Computer-based Training of Face Recollection to Improve Face Recognition in Developmental Prosopagnosia
Sponsor
Harvard Medical School (HMS and HSDM) (Other)
Overall Status
Recruiting
CT.gov ID
NCT04799340
Collaborator
(none)
60
1
3
15.6
3.8
Study Details
Study Description
Brief Summary
This study will examine the effectiveness of a cognitive training intervention targeting face recollection, repetition lag training, at improving face recognition in Developmental Prosopagnosia.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Study Type:
Interventional
Anticipated Enrollment
:
60 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Double (Participant, Outcomes Assessor)
Primary Purpose:
Treatment
Official Title:
Characterizing and Remediating Recollection-specific Face Recognition Deficits in Developmental Prosopagnosia
Actual Study Start Date
:
Mar 12, 2021
Anticipated Primary Completion Date
:
May 31, 2022
Anticipated Study Completion Date
:
Jul 1, 2022
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: holistic face training
|
Behavioral: cognitive training
training to improve encoding and recognition of faces
|
| Experimental: holistic face training + repetition lag training
|
Behavioral: cognitive training
training to improve encoding and recognition of faces
|
| No Intervention: waitlist control
|
Outcome Measures
Primary Outcome Measures
- Cambridge Face Memory Test [15 minutes]
learning and recognizing novel faces
- Face Recollection [15 minutes]
old/new face recognition test, extracting familiarity and recollection parameters
- Face Perception [30 minutes]
composite of face matching tasks
Secondary Outcome Measures
- Self-reported face recognition [5 minutes]
questionnaire
- Face-name learning task [15 minutes]
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
to 65 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
- Developmental prosopagnosic participants will be included if they are aged 18-65, have lifelong histories of face recognition difficulties that impact their everyday life (i.e., not associated with some event such as a stroke, seizure, etc), and score > 2 standard deviations below the mean on the famous faces test and Cambridge Face Memory Test. This is in line with our previous studies and others in the literature.
Exclusion Criteria:
- Participants will be excluded from the study if they have a developmental social cognitive disorder such as autism or history of a significant neurological disorder including hydrocephalus, stroke, moderate to severe traumatic brain injury (TBI), severe neuromuscular diseases, or severe hypoxia due to cardiac arrest. Patients with a history of mild TBI or simple concussion will not be excluded as long as it was > 6 months ago and as long as they have not had repeated concussions (>5). Participants will be excluded if they have impairments that interfere with cognitive performance, such as uncorrected hearing or vision, lack of English proficiency, musculoskeletal or other issues. Additionally, participants will be excluded if they have psychiatric disorders, such as schizophrenia, major depressive disorder, bipolar disorder, chronic intractable obsessive-compulsive disorder, or agoraphobia. We will include individuals with a diagnosis of ADHD as long as their medication has been consistent for the past 6 months. We will exclude individuals who are currently dependent on alcohol or other substances, as this may negatively impact cognitive performance. We will exclude participants who currently are, or within the last 6 months, participating in a behavioral or pharmacological intervention.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | VA Boston Healthcare System, 150 S. Huntington Ave. | Boston | Massachusetts | United States | 02130 |
Sponsors and Collaborators
- Harvard Medical School (HMS and HSDM)
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Joseph DeGutis,
Assistant Professor,
Harvard Medical School (HMS and HSDM)
ClinicalTrials.gov Identifier:
NCT04799340
Other Study ID Numbers:
- R21EY031000
First Posted:
Mar 16, 2021
Last Update Posted:
Mar 16, 2021
Last Verified:
Mar 1, 2021
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms: