Multicenter Clinical Study of Anti-VEGF Treatment on High Risk Diabetic Retinopathy (DR)

• Sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT03452657
• Collaborator: RenJi Hospital (Other), Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (Other), Eye & ENT Hospital of Fudan University (Other), Shanghai Jiao Tong University Affiliated Sixth People's Hospital (Other), Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University (Other), Shanghai 10th People's Hospital (Other), Shanghai Tongji Hospital, Tongji University School of Medicine (Other)
• Enrollment: 118
• Locations: 7
• Arms: 2
• Anticipated Duration (Months): 26
• Patients Per Site: 16.9
• Patients Per Site Per Month: 0.6

Study Details

Study Description

Brief Summary

The purpose of this study is to determine the efficacy and safety of intravitreous ranibizumab treatment versus sham injections for prevention of high-risk DR.

Condition or Disease	Intervention/Treatment	Phase
Diabetic Retinopathy; Ranibizumab	Drug: Ranibizumab; Procedure: No drug	Phase 3

Detailed Description

This study is a randomized, double-blind, multi-center, sham-controlled clinical trial. In this trial, 118 subjects will be enrolled. Subjects with signed informed consent are screened and assigned randomly (1:1) to one of the following parallel groups: Group A-Intravitreous 0.5 mg ranibizumab injections and Group B-sham injections. All participants have visits at 0 month, 1 month, and 2 months, followed by visits every 3 months thereafter through 1 year. The main efficacy and safety outcomes assessment will be finished at the end of 12 months.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 118 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
• Primary Purpose: Treatment
• Official Title: Multicenter Clinical Study of Anti-VEGF Treatment on High Risk Diabetic Retinopathy (DR)
• Anticipated Study Start Date: Apr 1, 2018
• Anticipated Primary Completion Date: Jun 1, 2019
• Anticipated Study Completion Date: Jun 1, 2020

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Ranibizumab Participants received 0.5mg intravitreal ranibizumab injection	Drug: Ranibizumab; Participants in arm Ranibizumab will receive ranibizumab injection every 4 weeks for the first 3 months, followed by re-injections every 3 months until 1year; Other Names: Lucentis
Sham Comparator: Sham-injection No drug involved in the sham procedure; patient's eye is anesthetized and a syringe without needle gently pressed on the conjunctival surface to simulate the force of an actual injection	Procedure: No drug; Participants in arm Sham-injection will receive sham injection every 4 weeks for the first 3 months, followed by re-injections every 3 months until 1year.

Outcome Measures

Primary Outcome Measures

1. Proportion of eyes with a ≥ 2-step improvement in the ETDRS Diabetic Retinopathy Severity Scale (DRSS) score [1 year]

   Baseline ETDRS DRSS: None (level 10); Mild to moderate nonproliferative DR (levels 14, 15, 20, 35, and 43); Moderately severe/severe nonproliferative DR (levels 47 and 53); Mild/moderate/high-risk/advanced proliferative DR (levels 61, 65, 71,75, 81, and 85)

Secondary Outcome Measures

1. Change from baseline in CRT (central retinal thickness) [1 year]

   Assessed on Optical Coherence Tomography (OCT)

2. Mean change from baseline in best-corrected visual acuity (BCVA) [1 year]

   Visual function of the study eye was assessed using the ETDRS protocol.

3. Proportion of eyes that meet the protocol-defined failure criteria [1 year]

   Failure criteria: Evidence of progression to PDR: Retinal neovascularization Iris neovascularization PDR related clinical manifestations: vitreous hemorrhage, tractive retinal detachment, etc.. Patients who meet failure criteria will receive salvage therapy: PRP treatment.

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 100 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

1. Age >= 18 years;

2. Diagnosis of diabetes mellitus (type 1 or type 2);

3. The fundus color photography was graded by Reading Center as grade 47-53;

4. Patients have not received Pan Retinal Photocoagulation (PRP: laser spots on fundus outside hemal arch are less than 100);

5. HbA1C≤ 10%;

6. Media clarity and pupillary dilation sufficient to obtain adequate fundus examinations;

7. No central subfield macular edema.

Exclusion Criteria:

1. Ocular infection, including conjunctivitis, chalazion, or substantial blepharitis;

2. Proliferative diabetic retinopathy;

3. History of prior vitreous hemorrhage within 2 months;

4. An ocular condition is presented (other than DR), (e.g., retinal vein or artery occlusion, CNV, retinal detachment, macular hole, vitreomacular traction, etc.);

5. Evidence of iris neovascularization;

6. Evidence of uncontrolled glaucoma( Intraocular pressure >25 mmHg with glaucoma medication) or history of anti-glaucoma surgery;

7. Server cataract that influences judgment or needs cataract surgery in 6 months;

8. Aphakia;

Received other ocular treatment:

1. History of intravitreal injection of corticosteroid within 3 months, or peribulbar injection of corticosteroid within 1 month;

2. History of vitreous surgery;

3. History of PRP ≥ 2 times or within 6 months in the study eye;

4. History of focal laser treatment within 3 months or laser treatment involving fovea ≥ 2 times in the past in the study eye;

5. History of anti-VEGF treatment within 6 months in the study eye or history of anti-VEGF treatment within 3 months in the non-study eye;

6. History of any intraocular surgery within 3 months;

7. History of macular surgery within 3 months;

Have any following condition of systemic diseases:

1. Unsatisfactory blood glucose control within 3 months (defined as turn oral antidiabetic drugs into insulin therapy/insulin pump treatment or daily insulin injection times doubled);

2. Impaired renal function (Crea: 2 times higher than the upper limit of the normal laboratory center) or liver dysfunction (ALT, AST: 2 times higher than the upper limit of the normal laboratory center );

3. Poor blood pressure control (defined as systolic blood pressure ≥ 150 mmHg or diastolic blood pressure ≥ 95 mmHg under antihypertensive therapy);

4. Any systemic infection that requires oral, intramuscular or intravenous administration ;

5. Stroke, transient ischemic attack, myocardial infarction or acute congestive heart failure occurred within 6 months before the screening;

6. Coagulation dysfunction (prothrombin time ≥ normal upper limit of 3 seconds, activated partial thromboplastin time ≥ normal upper limit of 10 seconds);

7. Drugs that are toxic to the lens, retina, or optic nerve are being used or may be required during the study (such as deferoxamine, chloroquine, hydroxychloroquine, tamoxifen, phenothiazine or ethambutol, etc.);

8. Have a diagnosis of systemic immune diseases (such as ankylosing spondylitis, systemic lupus erythematosus, etc.) or any uncontrollable clinical problems (such as AIDS, malignancy, active hepatitis, severe mental, neurological, cardiovascular, Respiratory and other diseases, etc.);

9. Known allergy to fluorescein dye, or protein products for treatment or diagnosis, or allergies to more than two drugs and / or nonpharmacological factors, or is suffering from allergic diseases;

Other:

1. No use of effective contraception; Note: The following conditions are not excluded. I. Amenorrhea 12 months under natural circumstances, or natural amenorrhea for 6 months and serum follicle-stimulating hormone levels <40 mIU / ml; Ii. Bilateral ovariectomy with or without hysterectomy after 6 weeks; Iii. Use of one or more of the following acceptable contraceptive methods: sterilization (male with bilateral vasectomy, resection) , hormone contraceptive (implantable, patch-type, oral) , O IUD, or double barrier method; Iv. Reliable contraceptive measures used throughout the whole study period and adherence to the 30 days of discontinuation of the study drug (unacceptable contraceptive methods: regular abstinence - calendar, ovulation, body temperature, post-ovulation, Row fine);

2. Pregnant (pregnancy in this test is defined as urine pregnancy test positive) or lactating women;

3. Within 3 months (if the test drug has a long half-life and five half-life periods > 3 months, the time is 5 half-life periods) before screening, participated clinical trials of any drug (not including vitamins and minerals);

4. Those that researchers believe need to be excluded.

Exit Criteria:

During the clinical trial, patients may withdraw from the trial at any time for their own consideration or at the request of the investigator. For each subject who withdrawn from the trial, the investigator must detail the exit date, reasons, and other information in the case report form and original documents.

Subjects must withdraw from the study if:

1. Withdrawal of informed consent;

2. Participating in other clinical trials of new drugs during the trial;

3. Pregnancy during the trial;

4. Occurrence of ocular serious adverse events;

5. For safety, the researcher consider that the subject should withdraw from the trial.

Subjects may withdraw from the study early because of the following conditions:

1. Lost to follow-up;

2. Compliance issues;

3. Delay of injection more than 30 days for any reason;

4. Retinal laser photocoagulation is required during the trial;

5. Researchers consider that the treatments in this study (including remedial treatment) are no longer suitable for DME therapy in subjects;

6. Occurrence of adverse events or serious adverse events (subjects that need hospitalization or prolongation of hospital stay due to adverse events, without affecting the safety and efficacy evaluation, may not exit);

7. Use of prohibited drugs during the study;

8. Deviation from the research protocol.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Eye and ENT hospital of Fudan University	Shanghai		China
2	Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine	Shanghai		China
3	Shanghai ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine	Shanghai		China
4	Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University	Shanghai		China
5	Shanghai Tenth People's Hospital of Tongji University	Shanghai		China
6	Shanghai Tongji Hospital of Tongji University	Shanghai		China
7	Xinhua Hospital Afflilliated to Shanghai Jiaotong University School of Medicine	Shanghai		China

Sponsors and Collaborators

• Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
• RenJi Hospital
• Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
• Eye & ENT Hospital of Fudan University
• Shanghai Jiao Tong University Affiliated Sixth People's Hospital
• Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
• Shanghai 10th People's Hospital
• Shanghai Tongji Hospital, Tongji University School of Medicine

Investigators

• Study Chair: Xun Xu, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Xun Xu, Chief Physician, Professor, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
• ClinicalTrials.gov Identifier: NCT03452657
• Other Study ID Numbers: DLY201612
• First Posted: Mar 2, 2018
• Last Update Posted: Mar 2, 2018
• Last Verified: Mar 1, 2018

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Product Manufactured in and Exported from the U.S.: Yes
• Additional relevant MeSH terms: Retinal Diseases; Diabetic Retinopathy; Ranibizumab

Study Results

No Results Posted as of Mar 2, 2018