Efficacy of Dexmedetomidine as an Adjuvant to Quadratus Lumborum Block
Study Details
Study Description
Brief Summary
This prospective double blinded study will be conducted over 60 pediatric patients ASA (American Association of Anesthesiologists) I and II between the age of 1-7 years old, who will be scheduled for unilateral groin surgery. Patients will be randomly allocated into 3 study groups: Control group that only received local anesthetics ( bupivacaine) Group II bupivacaine with the dexmetedomidine ( 0,5mcg/kg ) and group III bupivacaine with the dexmedetomidine (1mcg/kg).Patients in all groups will receive quadratus lumborum block.
Bradycardia, hypotension, atropine, and bolus fluid infusion requirements will be recorded. When there was up to a 30% decrease in basal mean blood pressure, a crystalloid infusion bolus will be given at 10 ml/kg. When bradycardia occurred , atropine will be given at a dose of 0.02 mg/kg. Patients will be followed up in the postoperative recovery unit for the first 2 hours, and then in the ward. The RAMSEY sedation scale and WATCHA agitation scale were evaluated at 5, 15, 30, and 60 minutes in the postoperative recovery unit. Nausea, vomiting, and other side effects were recorded if present.
Time to first analgesic requirement ( primary outcome) , FLACC Scale scores will be recorded within 24h postoperatively, total dose of analgesic consumption, incidence of postoperative complications as hypotension, bradycardia, vomiting, pruritis and respiratory depression will be recorded.
Condition or Disease | Intervention/Treatment | Phase |
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Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Group I (Control group) group I: quadratus lumborum block with 0,25% bupivacaine 0,5 ml/kg |
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Group II groupII: quadratus lumborum block with 0,25%bupivacaine 0,5 ml/kg and dexmedetomidine 0,5 mcg/kg as an adjuvant |
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Group III groupIII: quadratus lumborum block with 0,25% bupivacaine 0,5 ml/kg and dexmedetomidine 1 mcg/kg as an adjuvant |
Outcome Measures
Primary Outcome Measures
- the time to first rescue analgesic requirement [24 hours]
the time to first rescue analgesic requirement within the first 24 postoperative hours,
Secondary Outcome Measures
- postoperative pain scores FLACC [24 hours]
postoperative pain assessment score in children
- additional analgesic consumption [24 hours]
total analgesic consuption within 24 hours
- postoperative sedation scores RAMSEY [1 hour]
patient's sedation scores within postoperative first one hour
- incidence of complications [24 hours]
Incidence of intraoperative and postoperative complications or side effects
Eligibility Criteria
Criteria
Inclusion Criteria:
The study included children aged 1-7 years with ASA (American Society of Anesthesiologists) I-II, who underwent elective, unilateral, groin surgery (inguinal hernia, orchiopexy, hydrocele) with the consent of their families
Exclusion Criteria:
- Children who were aged outside the range of 1-7 years, with ASA III or higher, allergic to local anesthetics, had an infection in the injection area, had contraindications for regional anesthesia such as coagulopathy, whose families did not give consent, were undergoing laparoscopic orchidopexy, undergoing bilateral surgery, had a body mass index of >30 kg/m2, and were expected to be admitted to the intensive care unit during the postoperative period were excluded from the study
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | PINAR Kendigelen | Istanbul | Please Select | Turkey | 34098 |
Sponsors and Collaborators
- Istanbul University - Cerrahpasa (IUC)
Investigators
- Study Director: PINAR Kendigelen, Prof., Istanbul University - Cerrahpasa (IUC)
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- E-83045809-604.01.01-631721