population.
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Detailed Description
Detection of prevalence of Brugada patterns in our locality in asymptomatic patients , by standard 12 lead ECG level and high precordial ECG level, measuring how much the high precordial leads is more sensitive in Brugada patterns detection than standard level 12 lead ECG in our upper Egyptian population.
The study will include patients fulfilling our criteria presenting to cardiology outpatient clinic and emergency room of Assiut University hospitals.
Study Design
Outcome Measures
Primary Outcome Measures
- Detection of electrocardiographic Brugada patterns using high precordial leads positioning among asymptomatic upper Egyptian population [up to 4 hours for each case to make sure of meeting eligibility criteria]
Detection of prevalence of Brugada patterns in our locality in asymptomatic patients , by standard 12 lead ECG level and high precordial ECG level, measuring how much the high precordial leads is more sensitive in Brugada patterns detection than standard level 12 lead ECG in our upper Egyptian population.
Secondary Outcome Measures
- Follow up of positive cases [six months after diagnosis of Brugada pattern for each case]
The positive cases will be educated regarding their condition, asked about their history of syncope and family history of sudden cardiac death and will be educated about avoiding and rapid management of fever and electrolyte disturbances and educated about the list of drugs to be avoided. The positive cases will be followed up for 6 months both clinically and by Holter at 1st, and 6th month for detection of subclinical ventricular arrhythmias.
Eligibility Criteria
Criteria
Inclusion Criteria:
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patients with IHD,HTN,DM with no organic heart disease by ECHO.
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healthy persons with normal structure heart by ECHO.
Exclusion Criteria:
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Acute coronary syndrome.
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cardiomyopathy.
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severe valvular heart disease.
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HTN heart disease with LVH.
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Malignancy.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Assiut University
Investigators
- Study Director: Salah Eldin Sayed Atta, Professor, Assiut University
- Study Director: Mahmoud Abdelsabour, Lecturer, Assiut University
Study Documents (Full-Text)
None provided.More Information
Publications
- Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, Gussak I, LeMarec H, Nademanee K, Perez Riera AR, Shimizu W, Schulze-Bahr E, Tan H, Wilde A. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation. 2005 Feb 8;111(5):659-70. Epub 2005 Jan 17. Review. Erratum in: Circulation. 2005 Jul 26;112(4):e74.
- Bachman JW, Field CS, Hammersley CE. Educational program for premature labor. J Am Board Fam Pract. 1992 Nov-Dec;5(6):645-7.
- Chung EH. Brugada ECG patterns in athletes. J Electrocardiol. 2015 Jul-Aug;48(4):539-43. doi: 10.1016/j.jelectrocard.2015.05.001. Epub 2015 May 8. Review.
- Kapplinger JD, Tester DJ, Alders M, Benito B, Berthet M, Brugada J, Brugada P, Fressart V, Guerchicoff A, Harris-Kerr C, Kamakura S, Kyndt F, Koopmann TT, Miyamoto Y, Pfeiffer R, Pollevick GD, Probst V, Zumhagen S, Vatta M, Towbin JA, Shimizu W, Schulze-Bahr E, Antzelevitch C, Salisbury BA, Guicheney P, Wilde AA, Brugada R, Schott JJ, Ackerman MJ. An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. Heart Rhythm. 2010 Jan;7(1):33-46. doi: 10.1016/j.hrthm.2009.09.069. Epub 2009 Oct 8.
- Meregalli PG, Wilde AA, Tan HL. Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more? Cardiovasc Res. 2005 Aug 15;67(3):367-78. Review.
- Patel SS, Anees S, Ferrick KJ. Prevalence of a Brugada pattern electrocardiogram in an urban population in the United States. Pacing Clin Electrophysiol. 2009 Jun;32(6):704-8. doi: 10.1111/j.1540-8159.2009.02354.x. Erratum in: Pacing Clin Electrophysiol. 2009 Jul;32(7):968. Anees, Syed S [corrected to Anees, Syed].
- Peritz DC, Chung EH. Criteria for evaluating rSr' patterns due to high precordial ECG lead placement accurately confirm absence of a Brugada ECG pattern. J Electrocardiol. 2016 Mar-Apr;49(2):182-6. doi: 10.1016/j.jelectrocard.2015.12.015. Epub 2016 Jan 6.
- Sangwatanaroj S, Prechawat S, Sunsaneewitayakul B, Sitthisook S, Tosukhowong P, Tungsanga K. New electrocardiographic leads and the procainamide test for the detection of the Brugada sign in sudden unexplained death syndrome survivors and their relatives. Eur Heart J. 2001 Dec;22(24):2290-6.
- Wilde AA, Antzelevitch C, Borggrefe M, Brugada J, Brugada R, Brugada P, Corrado D, Hauer RN, Kass RS, Nademanee K, Priori SG, Towbin JA; Study Group on the Molecular Basis of Arrhythmias of the European Society of Cardiology. Proposed diagnostic criteria for the Brugada syndrome: consensus report. Circulation. 2002 Nov 5;106(19):2514-9. Review.
- ECG Brugada patterns