Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency
Sponsor
National Center for Research Resources (NCRR) (NIH)
Overall Status
Completed
CT.gov ID
NCT00011141
Collaborator
(none)
1
Study Details
Study Description
Brief Summary
The etiology of immune-mediated diabetes mellitus (IMD) remains unclear. However, previous studies indicate that autoimmunity may be a result of dysfunction of natural killer T cells (NK-T cells). Newly diagnoses patients with IMD have been shown in our laboratory to have significantly lower NK-T cells than normal controls. Other studies have shown that oral administration of lactobacillus can boost NK-T cell activity in children with HIV without side effects. Our objective is to evaluate the effect of lactobacillus administration on NK-T cell activity in patients with IMD
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Study Type:
Interventional
Allocation:
Randomized
Intervention Model:
Single Group Assignment
Masking:
Double
Primary Purpose:
Treatment
Official Title:
Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
Ages Eligible for Study:
1 Year
to 95 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Recently diagnosed (within the last 6 months) patients with immune-mediated (type 1) diabetes
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Cornell University | New York | New York | United States | 10021 |
Sponsors and Collaborators
- National Center for Research Resources (NCRR)
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
,
,
ClinicalTrials.gov Identifier:
NCT00011141
Other Study ID Numbers:
- NCRR-M01RR06020-0165
First Posted:
Feb 14, 2001
Last Update Posted:
Jun 24, 2005
Last Verified:
Dec 1, 2003
Keywords provided by ,
,
Additional relevant MeSH terms: